Postdoctoral and PhD position – Pathogen-phagocyte inter-kingdom signaling

University of Zürich
Institute of Medical Microbiology

Lieu de travailZürich, Gloriastrasse 30, Région de Zurich, Suisse
Durée2-4 Jahre
Taux d'occupation
Début de l'engagementJuly 1st 2021, or per agreement

The University of Zürich is an academic research and teaching institution of international standing.


The environmental bacterium Legionella pneumophila causes a severe pneumonia termed Legionnaires’ disease in humans and forms a unique replication-permissive vacuole in amoebae and macrophages. Pathogen-host cell interactions are governed by more than 300 different secreted bacterial "effector" proteins as well as by a small signaling molecule called LAI-1 (Legionella autoinducer-1). LAI-1 promotes inter-bacterial communication (quorum sensing) as well as prokaryote-eukaryote trans-kingdom signaling.
The project funded by the Swiss National Science Foundation aims at elucidating Legionella-phagocyte trans-kingdom signaling through LAI-1. To study the production, secretion, delivery, cellular targets and mode of action of LAI-1, the successful applicants will use a broad range of techniques in the disciplines Microbiology (handling of BL-2 pathogens, infection analysis, bacterial genetics), Cell Biology (confocal fluorescence microscopy, flow cytometry, RNA interference) and Biochemistry (FPLC/HPLC, protein-ligand interactions, purification of Legionella vacuoles).


Highly motivated individuals with an interest and background in Microbiology, Cell Biology, Biochemistry or a related area are invited to apply.

Nous offrons

The positions (up to 4 years) are available at the Institute of Medical Microbiology, University of Zürich main campus, as of July 1st 2021, or upon mutual agreement.

Contact et adresse

Please send your CV with a motivation letter and the contact details of 2 references as a single pdf file to Prof. Dr. Hubert Hilbi ( For further information please contact Hubert Hilbi and visit our website (



044 634 2650


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