Cell senescence is regulated by innate DNA sensing

EPFL scientists have made new insights into the control of cell senescence, which is intimately linked to the development of cancer and ageing. Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old". Understanding the causes and impact of senescence can give us deep insights into the development of cancer and ageing. EPFL scientists have now discovered that a DNA-sensing mechanism of the innate immune system - which is pivotal for the immediate defense against pathogens - controls cellular senescence. The work is published , and highlights potential novel anti-tumor and perhaps anti-ageing strategies. When cells senesce, they undergo profound changes, including the secretion of several inflammation-mediating proteins (cytokines, chemokines, extracellular-matrix proteins, growth factors).