Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research   link
Ort: Basel
Maulbeerstrasse 66, 4058 Basel

Kategorie: Gesundheit
Angliederung: Novartis

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Campus - 7.06
Campus
Starting a PhD can be daunting, especially during a pandemic, when uncertainty and social isolation can cause some extra emotional and logistical upheavals. That's why the FMI launched a 'mentor matching' initiative. By pairing senior PhD students with students who joined the institute during the COVID-19 pandemic, the initiative aims at helping newcomers meet their peers, navigate university bureaucracy, and familiarize themselves with Basel and the FMI.
Biowissenschaften - Psychologie - 26.05
Biowissenschaften - Psychologie

Fear protects us by making us alert to danger, but the persistence of fearful memories can lead to serious mental conditions. Now, an international team of researchers co-led by Andreas Lüthi has found that the activity of different cells in the brain's threat-detector hub regulates the switch between high and low fear states. The finding could help to understand why some individuals are more susceptible to anxiety and trauma-related disorders.

Biowissenschaften - Forschungsmanagement - 22.04

This year's recipients of the prestigious Advanced Grants from the European Research Council (ERC) have been announced today. The neurobiologist Prof. Silvia Arber, research group leader at the Friedrich Miescher Institute and the Biozentrum of the University of Basel, is among the awardees. Her funded project aims at understanding how brainstem neurons interact in the motor system to control generation and learning of body movements.

Biowissenschaften - Gesundheit - 13.04
Biowissenschaften - Gesundheit

The protection of genome integrity of germ cells is essential for animal fertility. Researchers from the Grosshans group characterized a defense mechanism against selfish genetic elements in the C. elegans germline. They identified a protein processing mechanism that controls the activity of small RNAs to achieve specific silencing of transposons while sparing endogenous genes.

Biowissenschaften - 17.03

Spotlight on FMIers is a new series that showcases the lives, work and passions of the institute's researchers and support staff. In the first interview of the series, Esther Griesbach, a postdoctoral fellow in the group of Jeffrey Chao, tells us about herself, the fascination with RNA and what she learned about embarking on a new research journey in COVID times.

Biowissenschaften - Chemie - 18.02
Biowissenschaften - Chemie

During development, scores of molecular signals prod cells to take on specialized identities and functions.

Biowissenschaften - Campus - 5.05

Spotlight on FMIers showcases the lives, work and passions of the institute's researchers and support staff. This time, graduate student Gergely Tihanyi tells us about his love for food and cooking, and he shares his insights on the FMI Master Chef series — virtual events where FMIers come together to cook and socialize.

Biowissenschaften - Chemie - 19.04
Biowissenschaften - Chemie

The spatial organization of the genome is fundamental for the regulation of our genes and has to be established de novo during early embryogenesis. By combining powerful Drosophila genetics with 3D chromosome modelling, a collaboration between the Giorgetti group at the FMI and the MPI of Immunobiology and Epigenetics in Freiburg revealed a critical role of the epigenetic regulator HP1 in the establishment of 3D genome organization in the early Drosophila embryo.

Biowissenschaften - Karriere - 6.04

April 6, 2021 We are pleased to announce the latest FMI winners of prestigious research fellowships, including EMBO, Maria Sklodowska-Curie Actions (MSCA), Human Frontier Science Program (HFSP) and Boehringer Ingelheim Funds (BIF).

Biowissenschaften - Psychologie - 3.03
Biowissenschaften - Psychologie

The brain's emotion-processing center — the amygdala — is one of several brain regions involved in social behavior.

Biowissenschaften - 16.02

In eukaryotes, histones are often modified and evicted at site of DNA double-strand breaks in order to facilitate end-resection and break repair. Together with the protein analysis facility of the FMI, the Gasser group has quantified massive changes in the chromatin associated proteome in response to DNA damage. Triggered by ubiquitin ligases, these changes drive the degradation of core and linker histones genome-wide, evict the transcription machinery and increase the efficiency of homologous recombination.




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