Postdoctoral Position: Oncogenic Splicing Factors and Cancer Metabolism

EmployerEidgenossische Technische Hochschule Zürich, ETHZ
WorkplaceZurich, Zurich region, Switzerland
CategoryMedicine / Pharmacology
Life Sciences
PositionSenior Researcher / Postdoc


Applications are invited for a postdoctoral position available in the Laboratory of Cell Signaling and Disease Biology (Prof. Dr. W. Krek) at the Institute of Molecular Health Sciences at ETH Zurich.

The Laboratory of Cell Signaling and Disease Biology investigates how cancer cell signaling abnormalities and tumor local environmental cues in particular hypoxia converge to promote tumor development, spread and resistance. Our approaches involve a broad range of molecular, cellular and genomic methods, the utilization of tumor organoids and the construction of mouse models of human cancers that recapitulate key characteristics of tumorigenesis. In this context, the laboratory has generated a series of unique genetic mouse models of pancreatic cancer with defined mutations in splicing factors recurrently mutated in human pancreatic cancer.

The successful candidate will explore the functions of clinically-relevant splicing factor mutations on metabolism, cell signaling, transcription and stem cell function in pancreatic cancer and during metastatic spread. Full access to state-of-the-art technologies to execute this project are available through ETH Technology platforms (e. g. NEXUS, ScopeM, Functional Genomics Center Zurich, ETH Phenomics Center). The position offers excellent scientific opportunities in a highly stimulating and interdisciplinary environment involving close interactions between scientists from different disciplines.

Applicants should hold a PhD, MD/PhD or MD degree with a strong background in mouse genetics, handling and analyses, molecular and biology, be highly motivated, dedicated to perform research at the highest quality and level and excited about science. The position is located at the newly-built Institute of Molecular Health Sciences at the ETH Hönggerberg, a world-leading institution in basic and applied research.

In your application, please refer to
and reference  JobID 38026.

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