Mechanically compressed human cell under a microscope. (Photograph: Lomakin et al. 2020).
Mechanically compressed human cell under a microscope. (Photograph: Lomakin et al. Many cells in the body must pass through tissue, which sometimes requires them to get out of tight corners. An international research team co-led by ETH Zurich has now examined how cells recognise and escape from such bottlenecks. Among the results of the team's work are new pointers for how to improve immunotherapy. In the human body, the cells that make up our skin, bones, blood vessels and organs sit tightly together - 100 trillion of them in each of us. Some cells have to be able to wriggle out of this jam-packed environment - especially immune cells, which patrol through tissue to hunt down pathogens and defective cells.
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