2 year (possibility/potential for a 3rd year extension)
June 1, 2021 or date to be agreed upon
The faculty of Medicine of the University of Geneva benefits from a multicultural environment and contributes to different missions and activities, such as teaching and research, together with the University Hospitals of Geneva, to which the faculty is linked.
In order to strengthen its team, the Center for Vaccinology/ Department of Pathology and Immunology, is looking for a dynamic and full-time Post-doctoral fellow in the laboratory of Prof. A. Didierlaurent.
The selected candidate will assume, under the responsibility of the professor, research activities in Human Vaccine Immunology.
Professor A. Didierlaurent is part of the Center of Vaccinology led by the Professor Claire-Anne Siegrist’s research group, hosted at the University Medical Center, close to the University Hospital (HUG). This team has a solid world-renowned track-record in fundamental vaccine immunology research and clinical studies.
The postdoctoral fellow will be leading the evaluation of the immune response to COVID-19 vaccines. In collaboration with the Rheumatology and Neuro-immunology departments at the HUG and Dr. Christiane Eberhardt in the Center of vaccinology, an observational clinical study is currently ongoing in patients under specific active immunosuppression vaccinated with mRNA vaccines against SARS-Cov2. The project will mainly consist of in-depth analysis of vaccine response in vaccinated individuals, with a focus on understanding how the potential alteration in innate immune response impacts on the magnitude and quality of the vaccine response. The postdoctoral fellow is expected to establish immune innate read-outs (phenotyping and activation), gene profiling (in whole blood or isolated cells by RNAseq), and to perform tests evaluating adaptive immune response and develop assays at the innate and adaptive interface, such as ADCC. He/she will define strategies for data integration and multiparametric analysis, with the support of a bio-informatician present in the laboratory.
The University of Geneva offers access to cutting-edge technical platforms, including flow cytometry, genomics facilities.
The project will generate critical data in order to adapt current vaccination strategies in these populations who remain vulnerable to SARS-CoV2 infection. The candidate will also contribute to future translational research programs aimed at studying the effect of immunosuppressive drugs on responses to different vaccines and associated mechanisms.
Applicants should hold a PhD in immunology or related field (e.g. innate immunity, vaccinology) and should have a solid research background in human immunology. Technical expertise with flow cytometry (e.g. setting up of complex marker panels) and experience/good understanding of data analysis/data integration (“system biology”) are required.
The Faculty of Medicine offers a cutting-edge scientific research environment. Scientific exchange within the Pathology and Immunology Department, which conducts research into anatomical and clinical correlations in human pathology, in the fields of cell biology, general immunology and immunopathology. Participation in a challending research project within Prof. Didierlaurent’s laboratory, who targets his research on Translational vaccine immunology.
Contact and Address
For any further information, please contact Arnaud.Didierlaurentunige.ch. Should you correspond to above profile, we will be happy to receive your complete application file as soon as possible (motivation letter, CV with picture and list of publications, diplomas and references), which will be handled confidentially.