DNA is densely packed in the nucleus, forming occasional loops. These allow an enhancer to get in physical proximity of its target promoter.
DNA is densely packed in the nucleus, forming occasional loops. These allow an enhancer to get in physical proximity of its target promoter. When and where a gene is transcribed in a living organism often depends on its physical interactions with distal genomic regulatory regions called enhancers. Researchers in the group of Luca Giorgetti have thrown light on how such interactions control transcription thanks to a novel ingenious experimental approach combined with mathematical modelling. They found that gene expression levels depend on interaction frequencies with an enhancer. Their study establishes general principles for the role of chromosome structure in long-range transcriptional regulation. Transcription is the process by which the information contained in a section of DNA encoding a protein - a gene - is copied into messenger RNA (mRNA).
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