Post-doctoral scientist in Neuromodulation of Neocortical Microcircuits (W/M)



WorkplaceLausanne, Lake Geneva region, Switzerland


The Ecole polytechnique fédérale de Lausanne (EPFL) is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs 6,000 people supporting the three main missions of the institutions: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of 16,000 people, including over 10,000 students and 3,500 researchers from 120 different countries.

Post-doctoral scientist in Neuromodulation of Neocortical Microcircuits (W/M)

The EPFL Blue Brain Project (BBP), situated on the Campus Biotech in Geneva, Switzerland, applies advanced neuroinformatics, data analytics, high-performance computing and simulation-based approaches to the challenge of understanding the structure and function of the mammalian brain in health and disease. The BBP provides the community with regular releases of data, models and tools to accelerate neuroscience discovery and clinical translation through open science and global collaboration.

For our Circuits team, we are currently seeking a: Post-doctoral scientist in Neuromodulation of Neocortical Microcircuits (W/M).

The goal of this project is to characterize the effects of acetylcholine on the anatomy and physiology of cells, synapses and microcircuits in the neocortex using transgenic mouse lines.

Main duties and responsibilities include :
  • Responsible for dissecting the anatomy and physiology of cholinergic projections to the neocortex and effects on cells, synapses, and microcircuit activity using viral manipulations, optogenetics, and whole-cell recordings in brain slices in vitro and the intact brain in vivo.
  • Collaborate with researchers in Blue Brain’s simulation division that will integrate these data into computational models to predict the mechanisms by which acetylcholine controls transitions between brain states.

Your profile :
  • PhD in Biology, Neuroscience, or related fields
  • Background in Neurobiology research
  • Knowledge of electrophysiology, optogenetics, imaging, and standard laboratory protocols
  • Experience in scientific research of rodent animal models
  • Strong team player and fluent English in speech and writing
  • Background in cortical/neuromodulation research
  • Experience in multiple patch clamp electrophysiology
  • Experience in calcium imaging and/or optogenetics
  • Experience in rodent stereotaxic manipulations
  • Experience in brain clearing and whole brain imaging methods
  • Knowledge of scientific computing software (python, C++)

We offer :
  • An internationally visible and rising project in simulation-based research in neuroscience using supercomputers,
  • A young, dynamic, inter-disciplinary, and international working environment,
  • A modern working environment, based at Biotech Campus in Geneva Sécheron.

Start date :
As soon as possible

Term of employment :
Fixed-term (CDD)

Duration :
1 year, renewable

For additional information, please contact Dr. Srikanth Ramaswamy by e-mail srikanth.ramaswamy [at] epfl[.]ch or Dr. Rodrigo Perin by e-mail rodrigo.perin [at] epfl[.]ch

Remark :
Only candidates who applied through EPFL website or our partner Jobup’s website will be considered.


In your application, please refer to and reference JobID 44115.

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