Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research   link
Location: Basel - North West Switzerland
Maulbeerstrasse 66, 4058 Basel

Discipline: Health
Affiliation: Novartis

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - May 15
Life Sciences
Over 200 high school students visited the FMI last week to learn more about biomedical research and the everyday life of a researcher. The goal of the event was to help the student better understand what it really means to work in research so that they can take more informed decisions about their course of study and professional future.
Health - Life Sciences - May 11
Health - Life Sciences

Researchers from FMI have identified a synthetic protein that dampens the activity of a cellular pathway involved in viral infection. The findings could help to develop drugs that combat viruses such as influenza A and Zika.

Life Sciences - Health - Apr 20

Cilia, the little "hairs" attached to almost all cells of the human body, play a role in various cellular functions and cause diseases called ciliopathies when they are defective. Researchers from the group of Patrick Matthias and the FMI Structural Biology platform determined the structure, at near atomic resolution, of a protein complex that plays an essential role in the assembly of cilia - and causes ciliopathies when it is mutated.

Computer Science - Mar 22
Computer Science

Researchers from the FMI Facility for Advanced Imaging and Microscopy (FAIM) are drivers of a large-scale international initiative dedicated to improving quality assessment and quality control in light microscopy. Recently, the workgroup chaired by the Head of FAIM delivered the first protocol for this initiative. It will help researchers from around the world improve the reliability, accuracy, and eventually reproducibility of their imaging experiments.

Life Sciences - Psychology - Feb 28
Life Sciences - Psychology

The emergence of autism traits can result from different factors, such as a person's environment and genetic background. FMI researchers and their Novartis collaborators showed that exposing mice with an autism mutation to a new environment can trigger autism-like behaviors — through faulty signaling in the brain. However, adding familiar objects to the environment can rescue these defects, suggesting that behavioral therapies involving familiar features may help to prevent the emergence of autism traits in predisposed people.

Health - Life Sciences - Feb 4

To discover the molecular mechanisms of health and disease, some FMI researchers use animals such as mice and fish. This animal research will help to understand the causes of conditions including cancer, Parkinson's disease and psychiatric disorders, paving the way to new diagnostic and therapeutic approaches. As head of the FMI animal facility, Gisèle Ferrand leads a large team of experts looking after the wellbeing of mice and fish used in experiments. In this Q&A, Gisèle talks about her career trajectory, how her team cares for lab animals, and what will happen if Swiss voters approve a referendum calling for a ban on animal experimentation.

Life Sciences - Health - Apr 26

Nicolas Thomä, a research group leader at the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel, receives the Otto Naegeli Prize for Medical Research, one of the most prestigious scientific awards in Switzerland.

Life Sciences - Mathematics - Apr 13
Life Sciences - Mathematics

When and where a gene is transcribed in a living organism often depends on its physical interactions with distal genomic regulatory regions called enhancers.

Life Sciences - Health - Mar 3
Life Sciences - Health

Silvia Arber from the FMI and the Biozentrum, University of Basel receives the Brain Prize 2022, the world's largest neuroscience Prize. With this award, the Lundbeck Foundation recognizes this year's three prize winners for their pioneering research into the neuronal circuits that control movement. The discovery of the fundamental cells and circuits underlying the regulation of vertebrate body movement is important in health and disease.

Pharmacology - Health - Feb 16
Pharmacology - Health

Cryo-electron microscopy, or cryo-EM for short, has revolutionized the way scientists image the smallest of structures. In a short video, the heads of the joint Novartis-FMI cryo-EM center discuss how the technique is advancing biomedical research and drug discovery, and where the field will go in the near future.

Life Sciences - Health - Jan 27

Three FMI postdoctoral researchers were among the recipients of the prestigious EMBO postdoctoral fellowships, autumn 2021 selection. In addition, an FMI student was recently awarded a Boehringer Ingelheim Fonds (BIF) fellowship. Read on to learn more about these researchers and their projects.




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