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Life Sciences
22.01.2018
Combination of Resistance Genes Offers Better Protection for Wheat against Powdery Mildew
Combination of Resistance Genes Offers Better Protection for Wheat against Powdery Mildew
A decent wheat harvest requires robust wheat. However, wheat crops are often infected by fungal diseases such as powdery mildew. For several years now, UZH researchers have been investigating a wheat gene that confers resistance to powdery mildew ( Blumeria graminis f. sp. tritici ). The gene, called the Pm3 resistance gene, exists in different variations, so called alleles.
Life Sciences
18.01.2018
A new, dynamic view of chromatin movements
A new, dynamic view of chromatin movements
In cells, proteins tightly package the long thread of DNA into pearl necklace-like complexes known as chromatin.
Medicine/Pharmacology - Life Sciences
12.01.2018
Medicine/Pharmacology - Life Sciences
09.01.2018
Cluster of Resistant Tuberculosis Pathogen Discovered
Cluster of Resistant Tuberculosis Pathogen Discovered
Resistant tuberculosis pathogens are a regular part of the day-to-day business at the Swiss National Center for Mycobacteria (NZM) at the University of Zurich. And yet, the Mycobacterium tuberculosis found in a Somali asylum seeker in the refugee center in Chiasso in February 2016 was extraordinary: “These bacteria exhibited a new combination of resistance mutations against four different antibiotics that had never before been described,” says Peter Keller, Head of Diagnostics at NZM, who identified the germ.
Medicine/Pharmacology - Life Sciences
09.01.2018
New Biomarkers Predict Outcome of Cancer Immunotherapy
New Biomarkers Predict Outcome of Cancer Immunotherapy
Nowadays, melanoma and lung cancer can be combatted effectively through immunotherapy, which makes targeted use of the immune system's normal function of regularly examining the body's tissue for pathogens and damages. Specific inhibitors are used to activate immune cells in a way that makes them identify cancer cells as foreign bodies and eliminate them.
Life Sciences
08.01.2018
Survival Strategy of Messenger RNAs During Cellular Sugar Shortage
Survival Strategy of Messenger RNAs During Cellular Sugar Shortage
If a cell runs low on sugar, it stores certain messenger RNAs in order to prolong its life. As a research group at the Biozentrum of the University of Basel has now discovered, the protein Puf5p determines whether individual messenger RNAs will be stored or degraded when sugar levels are low. The study published in eLife shows that Puf5p therefore sends the messenger RNAs to a cell organelle where their fate is sealed.
Life Sciences - Environment/Sustainable Development
01.01.2018
Standardizing perovskite aging measurements
Standardizing perovskite aging measurements
EPFL scientists have produced a data-driven proposal for standardizing the measurements of perovskite solar cell stability and degradation. Published in Nature Energy , the work aims to create consensus in the field and overcome one of the major hurdles on the way to commercializing perovskite photovoltaics.
Life Sciences - Medicine/Pharmacology
27.12.2017
Bacteria acquire resistance from competitors
Bacteria acquire resistance from competitors
Bacteria not only develop resistance to antibiotics, they also can pick it up from their rivals. In a recent publication in "Cell Reports", Researchers from the Biozentrum of the University of Basel have demonstrated that some bacteria inject a toxic cocktail into their competitors causing cell lysis and death.
Medicine/Pharmacology - Life Sciences
20.12.2017
Feasibility of Eliminating Rabies in Africa
Feasibility of Eliminating Rabies in Africa
The Swiss Tropical and Public Health Institute, together with European and African collaborators, carried out a mass dog vaccination in Chad and determined its effect on human rabies exposure. The study employed a bio-mathematical method for estimating the transmission dynamics of rabies. The researchers conclude that with political will and the necessary funding, elimination of rabies is possible in Africa.
Life Sciences
20.12.2017
How Plants Form Their Seeds
How Plants Form Their Seeds
Around 80 to 85 percent of our calorie needs is covered through seeds, either directly as food or indirectly through use as feed.
Medicine/Pharmacology - Life Sciences
14.12.2017
The immune cells that help tumors instead of destroying them
The immune cells that help tumors instead of destroying them
EPFL scientists have discovered that neutrophils, a type of immune cell, can actually help lung tumors grow. The work is published in Cell Reports, and has enormous implications for cancer immunotherapy. Neutrophils inside lung adenocarcinoma tumors. On the left, neutrophils inside a mouse tumor are stained brown; on the right, neutrophils inside a human tumor are stained red (credit: E. Meylan/EPFL).
Life Sciences - Medicine/Pharmacology
13.12.2017
Protein Structure Could Unlock New Treatments for Cystic Fibrosis
Protein Structure Could Unlock New Treatments for Cystic Fibrosis
Cystic fibrosis is a severe hereditary disease of the lung, for which there is currently no cure. The underlying cause of the disease is a malfunction of the chloride channel CFTR, which prevents the secretion of chloride in certain body cells.
Life Sciences - Medicine/Pharmacology
13.12.2017
Cellular Self-Digestion Process Triggers Autoimmune Disease
Autophagy refers to a fundamental recycling process of cells that occurs in yeast, fungi, plants, as well as animals and humans. This process allows cells to degrade their own components and thus activate energy resources to be able to adapt to nutritional needs. In addition, autophagy plays a central role in steering an organism's immune response.
Medicine/Pharmacology - Life Sciences
11.12.2017
Novartis drug crizanlizumab shown to prolong time to patients’ first sickle cell pain crisis in subgroup analysis of SUSTAIN study
Investigational therapy crizanlizumab (SEG101, formerly SelG1) approximately doubled the time to first on-treatment sickle cell pain crisis, according to new subgroup analysis of Phase II SUSTAIN data Results were consistent across patient subgroups despite differences in disease severity, genotype or background therapy New findings for crizanlizumab, a potential disease-modifying, preventive treatment option for patients with sickle cell diseas
Medicine/Pharmacology - Life Sciences
11.12.2017
Liver Cancer: Lipid Synthesis Promotes Tumor Formation
Liver Cancer: Lipid Synthesis Promotes Tumor Formation
Lipid, also known as fat, is an optimal energy source and an important cell component. Much is required for the rapid and uncontrolled growth of cancer cells. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the production of lipids in liver tumors to satisfy the increased nutrient turnover and energy needs of cancer cells among other functions.
Medicine/Pharmacology - Life Sciences
06.12.2017
Healthy mitochondria could stop Alzheimer's
Healthy mitochondria could stop Alzheimer's
Using a bioinformatics and experimental approach, scientists at EPFL have found that rendering mitochondria resistant to damage can halt diseases caused by amyloid toxicity, such as Alzheimer's disease. Alzheimer's disease is the most common form of dementia and neurodegeneration worldwide. A major hallmark of the disease is the accumulation of toxic plaques in the brain, formed by the abnormal aggregation of a protein called beta-amyloid inside neurons.
Life Sciences - Medicine/Pharmacology
01.12.2017
3D-printed minifactories
3D-printed minifactories
ETH researchers have developed a biocompatible ink for 3D printing using living bacteria. This makes it possible to produce biological materials capable of breaking down toxic substances or producing high-purity cellulose for biomedical applications. There will soon be nothing that cannot be produced with 3D printing.
Life Sciences - Medicine/Pharmacology
29.11.2017
A Big Data tool begins new era for biology and personalized medicine
A Big Data tool begins new era for biology and personalized medicine
Researchers from EPFL have developed a novel series of systems genetics tools to identify new links between genes and phenotypes. The work, a hallmark of EPFL's endeavors into the advancement of open science, brings biology to the cloud and sets the stage for the development of precision medicine. The study is published in Cell Systems.
Life Sciences - Chemistry
28.11.2017
Maize pest exploits plant defense compounds to protect itself
Maize pest exploits plant defense compounds to protect itself
A new study by the Institute of Plant Sciences of the University of Bern and the Max Planck Institute for Chemical Ecology shows how the Western corn rootworm puts the maize plants' defense strategies out of action. The results explain why biological control of the crop pest has not been efficient. The Western corn rootworm continues to be on the rise in Europe.
Life Sciences
27.11.2017
Tracking Down Genetic Influences on Brain Disorders
Tracking Down Genetic Influences on Brain Disorders
New findings will help to identify the genetic causes of brain disorders: researchers at the Universities of Basel, Bonn and Cologne have presented a systematic catalog of specific variable locations in the genome that influence gene activity in the human hippocampus, as they report Communications. Individual differences in gene regulation contribute to the development of numerous multifactorial disorders.
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