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Health - Pharmacology - 04.07.2024
New anti-aging therapy identified
New anti-aging therapy identified
Scientists from USI in collaboration with italian scientists have made a significant discovery by identifying a novel anti-aging therapeutic. The study is published in the prestigious journal "Nature Aging". Aging is a primary risk factor for the development of numerous chronic diseases such as Alzheimer's disease, arthritis, chronic kidney disease and cancer.

Health - Pharmacology - 01.07.2024
Novel Blood Test Helps Improve Cancer Treatments
Novel Blood Test Helps Improve Cancer Treatments
Oncologists use biopsy and imaging techniques to diagnose and monitor tumor diseases and assess treatment success. UZH and USZ researchers have now further developed an advanced method to analyze liquid biopsies of DNA fragments in the blood. It is fast and practical, without putting much of a strain on patients.

Pharmacology - Health - 01.07.2024
Physical exercise prevents nerve damage during chemotherapy
Physical exercise prevents nerve damage during chemotherapy
Cancer treatments often cause nerve damage that can lead to long-lasting symptoms. Medication has proven ineffective in these cases. A sports scientist at the University of Basel, together with an interdisciplinary team from Germany, has now shown that simple exercises can prevent nerve damage. Cancer therapies have improved over the years.

Health - Pharmacology - 27.06.2024
The Mechanism Behind Melanoma Resistance to Treatment
In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings could pave the way for more effective therapies. Malignant melanoma is one of the most aggressive types of cancer.

Health - Pharmacology - 26.06.2024
New findings on skin disinfection before operations
New findings on skin disinfection before operations
Surgery carries the risk of infection at the surgical site. Proper skin disinfection before the incision minimizes this risk. Two disinfectants are used worldwide for this purpose, one of which was previously considered to be better. A joint study by Inselspital, Bern University Hospital and the University of Bern in collaboration with the University Hospitals of Basel and Zurich now shows that both agents are equally effective.

Pharmacology - Life Sciences - 21.06.2024
Membrane protein analogues could accelerate drug discovery
Membrane protein analogues could accelerate drug discovery
Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these proteins from cell membranes. Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

Health - Pharmacology - 20.06.2024
Antibiotic resistance: concerning situation in sub-Saharan African children
Antibiotic resistance: concerning situation in sub-Saharan African children
Focusing on enterobacteria, two studies by the University of Geneva and the HUG highlight the alarming situation in this region of the world in terms of antibiotic resistance. Enterobacteriaceae are commensal bacteria of the digestive flora that can be responsible for serious infections. HUG Two meta-analysis undertaken by the Geneva University Hospital (HUG) and the University of Geneva have revealed very worrying numbers of children in Sub-Saharan Africa who are carriers of multi-resistant bacterial strains.

Health - Pharmacology - 03.06.2024
Antibody-peptide inhibitor conjugates: a new path for cancer therapy
Antibody-peptide inhibitor conjugates: a new path for cancer therapy
Cancer treatments often struggle with balancing efficacy and side effects. A new study by scientists offers a promising solution using antibody-peptide inhibitor conjugates to target specific cell types and block the activity of cancer-promoting enzymes called cathepsins. Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions.

Health - Pharmacology - 23.05.2024
New approach to Epstein-Barr virus and resulting diseases
New approach to Epstein-Barr virus and resulting diseases
The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers. Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease, as reported by researchers from the University of Basel and the University Hospital Basel in the journal Science.

Health - Pharmacology - 22.05.2024
Gentler cell therapies for blood cancer
Researchers have developed an approach to -deleting- a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in the journal Nature, the team reports on the promising results obtained in animal experiments and with human cells in the laboratory.

Health - Pharmacology - 16.05.2024
At the right time for tumours
By examining the immune modulations of tumours during the day, scientists from the University of Geneva and the LMU Munich are demonstrating their impact on the diagnosis and management of patients. The currently most promising anti-tumour treatments are immunotherapies, which aim to boost the action of the patients' immune system to fight cancer.

Pharmacology - Chemistry - 24.04.2024
AI designs new drugs based on protein structures
AI designs new drugs based on protein structures
A new computer process developed by chemists at ETH Zurich makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process could revolutionise drug research. "It's a real breakthrough for drug discovery," says Gisbert Schneider, Professor at ETH Zurich's Department of Chemistry and Applied Biosciences.

Pharmacology - Health - 03.04.2024
New Discovery Unravels Malaria Invasion Mechanism
New Discovery Unravels Malaria Invasion Mechanism
A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study, led by the Swiss Tropical and Public Health Institute (Swiss TPH) and Griffith University's Institute for Glycomics, reveals the role of a sugar called sialic acid in this invasion process.

Health - Pharmacology - 21.03.2024
An Immunotherapy to Overcome Resistant Leukemia
An Immunotherapy to Overcome Resistant Leukemia
Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working. Their study also explains why the cancer cells are resistant and how this resistance can be overcome: through concomitant pharmacotherapy or genetically improved CAR T-cells.

Health - Pharmacology - 19.03.2024
Fighting heart attack down to the smallest vessels
Fighting heart attack down to the smallest vessels
Researchers in Bern have co-developed and tested a new method to combat the blockage of tiny coronary arteries after a heart attack. The new approach, born from a cooperation of engineers, clinicians, and industry, offers a treatment option to prevent the death of heart tissue after a heart attack, responsible for poor long-term patient health.

Environment - Pharmacology - 05.03.2024
More targeted treatment of industrial wastewater thanks to aquatic research
More targeted treatment of industrial wastewater thanks to aquatic research
In Switzerland, wastewater treatment has traditionally focused on domestic wastewater - in particular, removal of the nutrients nitrogen and phosphorus. Only more recently has attention also been focused on problematic residues of medicines, pesticides and other chemicals. A new Eawag study, commissioned by the federal authorities, now shows that there is also potential for improvement in the case of emissions from chemical and pharmaceutical plants - both at wastewater treatment plants and within the industrial facilities.

Physics - Pharmacology - 29.02.2024
Cause of clogged hypodermic needles discovered
Cause of clogged hypodermic needles discovered
Researchers at the Paul Scherrer Institute PSI and the ANAXAM technology transfer center have used neutron and synchrotron imaging to determine the conditions under which pre-filled syringes become blocked. In very rare cases, the needles of prefilled syringes may become blocked. This can have potentially detrimental consequences for patients if their medication does not enter the body or the dosage is too low.

Life Sciences - Pharmacology - 02.02.2024
Scientists successfully simulate protein complex that initiates fertilisation
Scientists successfully simulate protein complex that initiates fertilisation
Researchers at ETH Zurich recently developed highly realistic simulations of the proteins on sperm and egg cells coupling together before they fuse. These findings enabled the research team to solve several mysteries of fertilisation at once, which could help to accelerate development of more targeted infertility treatments.

Pharmacology - Health - 24.01.2024
Innovative dengue vaccine successfully tested
Innovative dengue vaccine successfully tested
Unisanté (University of Lausanne) has conducted a clinical study on a new type of vaccine that induces cellular immunity to combat dengue fever. The results have just been published in The Lancet eBioMedicine. They are positive and encourage further investigation. This approach is also promising for other diseases.

Pharmacology - Chemistry - 22.01.2024
New agent blocks stress response
New agent blocks stress response
If the body's natural stress response gets knocked off balance, it can result in physical and mental health disorders. Researchers at ETH Zurich have developed an agent capable of selectively inhibiting this response. Stress isn't merely an oppressive feeling we experience when we're overwhelmed; it's the body's natural reaction to acute or persistent strain.