Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research   link
Lieu: Bâle
Maulbeerstrasse 66, 4058 Basel

Domaine: Santé
Affiliation: Novartis

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Santé - 16.08
Spotlight on FMIers showcases the lives, work and passions of the institute's researchers and support staff. This time, PhD candidate Marco Pregnolato tells us about his efforts to communicate science to the public and his dream of making a short film about climate change.
Sciences de la vie - Informatique - 2.08
Sciences de la vie - Informatique

Neuroscientists often use calcium imaging to analyze neuronal activity in the intact brain. But this method provides only an indirect and slow measure of action potential firing, creating the need to reliably reconstruct action potentials from calcium signals. Peter Rupprecht, a former PhD candidate in the Friedrich group, developed a novel algorithm based on machine learning that is very effective, easy to use, and highly robust. It has the potential to become a new standard for neurobiologists worldwide.

Sciences de la vie - Santé - 7.07
Sciences de la vie - Santé

Proteins known as transcription factors act as switches that regulate the expression of nearby genes, but the identity of some of these genetic levers has so far remained mysterious. Now, researchers from the Schübeler group have pinpointed a new switch that regulates essential genes in the mouse and the human genome. Identifying missing gene switches and their function is critical to fully understand the molecular basis of health and disease.

Sciences de la vie - 29.06
Sciences de la vie

How can proteins bind DNA in the cell nucleus, where it is present in form of chromatin, tightly wrapped around histones and therefore mostly inaccessible? Recently, several studies began to uncover the various strategies used by DNA-binding proteins to solve this problem. In a Cell "Leading Edge review", Alicia Michael and Nico Thomä look at these findings and highlight general principles that aim to help predict how a protein recognizes a specific stretch of DNA, even when "hidden" in chromatin.

Campus - 7.06

Starting a PhD can be daunting, especially during a pandemic, when uncertainty and social isolation can cause some extra emotional and logistical upheavals. That's why the FMI launched a 'mentor matching' initiative. By pairing senior PhD students with students who joined the institute during the COVID-19 pandemic, the initiative aims at helping newcomers meet their peers, navigate university bureaucracy, and familiarize themselves with Basel and the FMI.

Sciences de la vie - Campus - 5.05

Spotlight on FMIers showcases the lives, work and passions of the institute's researchers and support staff. This time, graduate student Gergely Tihanyi tells us about his love for food and cooking, and he shares his insights on the FMI Master Chef series — virtual events where FMIers come together to cook and socialize.

Sciences de la vie - 12.07
Sciences de la vie

Long considered 'junk', non-coding RNAs have emerged as important regulators of diverse cellular processes, including the silencing of genes. Working in yeast, researchers from the Bühler group have identified more than 20 mutations that enable RNA-mediated gene silencing. The findings could improve our understanding of the factors that keep gene silencing in check.

Sciences de la vie - 6.07

The governing council of Basel awarded this year's Science Prize of the city of Basel to Pico Caroni. The neurobiologist, who is a group leader at the FMI and professor of neurobiology at the University of Basel, is being honored for his life's work in basic neuroscience research - memory research in particular - and for establishing Basel as a main center for research in the field of neuronal circuits.

Sciences de la vie - 21.06
Sciences de la vie

Using miniature guts grown in a dish and 3D biophysical modelling, FMI researchers and their collaborators have uncovered the forces that give the intestinal wall its classic brushlike appearance. The findings can help to understand how the gut takes form during development — and how this process goes awry in disease.

Sciences de la vie - Psychologie - 26.05
Sciences de la vie - Psychologie

Fear protects us by making us alert to danger, but the persistence of fearful memories can lead to serious mental conditions. Now, an international team of researchers co-led by Andreas Lüthi has found that the activity of different cells in the brain's threat-detector hub regulates the switch between high and low fear states. The finding could help to understand why some individuals are more susceptible to anxiety and trauma-related disorders.

Sciences de la vie - Gestion de la recherche - 22.04

This year's recipients of the prestigious Advanced Grants from the European Research Council (ERC) have been announced today. The neurobiologist Prof. Silvia Arber, research group leader at the Friedrich Miescher Institute and the Biozentrum of the University of Basel, is among the awardees. Her funded project aims at understanding how brainstem neurons interact in the motor system to control generation and learning of body movements.

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