Lung cancer resistance: the key is glucose

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Histological staining of a lung adenocarcinoma, which is made of tumor cells as
Histological staining of a lung adenocarcinoma, which is made of tumor cells as well as cells of the immune microenvironment including tumor-associated neutrophils. Credit: Caroline Contat (EPFL).
Histological staining of a lung adenocarcinoma, which is made of tumor cells as well as cells of the immune microenvironment including tumor-associated neutrophils. Credit: Caroline Contat (EPFL). Lung tumors are home to immune cells that affect their growth and resistance to treatment. Looking at neutrophils, scientists led by EPFL have discovered that the key might lie in the cells' ability to metabolize glucose, opening an entirely new target for improving radiotherapy. Cancers are not only made of tumor cells. In fact, as they grow, they develop an entire cellular ecosystem within and around them. This "tumor microenvironment" is made up of multiple cell types, including cells of the immune system, like T lymphocytes and neutrophils.
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