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Novartis

Medicine/Pharmacology - Chemistry
16.12.2014
Novartis gains FDA approval for Signifor LAR to treat patients with acromegaly, a rare and life-threatening hormonal disorder
Novartis Global select country select business Acromegaly is an endocrine disorder caused by elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels
Medicine/Pharmacology - Life Sciences
12.12.2014
Novartis announces results of trial evaluating the use of Afinitor in first-line treatment in HER2+ advanced breast cancer at SABCS
Novartis Global select country select business BOLERO-1 trial explored everolimus in women with HER2+ advanced breast cancer and did not meet criteria for statistical significance
Medicine/Pharmacology - Life Sciences
12.12.2014
Head-to-head psoriasis study demonstrates superiority of Novartis Cosentyx(TM) to Stelara in clearing skin
Novartis Global select country select business Cosentyx showed superiority to Stelara ; meeting the primary endpoint of achieving PASI 90, which represents clear or almost clear skin at Week 16 and secondary endpoint of achieving PASI 75 at Week 4 for psoriasis patients CLEAR is the second head-to-head study for Cosentyx following the Phase III FIXTURE study that showed Cosentyx was superior to Enbrel (etanercept)
Medicine/Pharmacology - Chemistry
08.12.2014
Six-year pivotal study data reinforce the superiority of Tasigna over Glivec in newly-diagnosed patients with Ph+ CML
Fewer patients on Tasigna vs.
Medicine/Pharmacology - Social Sciences
08.12.2014
Novartis announces safety and efficacy benefit of Jakavi in global clinical trial of over 1,000 patients with myelofibrosis
Data from ongoing trial reinforces the safety profile of Jakavi (ruxolitinib) as seen in previous Phase III studies Patients on Jakavi experienced a reduction in spleen size that was mainta
Medicine/Pharmacology - Physics/Materials Science
08.12.2014
Phase III data shows Sandoz’ investigational biosimilar filgrastim has similar safety and efficacy as Amgen’s NEUPOGEN
Pivotal PIONEER study compared safety and efficacy of the two compounds in the prevention of neutropenia in patients with breast cancer PIONEER data supported filing for biosimilar filgrastim in the US The abstract of the study results is published online as part of the 56th American Society of Hematology (ASH) Annual Meeting and Exposition Holzkirchen, December 8, 2014 - Sandoz, a Novartis company, announced today Phase I
Medicine/Pharmacology - Life Sciences
06.12.2014
Novartis highlights new CTL019 clinical data showing complete remissions in children and young adults with relapsed/refractory acute lymphoblastic leukemia
Data shows 36 of 39 pediatric patients with relapsed/refractory acute lymphoblastic leukemia (r/r ALL) (92%) experienced complete remissions Additionally, sustained remissions were achieved up to one year or more with 6-month event-free survival of 70% and overall survival of 75%, in most cases without further therapy Novartis and Penn have exclusive global collaboration to research, develop and commercialize CAR'T cell therapie
Medicine/Pharmacology - Life Sciences
02.12.2014
Novartis features innovative immunotherapy, targeted pipeline treatment combinations and long-term data at ASH and SABCS 2014
Update on complete remissions with personalized cell therapy CTL019 in patients with relapsed/refractory acute lymphoblastic leukemia Studies targeting multiple cancer pathways in rare blood ca
Medicine/Pharmacology - Life Sciences
01.12.2014
Novartis provides update on fingolimod Phase III trial in primary progressive MS (PPMS)
PPMS is distinct from other types of MS, with no approved treatment that can change the course of this devastating disease Novartis remains strongly committed to identifying and developing treatment options for patients with chronic debilitating neurological conditions Basel, Dec 1, 2014 - Novartis announced today that the Phase III INFORMS study in primary progressive multiple sclerosis (PPMS) did not show a significant difference between fingolimod and placebo on a combination of disability measures.
Medicine/Pharmacology
28.11.2014
Novartis’ heart failure medicine LCZ696 granted accelerated assessment by CHMP in Europe[1]
LCZ696 is the first investigational cardiovascular drug to be granted accelerated assessment, shortening the formal review clock by 60 days Approximately 15 million people in the EU live with
Medicine/Pharmacology
25.11.2014
Novartis announces extension to FDA review period for multiple myeloma investigational compound LBH589
Basel , November 25, 2014 - Novartis announced today that the US Food and Drug Administration (FDA) has extended their priority review period by up to three months for the new drug application (ND
Medicine/Pharmacology
24.11.2014
Novartis drug Signifor approved in EU, marking an advance for patients with inadequately controlled acromegaly
Acromegaly is a rare pituitary disorder, which requires normalization of hormonal levels to help prevent the serious consequences of the disease , , , Approval based on two large phase III
Medicine/Pharmacology - Life Sciences
21.11.2014
Novartis Cosentyx(TM) receives positive CHMP opinion for first-line treatment of moderate-to-severe psoriasis patients
Cosentyx (secukinumab, formerly AIN457) is recommended as first-line systemic therapy for the treatment of moderate-to-severe plaque psoriasis in adult patients in Europe In Phase III stud
Medicine/Pharmacology - Environmental Sciences
21.11.2014
Novartis Foundation symposium showcases sustainable healthcare interventions
Event illustrates how strong partnerships and innovative service delivery models can result in improved patient outcomes in lowand middle-income countries Selected interventions demonstrate success in moving past the pilot phase towards validation and scale, including a telemedicine project that aims to improve healthcare access in rural areas of Ghana The Novartis Foundation strategic approach to philanthropy includes partnerships,
Medicine/Pharmacology
17.11.2014
Nine new analyses show Novartis’ LCZ696 could change course of heart failure for patients[1],[2]
New data from PARADIGM-HF shows LCZ696 cut incidence of sudden deaths, emergency room visits, hospitalizations, worsening symptoms and need for more intense treatment in HFrEF patients versus enalapril Patients' and doctors' assessments of disease severity were also significantly better with LCZ696 than enalapril Effects on certain heart biomarkers indicate that compared to enalapril, LCZ696 reduced cardiac stress and damage
Medicine/Pharmacology
16.11.2014
Novartis reports landmark Phase III results for AIN457 (secukinumab) showing rapid and significant efficacy in psoriatic arthritis patients
Secukinumab demonstrated significant and sustained efficacy versus placebo in improving signs and symptoms of active psoriatic arthritis (PsA) in two pivotal studies - FUTURE 1 and FUTURE 2 are the first Phase III studies of a selective IL-17A inhibitor in PsA, a painful, debilitating condition causing inflammation of joints and skin , In FUTURE 1 more than 80% of secukinumab-treated patients experienced no progression of joi
Medicine/Pharmacology - Life Sciences
15.11.2014
Novartis presents ground-breaking Phase III results showing AIN457 (secukinumab) significant efficacy in ankylosing spondylitis patients
More than 60% of secukinumab 150 mg patients achieved significant improvements in AS symptoms, seen as early as Week 1 and sustained through one year of treatment , Secukinumab is the first selective IL-17A inhibitor to significantly improve signs and symptoms of ankylosing spondylitis (AS) versus placebo in Phase III studies , Up to 40% of AS patients have inadequate or no response to standard of care anti-TNF (tumor-necrosis-facto
Medicine/Pharmacology - Business/Economics
12.11.2014
Novartis and Malaria No More help fulfill malaria treatment goal in Zambia by raising funds for three million treatments through Power of One
Power of One campaign, supported by exclusive treatment sponsor Novartis, raises funds for three million treatments for children with malaria Novartis associates rallied behind Power of One
Medicine/Pharmacology - Physics/Materials Science
10.11.2014
Novartis to reveal landmark Phase III data for AIN457 (secukinumab) in psoriatic arthritis and ankylosing spondylitis at ACR 2014
Detailed results of four pivotal Phase III studies of secukinumab in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) to be presented for the first time at ACR 2014 Secukinumab is the first selective interleukin-17A (IL-17A) inhibitor with Phase III data to demonstrate efficacy and improve symptoms in patients with PsA and AS Data will include study results from FUTURE 1 and FUTURE 2 in PsA and MEASURE 1 and MEASURE 2 in AS;
Medicine/Pharmacology
06.11.2014
Novartis announces outcome of FDA advisory committee meeting for multiple myeloma investigational compound LBH589
Committee votes against recommending LBH589 plus bortezomib and dexamethasone for patients with previously treated multiple myeloma LBH589 has the potential to be an important treatment optio
Business/Economics - Medicine/Pharmacology
28.10.2014
Novartis delivered solid sales growth with strong margin expansion and major innovation in the third quarter
Net sales up 4% (+5% cc) in Q3, with operating margin increase across Q3 and 9M Net sales of USD 14.7 billion grew 4% (+5% cc ) in Q3 Strong operating income growth in Q3 of 14% (+18% cc) Core
Medicine/Pharmacology - Business/Economics
26.10.2014
Novartis announces divestiture of influenza vaccines business to CSL for USD 275 million
CSL to acquire Novartis influenza vaccines business, including development pipeline, for USD 275 million Announcement follows a transaction announced on April 22, 2014 to divest the non-influen
Medicine/Pharmacology - Life Sciences
23.10.2014
Novartis AIN457 (secukinumab) meets primary endpoint in two Phase III studies in ankylosing spondylitis, a debilitating joint condition of the spine
Secukinumab is the first selective IL-17A inhibitor to meet primary endpoint in two pivotal Phase III studies showing improvement in active ankylosing spondylitis (AS) patients' symptoms versus placebo AS is a painful, progressively debilitating condition associated with inflammation of the spine, causing irreversible consequences that significantly reduce patients' mobility and quality of life , Up to 40% of patients have an
Medicine/Pharmacology - Life Sciences
20.10.2014
Novartis announces FDA Advisory Committee unanimously recommends approval of AIN457 (secukinumab) for patients with moderate-to-severe plaque psoriasis
Biologics License Application (BLA) for secukinumab, a "first-in-class" IL-17A inhibitor, is currently under FDA review with an anticipated action date in early 2015 FDA Advisory Committee recommendation based on efficacy and safety outcomes of 10 Phase II/III clinical studies of secukinumab in moderate-to-severe plaque psoriasis Affecting 7.5 million Americans, psoriasis may negatively impact daily life and is associated with increas
Medicine/Pharmacology - Life Sciences
15.10.2014
Novartis announces CTL019 data published in NEJM demonstrating efficacy in certain patients with acute lymphoblastic leukemia (ALL)
Preliminary study results show 27 of 30 pediatric and adult patients with relapsed/refractory (r/r) ALL (90%) experienced complete remissions with personalized cell therapy, CTL019 Largest published cohort to date for CTL019, which served as the basis for recent Breakthrough Therapy designation from the FDA Sustained remissions of up to two years in r/r ALL patients with six-month event-free survival of 67% and overall survival of 7
Medicine/Pharmacology
10.10.2014
Novartis data at EADV show consistent efficacy of AIN457 (secukinumab) in clearing skin of psoriasis patients
New analyses of Phase III data show consistent efficacy in clearing psoriasis skin with AIN457 (secukinumab) regardless of how bad patients' disease is at start of treatment Significant positive responses to secukinumab seen in patients with severe psoriasis at start of treatment Significant positive relationship between achieving clear to almost clear skin and psoriasis patients' health-related quality of life, as shown by add
Medicine/Pharmacology - Business/Economics
09.10.2014
New data on the global economic impact and burden of preventable blindness and vision impairment highlighted for World Sight Day
Annual economic impact equals more than 350,000 healthy life years lost and over €20 billion EUR as a result of blindness for 14 countries studied Screening for diabetic retinopathy, catarac
Medicine/Pharmacology - Business/Economics
08.10.2014
Changes to the Novartis Executive Committee after expected completion of portfolio transactions
Three members of the Executive Committee of Novartis to leave company, following completion of portfolio transactions expected to close in first half 2015 Basel, October 8, 2014 - Novartis
Medicine/Pharmacology
06.10.2014
Novartis announces clinical collaboration to evaluate Bristol-Myers Squibb’s novel immunotherapy in combination treatments for NSCLC
Phase I/II studies will evaluate Zykadia(TM), INC280 and EGF816 in combination with Bristol-Myers Squibb's investigational immunotherapy Opdivo Combination studies will evaluate compounds
Medicine/Pharmacology - Life Sciences
01.10.2014
Novartis showcases dermatology leadership on International Urticaria Day announcing new data to be presented at EADV 2014
New data for the IL-17A inhibitor AIN457 (secukinumab) in psoriasis and Xolair in Chronic Spontaneous Urticaria (CSU) at EADV to highlight benefit to patients' quality of life Data continue to reinforce the landmark Phase III results of secukinumab in psoriasis and Xolair in CSU that showed consistent, fast efficacy and acceptable safety - Important head-to-head trial of secukinumab versus Stelara (CLEAR), powered to eval
Medicine/Pharmacology - Life Sciences
27.09.2014
Patients lived average of 18 months without cancer progressing when taking Novartis’ Zykadia(TM) as their first ALK inhibitor for ALK+ NSCLC
Longest median progression-free survival (PFS) ever reported in this ALK+ non-small cell lung cancer patient population, most who received prior chemotherapy Zykadia (ceritinib) achieved ov
Medicine/Pharmacology - Life Sciences
27.09.2014
Novartis drug Afinitor is first treatment for advanced pancreatic NET to provide overall survival of more than 3.5 years in Phase III trial
Afinitor led to an unprecedented median overall survival of 44 months, which represents a clinically meaningful while not statistically significant improvement Pancreatic NET (pNET) affects ab
Medicine/Pharmacology
26.09.2014
Novartis drug Signifor LAR recommended by CHMP for EU approval to treat patients with rare hormonal disorder acromegaly
Acromegaly is an endocrine disorder caused by elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels Signifor LAR (pasireotide) represents a potential new option for acro
Medicine/Pharmacology
25.09.2014
Novartis AIN457 (secukinumab) is the first ever IL-17A inhibitor to meet primary endpoint in two Phase III studies in psoriatic arthritis
Secukinumab met primary and key secondary endpoints in two pivotal Phase III studies showing superiority to placebo in patients with adult onset psoriatic arthritis (PsA) PsA is a debilitating, long-lasting condition that causes inflammation of joints and skin and affects up to 30% of people with psoriasis globally , Many people with PsA do not respond to current standard of care, with approximately 45% of people dissatisf
Medicine/Pharmacology
19.09.2014
Novartis data in The Lancet Oncology show LBH589 offers 4-month increase in median PFS for patients with multiple myeloma
Results show statistically significant and clinically relevant increase in median progression-free survival with LBH589 plus bortezomib and dexamethasone LBH589, a first-in-class treatment for patients with relapsed/refractory multiple myeloma if approved, helps extend benefit of standard-of-care therapy First Phase III study to demonstrate superiority of a three-drug over two-drug combination in this patient population Multip
Medicine/Pharmacology - Life Sciences
17.09.2014
Novartis presents oncology research advances with new data on Zykadia(TM), Afinitor and key pipeline compounds at ESMO 2014
Latest Zykadia data in patients with ALK+ non-small cell lung cancer, including updated brain metastases analysis from pivotal trial Final overall survival data from Phase III trial of Afini
Medicine/Pharmacology - Business/Economics
13.09.2014
Novartis demonstrates leadership in ophthalmology with new products and over 40 abstracts at EURETINA
Retrospective analysis of US claims data suggests risk of endophthalmitis is 65% higher in patients treated with aflibercept than those treated with Lucentis Presentations discuss safety o
Medicine/Pharmacology - Life Sciences
12.09.2014
New data confirm high efficacy of Gilenya
A key treatment goal for patients with MS is 'no evidence of disease activity' (NEDA), currently defined as no relapses, MRI lesions and disability progression Including MS-related brain shrinkage (brain volume loss) as a fourth key measure captures underlying damage that begins early in MS and is associated with loss of function The likelihood of achieving NEDA across four key measures was more than four-times greater in patients treat
Medicine/Pharmacology - Event
11.09.2014
Novartis announces eXcellence in Ophthalmology Vision Award 2014 winners for outstanding eye health projects
Life Sciences - Medicine/Pharmacology
10.09.2014
Gilenya data confirm reducing brain shrinkage matters
Brain shrinkage is associated with a loss of physical and cognitive function and occurs at a faster rate in people with MS than those without the disease New data showed patients who had the highest rates of brain shrinkage (brain volume loss) at two years had a higher risk of disability progression at four years Separate analyses showed that patients continuously treated with Gilenya for six years had sustained low rates of brain shri
Medicine/Pharmacology
07.09.2014
Novartis data at ERS 2014 show once-daily Ultibro Breezhaler is superior in reducing COPD flare ups compared to Seretide *
Once-daily Ultibro Breezhaler reduced exacerbations (flare ups) by 31% compared to twice-daily Seretide Accuhaler * in moderate-to-severe COPD patients LANTERN study further confirmed superiority of Ultibro Breezhaler in improving lung function compared to Seretide in moderate-to-severe COPD patients First presentation of LANTERN trial at European Respiratory Society International Congress involving over 700 COPD
Medicine/Pharmacology - Life Sciences
03.09.2014
Gilenya data at ACTRIMS-ECTRIMS to show Novartis is redefining MS treatment goals for patients
'No evidence of disease activity' (NEDA), the ultimate treatment goal in MS, is currently assessed by measuring relapses, MRI lesions and disability progression New Gilenya data will highlight importance of brain shrinkage as NEDA fourth key measure, giving physicians more complete assessment of MS disease in patients Separate analyses will confirm the clinical relevance of brain shrinkage based on its association with future long-ter
Medicine/Pharmacology - Business/Economics
02.09.2014
Novartis to unveil new data from three key clinical trials at European Respiratory Society International Congress 2014
First presentation of LANTERN study to confirm superior efficacy of once-daily Ultibro Breezhaler versus Seretide Accuhaler * in COPD patients QUANTIFY study to show superiority of Ultibro Breezhaler in lung function and shortness of breath versus tiotropium plus formoterol New data from GLISTEN study will provide important evidence for the benefits of once-daily Seebri Breezhaler
Medicine/Pharmacology - Physics/Materials Science
30.08.2014
Novartis’ LCZ696 cut cardiovascular deaths by 20%
Study showed significantly more HF-REF patients on LCZ696 regimen were alive, had fewer hospitalizations than those given enalapril regimen On all-cause mortality, LCZ696 doubled the effect that enalapril, an ACE-inhibitor, previously showed vs placebo when added to current best treatment for HF-REF , 26 million people across US and Europe live with heart failure , facing high risk of death and poor quality of life , Basel, Augus
Medicine/Pharmacology - Life Sciences
25.08.2014
Novartis experts and future scientific leaders meet at International BioCamp 2014 to consider ’The Race Against Time’
Global experts present potential solutions to support healthy aging from Novartis businesses and R&D organization The 11th annual event brings 60 top university students from 25 countries and t
Medicine/Pharmacology - Business/Economics
20.08.2014
Novartis provides drug candidate compounds to TB Alliance
Exclusive worldwide license from Novartis includes a novel class of drugs that is active against drug sensitive and multi-resistant strains of tuberculosis Basel, August 20, 2014 - Novartis has signed an exclusive worldwide licensing agreement with the Global Alliance for TB Drug Development (TB Alliance) for compounds to fight tuberculosis (TB) that have been discovered at the Novartis Institutes for Tropical Diseases (NITD).
Medicine/Pharmacology
11.08.2014
Novartis to showcase heart failure leadership at ESC Congress 2014 with results on new first of its type medicine LCZ696
LCZ696 significantly reduced cardiovascular deaths in head to head study against enalapril, in addition to current best treatment, in patients with HF-REF PARADIGM-HF is the largest heart failure study ever conducted - stopped early in March 2014 due to compelling efficacy , LCZ696 recently granted FDA Fast Track status - rolling submission expected to be complete by end of year Basel, August 11, 2014 - New data reveali
Medicine/Pharmacology - Business/Economics
30.07.2014
KAE609 shows promise as next generation treatment for malaria
KAE609 is the first antimalarial drug candidate with a novel mechanism of action to achieve positive clinical proof-of-concept in over 20 years KAE609 was tested in adult patients with uncomplicated malaria and showed a median parasite clearance time of 12 hours, including in patients with resistant infections For more than a decade, Novartis has been a leader in the fight against malaria, setting the current gold standard for tre
Medicine/Pharmacology - Life Sciences
29.07.2014
Novartis vaccine Bexsero sees high uptake in first large-scale public vaccination program to help protect against devastating meningitis B
Program in Québec's Saguenay-Lac-Saint-Jean region is the first public campaign globally to offer Bexsero to all from 2 months to 20 years of age More than 45,000 infants, young children an
Medicine/Pharmacology - Administration/Government
28.07.2014
Alcon’s Simbrinza approved in the EU to treat patients living with glaucoma, a chronic sight-threatening eye disease
Simbrinza provides a convenient option to reduce treatment burden versus concomitant administration of single drugs Simbrinza is the only beta blocker-free formulation combining two approved th
Life Sciences - Medicine/Pharmacology
24.07.2014
FDA accepts Sandoz application for biosimilar filgrastim
Sandoz is the first company to announce it has filed for approval of a biologic under the biosimilars pathway created in the Biologics Price Competition and Innovation Act of 2009 (BPCIA).
Business/Economics - Medicine/Pharmacology
17.07.2014
Novartis maintained strong innovation momentum in second quarter, while reconfirming full year outlook
Net sales grew 2% in Q2, with core operating leverage across Q2 and H1 Net sales of USD 14.6 billion grew 2% (+2% cc ) in Q2; USD 28.7 billion (+2%, +2% cc) in H1 Strong operating income growth i
Medicine/Pharmacology
15.07.2014
Novartis to license Google "smart lens" technology
Innovative technology offers potential to transform eye care and further enhance Alcon's leadership in contact lenses and intraocular lenses Agreement is a first step for Novartis to evo
Medicine/Pharmacology - Life Sciences
15.07.2014
Novartis announces collaboration with Banner Alzheimer’s Institute on a pioneering prevention study for Alzheimer’s Disease
Two Novartis anti-amyloid investigational treatments will be studied in people with a genetic risk of developing Alzheimer's Disease (AD) The build-up of amyloid in the brain is believed to be
Medicine/Pharmacology - Life Sciences
09.07.2014
Novartis announces NEJM publication of two phase III studies demonstrating high efficacy of secukinumab (AIN457) in psoriasis patients
Results of two phase III psoriasis studies consistently show rapid, very high skin clearance, sustained efficacy and an acceptable safety profile with secukinumab More than 70% of secukinumab 300 mg patients experienced clear (PASI 100) or almost clear skin (PASI 90) during the first 16 weeks of treatment[ 1] If approved, secukinumab could address a high unmet need for new psoriasis treatments, as up to 50% of patients are dissat
Medicine/Pharmacology - Business/Economics
09.07.2014
Novartis releases 2013 Corporate Responsibility Performance Report using best-in-class reporting standard, increasing transparency
2013 Corporate Responsibility (CR) Performance Report builds on a long history of CR and reporting Report uses new Global Reporting Initiative G4 guidelines, one year ahead of required implem
Medicine/Pharmacology - Philosophy
08.07.2014
Novartis reinforces its leadership in research with new global guidelines for Investigator Initiated Trials (IITs)
Novartis committed to support ethical clinical research; new global guidelines emphasizing the principles of ethics, governance and transparency Clinical research conducted by qualified independent investigators is an important part of drug discovery and development and can help explore unmet medical needs New guidelines reinforce requirement that no commercial funding, involvement or influence are permitted in any aspect of IITs Basel, July 8, 2014 - Novartis released today new global guidelines for Investigator Initiated Trials (IITs).
Medicine/Pharmacology - Life Sciences
07.07.2014
Novartis personalized cell therapy CTL019 receives FDA Breakthrough Therapy designation
Designation supports the advancement of CTL019 to help address the unmet need of patients with relapsed/refractory acute lymphoblastic leukemia (r/r ALL) The filing was submitted by the Unive
Medicine/Pharmacology
30.06.2014
Sandoz joins forces with United Nations to combat a leading cause of child mortality worldwide
Sandoz makes long-term commitment to support UN initiative on child mortality Commitment to UN Every Newborn Action Plan involves development and supply of recommended WHO formulation for treat
 
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