The faculty of Medicine of the University of Geneva benefits from a multicultural environment and contributes to different missions and activities, such as teaching and research, together with the University Hospitals of Geneva, to which the faculty is linked.
In order to strengthen its team, the Center for Vaccinology/ Department of Pathology and Immunology, is looking for a dynamic and full-time Post-doctoral fellow in the laboratory of Claire-Anne Siegrist, under the supervision of Dr. Christiane Eberhardt, a physician-scientist with extensive experience in basic research on adaptive responses to vaccines and infectious agents. The laboratory has a solid world-renowned track-record in basic vaccine immunology research and clinical studies.
The selected candidate will be mainly responsible for the thorough evaluation of antigen-specific CD4 and CD8 T cell responses, in the context of vaccination and in comparison with the corresponding infection, by flow cytometry (such as AIM assay, ICS, tetramers), genetic analysis (RNAseq, TCR repertoire) and in vitro functional tests. Part of the work will be done in already established cohorts on SARS-CoV-2 infection and vaccination in patients with and without comorbidities and in collaboration with the laboratory of Prof Arnaud Didierlaurent at the Center for Vaccinology. Subsequently, future research projects are planned, comparing adaptive immune responses to other infectious agents and their corresponding vaccination, such as human papillomavirus, influenza and varicella virus in pediatric and adult cohorts. These data on differences in memory responses elicited by infection and vaccination and will help better understand short comings in vaccination and help inform better designs of current and future vaccines.
Applicants should hold a PhD in immunology or another related field (vaccinology, infectious diseases, oncology) and should have a strong background in human adaptive immune responses. They should have at least 3 years of experience in scientific research with first author publications, an excellent level of written and spoken English (minimum level B2), very good communication and organizational skills. Experience and technical knowledge in flow cytometry, including detailed analysis of antigen-specific T-cell responses are highly appreciated, and bioinformatic skills would be an advantage.
The Faculty of Medicine offers a cutting-edge scientific and muticultural research environment, with scientific exchange within the Pathology and Immunology Department, which conducts research into anatomical and clinical correlations in human pathology, in the fields of cell biology, general immunology and immunopathology. We offer participation in a challending research project within Prof. C.A. Siegrist’s laboratory, who has a solid world-renowned track-record in basic vaccine immunology research and clinical studies.
Contact and Address
For any further information, please contact Christiane.Eberhardtunige.ch. Should you correspond to above profile, we will be happy to receive your complete application file as soon as possible (motivation letter, CV with picture and list of publications, diplomas and references), which will be handled confidentially.