Postdoctoral position in DEL-technology

Postdoctoral position in DEL-technology

100%, Zurich, fixed-term

In the frame of a Roche-postdoc fellowship project, a 2-year postdoctoral fellow position is open with immediate effect. You will be employed by ETH and work on dedicated encoding systems and the construction of novel DNA-encoded chemical libraries for screening against relevant target proteins and receptors.

Project background

The DEL technology group is led by Priv-Doz. Dr Jörg Scheuermann at ETH Zürich, Switzerland, is seeking a highly motivated, curious and innovative post-doctoral individual. The position is funded by a collaboration between ETH Zürich and Roche. You will work on DEL of various chemical and encoding designs to find ligands to therapeutically relevant proteins.

Job description

You will:

• design, synthesize and screen novel DNA-encoded chemical libraries (DELs) against proteins of therapeutic interest.
• explore and compare different encoding strategies.
• contribute both experimentally and intellectually to an early drug discovery project by collaborating with teams at ETH Zürich and Roche (Basel).
• present results at internal and external meeting and in scientific publications.
• be an active member of the lab organization – mentoring junior colleagues / maintaining equipment.

Your profile

• you hold a PhD with a strong background in either chemical biology, chemistry, or applied pharmaceutical sciences.
• you have practical knowledge of DNA-encoded chemical library technology and a strong motivation to explore further the possibilities of DEL technology.
• you are curious and you have an interdisciplinary mindset.
• you are interested in working in open and collaborative teams and you possess excellent interpersonal skills.
• you can adapt to scientific challenges and generate innovative ideas/solutions.
• you can communicate and clearly present your work in oral and written English.

additional advantages:

• you have already constructed and screened DEL(s).
• you have experience with dual-display systems and DEL encoding systems.
• you have experience with large datasets analysis.
• you have prior expertise in drug discovery: identification and characterization of LMW ligands, exploration at the interface between chemistry and biology.

We offer

ETH Zurich is a family-friendly employer with excellent working conditions. You can look forward to an exciting working environment, cultural diversity and attractive offers and benefits.

Working, teaching and research at ETH Zurich

We value diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving your online application with the following documents:

• CV and motivation letter
• copy of your PhD certificate
• reference letter of your PhD supervisor
• if possible, copy or link to your PhD thesis

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about DNA-encoded Chemical Libraries/DEL technology can be found on our website .

Apply online now

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