Two Postdoctoral Positions: Splicing Factor Dysfunctions in Cancer

EmployerEidgenossische Technische Hochschule Zürich, ETHZ
WorkplaceZurich, Zurich region, Switzerland
CategoryMedicine / Pharmacology
Life Sciences
PositionSenior Researcher / Postdoc


Applications are invited for two postdoctoral positions available in the Laboratory of Cell Signaling and Disease Biology (Prof. Dr. W. Krek) at the Institute of Molecular Health Sciences at ETH Zurich (?" target="_blank" rel="nofollow">

The prime interest of the Laboratory of Cell Signaling and Disease Biology is to investigate how cancer cell signalling abnormalities and tumor local environmental cues (e. g. nutrients and oxygen) converge to promote tumor development and resistance and to convert elements of our fundamental discoveries into new precision cancer medicines. Our approaches involve a broad range of molecular, cellular and genomic methods, the construction of mouse models of human cancers that recapitulate key characteristics of tumorigenesis and cancer drug resistance and the utilization of tumor organoids and various screening modalities to translate our findings into new treatment options for human cancer. Based on our original discovery establishing a direct link between tissue hypoxia and the key components of the core splicing machinery in the regulation of fructose metabolism (Mirtschink et al., Nature 2015), the successful candidates will investigate the collaborative impact of hypoxia, splicing factor dysfunctions and metabolism in the context of pancreatic tumor development and spread. These investigations will involve systematic and functional studies in advanced cell systems (mouse and human organoids) and a series of existing, unique genetically-engineered mouse models of pancreatic cancer. State-of-the-art technologies to execute these projects are available through ETH technology platforms (e. g. NEXUS, ScopeM, Functional Genomics Center, ETH Phenomics Center). The position offers excellent scientific opportunities in a highly stimulating and interdisciplinary environment involving close interactions between scientists from different disciplines.

Applicants should hold a MD, MD/PhD or PhD degree with a strong background in (mouse) genetics, molecular biology and/or genomic analyses, be highly motivated, dedicated to perform research at the highest quality and level and excited about science. The position is located at the newly-built Institute of Molecular Health Sciences at the ETH Hönggerberg, a world-leading institution in basic and applied research.

In your application, please refer to
and reference  JobID 37389.

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