Actelion ensures his future with Macitentan
- EN - DE
Actelion announced today that initial analysis indicates that the pivotal, long-term, event-driven study SERAPHIN with macitentan, a novel dual endothelin receptor antagonist, in 742 patients suffering from pulmonary arterial hypertension (PAH) and treated for up to three and a half years, has met its primary endpoint. Macitentan, at both the 3 mg and 10 mg dose, decreased the risk of a morbidity/mortality event over the treatment period versus placebo. This risk was reduced by 45 percent in the 10 mg dose group (p<0. At 3 mg, the observed risk reduction was 30 percent (p=0. Treatment with macitentan in the SERAPHIN study was well tolerated. Jean-Paul Clozel, M.D. and Chief Executive Officer of Actelion commented: "I am extremely pleased with the outstanding SERAPHIN results. We are committed to working with the Health Authorities to bring this potentially important advancement in PAH to patients as soon as possible.
