Bioinformatics and Molecular Modelling Specialist in Process Chemistry & Catalysis (two years temporary)

     
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Bioinformatics and Molecular Modelling Specialist in Process Chemistry & Catalysis (two years temporary)

Switzerland, Basel-City, Basel

Bioinformatics and Molecular Modelling Specialist in Process Chemistry & Catalysis (PTDC-C)  // Temporary Position for two years

At Roche, we believe it is urgent to deliver medical solutions right now - even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

As a Scientist in Process Chemistry you will be working in the department "Process Chemistry & Catalysis" within the unit "Small Molecules Technical Development". Behind every product sold by Roche is the strong involvement of Pharma Global Technical Operations (PT). Starting with Phase 1 of the clinical development process and continuing through to product maturity, PT makes medicines at sites around the world and includes more than 10.000 employees worldwide.

In Small Molecules Technical Development (PTDC) as part of the Global Technical Development (PTD) unit we bring a broad range of experience across drug substance (DS), drug product (DP), analytical sciences and manufacturing technology. We collaborate closely with key partners in the departments Research and Early Development (pRED/gRED), commercial manufacturing (PTC) and PTD and we are responsible for late stage technical development of our small molecule pipeline, manufacture of DS and DP for clinical studies and transfer of the processes to commercial manufacturing.

As a Bioinformatics and Molecular Modelling Specialist in Process Chemistry & Catalysis, you will increase the quality and diversity of our enzyme libraries, and predict in-silico crucial amino acid positions for protein engineering to increase enzyme activities and stabilities. Already for early development projects, you would design and create focused enzyme libraries based on protein structure and experimental data, modelling and simulation. The optimized enzyme secure an efficient intermediate synthesis and / or enable a new sustainable "green" synthesis route. Key tasks and responsibilities are

  • Setup of state-of-the-art software infrastructure necessary to fulfill required modeling tasks
  • Application, development and implementation of novel computational methods to leverage protein structure and experimental data for enzyme library creation and enzyme engineering
  • In-silico enzyme database screening as well as predictions for enzyme engineering to increase activity, selectivity and stability using structure-based computational chemistry techniques

As a Scientist in Process Chemistry & Catalysis you both hold a PhD degree and have conducted postdoctoral studies in bioinformatics, computational biology, computational chemistry or a related field. These competences are demonstrated by publication in scientific peer-reviewed journals and/or patents. Other requirements are:

  • Familiarity with state-of-the-art bioinformatics, computational biology,  and databases (SQL and/or MongoDB)
  • Experience in modeling, de novo prediction, visualization and analysis of protein structures, small molecule docking and molecular dynamics of protein-ligand complexes
  • Experience in biological sequence analysis, including multiple sequence alignment, phylogenetic reconstruction, sequence similarity clustering and profiling.
  • Experience and proven expertise in analysis of large datasets and automation of workflows
  • Programming experience in scripting languages (Perl, Python, R) and/or pipelining tools (Knime, Pipeline Pilot)
  • Good knowledge in statistics and being able to apply it to experimental design and analysis
  • You are an excellent team player and have very good coordination and communication skills with proficiency in English and German

Y ou are applying to be part of the Roche Talent Pool. Currently we do not have a vacant role however we are building a pipeline for future opportunities and therefore we are very interested to get in touch with you.

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In your application, please refer to myScience.ch and reference JobID 46351.


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