Incoming adenovirus particles (AdV) dock at the nuclear pore complexes of a human cell's nucleus (NPC, dashed line). The cellular enzyme Mind bomb1 (Mib1, grey-white structures) primes them for unlocking and removes protein V (GFP-V, green dots). The uncoated viral DNA genome is then imported into the nucleus. The arrow highlights a virus particle containing both protein V and Mib1, yellow denotes particles containing protein V, and red shows particles lacking V and Mib1. (Image: Michael Bauer/Alfonso Gomez-Gonzalez, UZH)
Incoming adenovirus particles (AdV) dock at the nuclear pore complexes of a human cell's nucleus (NPC, dashed line). The cellular enzyme Mind bomb1 (Mib1, grey-white structures) primes them for unlocking and removes protein V (GFP-V, green dots ). The uncoated viral DNA genome is then imported into the nucleus. The arrow highlights a virus particle containing both protein V and Mib1, yellow denotes particles containing protein V, and red shows particles lacking V and Mib1. (Image: Michael Bauer/Alfonso Gomez-Gonzalez, UZH) - Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell's nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses.
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