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Health - Pharmacology - 24.11.2022
Protein shapes indicate Parkinson’s disease
Researchers have found that a set of proteins have different shapes in the spinal fluid of healthy individuals and Parkinson's patients. These could be used in the future as a new type of biomarker for this disease. Many human diseases can be detected and diagnosed using biomarkers in blood or other body fluids.

Health - Pharmacology - 16.11.2022
How an Emerging Drug Class Dampens Harmful Immune Reactions
Although the complement system forms part of the innate immune system, it can cause damage to the body in some cases. This is because unwanted complement activation contributes to many autoimmune and chronic inflammatory diseases. Now, researchers have described molecular details of a recently approved class of drugs that can inhibit the complement system.

Health - Pharmacology - 15.11.2022
Improving Diagnosis for Extrapulmonary Tuberculosis
Improving Diagnosis for Extrapulmonary Tuberculosis
Tuberculosis (TB) remains one of the world's biggest infectious disease killers. It is a complicated disease to diagnose and treat, even more so when it affects organs outside of the lung. A clinical trial in Tanzania tested a diagnostic algorithm including point-of-care ultrasound to increase the proportion of correctly managed patients.

Health - Pharmacology - 09.11.2022
A new nanoparticle to act at the heart of cells
A new nanoparticle to act at the heart of cells
A team from the University of Geneva and LMU developed a transport nanoparticle to make an anti-inflammatory drug much more effective and less toxic. How can a drug be delivered exactly where it is needed, while limiting the risk of side effects? The use of nanoparticles to encapsulate a drug to protect it and the body until it reaches its point of action is being increasingly studied.

Pharmacology - Health - 27.10.2022
Vodka, Benzodiazepines & Co: A Dangerous Mix for Young People
At least 33 young people have died from polydrug use in Switzerland since 2018. Polydrug use refers to taking two or more psychoactive substances at the same time. The young adults are often unaware of the associated risks and rarely use the available services to minimize the risks, the initial results of a study by the Swiss Research Institute for Public Health and Addiction (IGSF) and the University of Zurich have shown.

Health - Pharmacology - 05.07.2022
How Omicron dodges the immune system
How Omicron dodges the immune system
By comparing the neutralisation capacity induced by the different variants of SARS-CoV-2, a team from the UNIGE and the HUG reveals the exceptional capacity of Omicron to evade our immunity. The current wave of COVID-19 highlights a particularly high risk of reinfection by the Omicron variant of SARS-CoV-2.

Pharmacology - 27.06.2022
Opioid poisoning on the rise
Researchers at ETH have shown that cases of opioid poisoning and the prescription of opioids have increased sharply in Switzerland over the past 20 years. Although the situation is not as serious as in North America, the risk should not be underestimated. Since the early 2000-s the US has been in the grip of an opioid crisis that has been exacerbated by the Covid pandemic - in 2021, more than 100,000 people died of an opioid overdose in the country.

Health - Pharmacology - 27.06.2022
Nitric Oxide Does Not Improve Babies' Recovery after Heart Surgery
Nitric Oxide Does Not Improve Babies’ Recovery after Heart Surgery
Infants undergoing heart surgery are connected to a heart-lung machine and given nitric oxide as an anti-inflammatory. Researchers from the Universities of Zurich and Queensland have now conducted the world's largest study of its kind, showing that using nitric oxide does not improve children's recovery after surgery.

Health - Pharmacology - 16.06.2022
Breakthrough study of hormone 'crosstalk' in breast cancer
Breakthrough study of hormone ’crosstalk’ in breast cancer
Scientists led by EPFL have successfully engrafted breast cancer cells on mice, allowing them to study in vivo the cross-talk between the estrogen and progesterone receptors that hampers hormone therapies. Their findings suggest that endocrine therapy may need to be personalized, and that abrogating progesterone receptor expression can be a therapeutic option.

Pharmacology - Life Sciences - 13.06.2022
An anti-cancer drug acts as an epigenetic memory aid, scientists find
An anti-cancer drug acts as an epigenetic memory aid, scientists find
Scientists have discovered how an anti-cancer drug could be repurposed to improve memory. It does so by supporting the cell's ability to read the very genes that are important for learning. The epigenetic mechanism of the drug is shown in mice. If you are scared of spiders, you may soon benefit from a drug to enhance your ability to unlearn your arachnophobia, without any undesirable side-effects.

Health - Pharmacology - 31.05.2022
A World Premiere: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
A World Premiere: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
The multidisciplinary Zurich research team Liver4Life has succeeded in doing something during a treatment attempt that had never been achieved in the history of medicine until now: it treated an originally damaged human liver in a machine for three days outside of a body and then implanted the recovered organ into a cancer patient.

Health - Pharmacology - 11.05.2022
The combination makes the difference: New therapeutic approach against breast cancer
The combination makes the difference: New therapeutic approach against breast cancer
Some breast tumors with certain genetic alterations are difficult to treat using existing therapies. Researchers at the University of Basel have now discovered an approach that involves a toxic combination with a second target gene in order to kill the abnormal cells. The first clinical trials could be starting soon.

Pharmacology - Health - 09.05.2022
Lymphomas: new model developed at the IOR against drug resistance
Lymphomas: new model developed at the IOR against drug resistance
The Lymphoma Genomics group, directed by Prof. Francesco Bertoni at the Institute of Oncology Research (IOR, affiliated to USI and member of Bios+), identified a new mechanism behind the resistance to the drug idelalisib, used in the treatment of patients with follicular lymphoma and marginal zone lymphoma.

Environment - Pharmacology - 02.05.2022
Bioassays evaluate ozonation and post-treatment of wastewater
Bioassays evaluate ozonation and post-treatment of wastewater
Through wastewater, rivers and lakes are polluted with numerous micropollutants which originate from care products and pharmaceuticals, among other things. The Waters Protection Act therefore aims to expand Swiss wastewater treatment plants (WWTP) with the addition of a further treatment step. In pilot tests, two processes have proven particularly successful in the removal of trace substances: ozonation and treatment with activated carbon.

Health - Pharmacology - 25.04.2022
Retina is not sparged by SARS-CoV-2
Retina is not sparged by SARS-CoV-2
The list of diseases caused by SARS-CoV-2 infection is growing and now includes the retina. This is what suggest a prospective study by the Geneva University Hospitals (HUG) and the University of Geneva. The list of diseases caused by SARS-CoV-2 infection is growing and now includes the retina. This is what suggest a prospective study by the Geneva University Hospitals (HUG) and the University of Geneva , in collaboration with the Adolphe de Rothschild Memorial Clinical Research Center for Ophthalmology.

Health - Pharmacology - 21.04.2022
Targeting ’anti-tumor’ genes to provide better treatment for leukemia
Scientists discuss the possibility of offering personalized treatment for chronic lymphocytic leukemia by regulating the expression of a gene known for its "anti-tumorous" properties. Chronic lymphocytic leukemia (CLL) is one of the most common blood cancers in adults. The disease originates in B cells - the part of the immune system that produces antibodies - and then evolves slowly, typically affecting older people.

Health - Pharmacology - 12.04.2022
COVID-19: Vaccination greatly reduces infectious viral load
By comparing the infectious viral load caused by ancestral SARS-CoV-2 as well as by the Delta and Omicron variants, scientists from the University of Geneva and HUG highlight the benefits of vaccination. To conduct the research, the UNIGE and HUG team was able to reanalyze samples from previous waves of the disease.

Pharmacology - Health - 29.03.2022
An approach to treating a severe congenital myopathy
An approach to treating a severe congenital myopathy
The diagnosis is rare, but devastating - children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital Basel are now presenting a possible therapeutic approach for the first time. Professor Susan Treves remembers seeing one child affected by the condition at the age of six months.

Health - Pharmacology - 08.03.2022
Origins of metastasis
Origins of metastasis
Researchers at the University of Geneva show that the experience of impending cell death within a primary  tumour can lead to the development of «pro-metastatic» cells. Metastatic cells form in a primary tumour and then break away from it, migrate to other organs, attach to them and form new tumours.

Pharmacology - Health - 17.02.2022
Defeating leukaemia cells by depriving them of energy
Defeating leukaemia cells by depriving them of energy
A Swiss-French team that includes scientists has discovered how to trigger apoptosis in leukaemia cells by disrupting their energy maintenance mechanism. Acute myeloid leukaemia, which affects blood and bone marrow cells, is a particularly dangerous form of cancer. More than half of patients under the age of 60 die.