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Health - Pharmacology - 16.09.2021
Improving leukemia therapy with targeted treatment approaches
In chronic leukemias, blocking the overactive kinase JAK2 by a targeted therapy approach is only mitigating the patients' symptoms, but cannot truly change the course of the disease. A study by the University of Basel has shown that it may be possible to improve the therapeutic effects by additionally inhibiting a specific signaling pathway.

Health - 09.09.2021
Statistics with a kick: Data analysis reveals cancer genes
Statistics with a kick: Data analysis reveals cancer genes
Researchers at the University of Basel have developed an analytical method to detect genes involved in the development of cancer. Using this approach, they were able to identify a number of new cancer genes, including one that plays a role in breast cancer. Tracking down as yet unknown cancer genes is the basis for discovering new targets for cancer drugs.

Health - Life Sciences - 08.09.2021
Natural Killer Cells Coordinate Wound Healing
Natural Killer Cells Coordinate Wound Healing
Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds. If the healing process is accelerated, the immune defense is weakened, researchers at the University of Zurich have now shown. This has relevance in treating skin injuries and in tackling antibiotic-resistant germs.

Health - Sport - 08.09.2021
Keep on moving: Sports relieve tumor-associated anemia
Keep on moving: Sports relieve tumor-associated anemia
Many cancer patients suffer from anemia leaving them fatigued, weak, and an impaired ability to perform physical activity. Drugs only rarely alleviate this type of anemia. Researchers at the University of Basel have now been able to show what causes the anemia, and that physical exercise can improve this condition.

Health - Pharmacology - 01.09.2021
Nasal cartilage relieves osteoarthritis in the knee
Nasal cartilage relieves osteoarthritis in the knee
Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee - according to researchers from the University of Basel and the University Hospital Basel, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation.

Life Sciences - Health - 31.08.2021
How to produce proteins at the right speed
How to produce proteins at the right speed
Using a dynamic observation technique of protein synthesis, scientists from the University of Geneva have deciphered the genetic mechanisms governing the speed of translation of messenger RNA. In all eukaryotic organisms, genetic material is stored in the cell nucleus in the form of DNA. In order to be used, this DNA is first transcribed into messenger RNA in the cell cytoplasm, then translated into protein with the help of ribosomes, small machines capable of decoding messenger RNA to synthesise the appropriate proteins.

Health - Psychology - 27.08.2021
Maternal voice reduces pain in premature babies
Maternal voice reduces pain in premature babies
A team from the University of Geneva shows that the maternal voice reduces signs of pain in premature babies when they undergo life-saving medical interventions. A baby born prematurely often has to be separated from its parents and placed in an incubator in intensive care. For several weeks, he or she will undergo routine medical procedures that can be painful, without being relieved by too many pharmaceutical painkillers, which are risky for his or her development.

Health - Mathematics - 26.08.2021
Improving contact-tracing apps in the COVID-19 era
Improving contact-tracing apps in the COVID-19 era
An international collaboration with EPFL has developed a method to improve the performance of COVID-19 contact-tracing apps by taking into account a user's recent contacts, risk levels and shared information about tests and symptoms. Contact-tracing apps like SwissCovid have enormous potential to mitigateáthe spread of the COVID-19 pandemic.

Health - 24.08.2021
Viruses leave traces for long after infection
Viruses leave traces for long after infection
Viruses do not always kill the cells they infect. Researchers at the University of Basel have discovered in experiments with mice that cells have the power to self-heal and eliminate viruses. However, these cells undergo long-term changes. The findings may provide a hint as to why cured hepatitis C patients are more susceptible to liver cancer for years after.

Life Sciences - Health - 23.08.2021
Understanding how elephants use their trunk
Understanding how elephants use their trunk
A multidisciplinary team of scientists from the UNIGE identified how elephants evolved strategies that reduce the biomechanical complexity of their trunk. The elephant proboscis (trunk) exhibits an extraordinary kinematic versatility as it can manipulate a single blade of grass but also carry loads up to 270 kilograms.

Life Sciences - Health - 19.08.2021
Creation of a detailed 'catalogue' of degradation products in cells
Creation of a detailed ’catalogue’ of degradation products in cells
Cells have their own quality control to prevent the production and accumulation of harmful proteins. This quality control is essential for correct embryonic development in all mammals and plays an important role in tumors and genetic diseases such as cystic fibrosis. A group of researchers from the University of Bern and the University of Basel have now made visible and cataloged for the first time, "blueprints" that give rise to defective proteins and are normally recognized and rapidly degraded in cells.

Materials Science - Health - 19.08.2021
Band-aid for internal wounds
Band-aid for internal wounds
Closing wounds in the digestive tract is a challenge. researchers have now developed a polymer patch for the intestine that can be used to stably bond and seal internal injuries. A burst appendix or a life-threatening intestinal volvulus are emergencies that need to be treated by surgeons immediately.

Health - 17.08.2021
Cholesterol disrupts lipid metabolism in the cell
Cholesterol disrupts lipid metabolism in the cell
The cell's cholesterol level is decisive for fat regulation and therefore for the lipid metabolism of the entire organism. This has now been demonstrated by a research team at the University of Basel. The team discovered that a specific receptor controls the cholesterol level in the cell and thus the organismal fat metabolism.

Health - Pharmacology - 16.08.2021
Lung cancer: Hope for increasing immunotherapy efficacy
Lung cancer: Hope for increasing immunotherapy efficacy
A "paradox and setback" forced scientists to dig deeper when seeking a means to boost the power of immunotherapy in lung cancer. Understanding the problem - and finding the solution - has led to a promising potential therapy for some patients. Lung cancer is the leading cause of cancer-related death.

Pharmacology - Health - 12.08.2021
New database could accelerate drug repurposing for various diseases
New database could accelerate drug repurposing for various diseases
NICEdrug.ch, a new database developed by a group of researchers from EPFL, may help scientists assess potential drugs more quickly, including how they are metabolized by the body and their potential side effects. Researchers from EPFL have created a new open-access database of information on drug candidates and how they are metabolized by the body, which could help speed up the repurposing of old drugs as new treatments.

Sport - Health - 09.08.2021
Getting oxygenated blood to exercising muscles
Getting oxygenated blood to exercising muscles
ETH Zurich Professor Katrien De Bock and her team have discovered a certain type of blood vessel cell in muscles that multiplies rapidly upon exercise, thereby forming new blood vessels. Researchers can use this to find novel therapies for vascular disorders of the muscle. "In industrialised countries, the leading cause of surgeons having to amputate a foot or leg is impaired vascular supply to the muscles of diabetic patients," Katrien De Bock says.

Health - Life Sciences - 04.08.2021
Bacteria navigate on surfaces using a 'sense of touch'
Bacteria navigate on surfaces using a ’sense of touch’
Researchers have characterized a mechanism that allows bacteria to direct their movement in response to the mechanical properties of the surfaces the microbes move on - a finding that could help fight certain pathogens. Many disease-causing bacteria such as Pseudomonasaeruginosa crawl on surfaces through a walk-like motility known as "twitching".

Health - Pharmacology - 03.08.2021
Breath test to determine correct treatment for epilepsy
Breath test to determine correct treatment for epilepsy
Breath instead of blood: researchers from the University of Basel have developed a new test method to measure treatment success in epilepsy patients. They hope that this will enable doctors to react more precisely when treating the disease. Epilepsy affects some 50 million people worldwide and pharmaceutical treatment of the disease is a tightrope walk, as the dose must be tailored precisely to the individual patient: "Slightly too little and it isn't effective.

Health - Life Sciences - 02.08.2021
AI reveals how glucose helps the SARS-CoV-2 virus
AI reveals how glucose helps the SARS-CoV-2 virus
Why do some people get sick and die from COVID-19 while others seem to be completely unaffected? EPFL's Blue Brain Project deployed its powerful brain simulation technology and expertise in cellular and molecular biology to try and answer this question. A group in the Blue Brain assembled an AI tool that could read hundreds of thousands of scientific papers, extract the knowledge and assemble the answer - A machine-generated view of the role of blood glucose levels in the severity of COVID-19 was published today by Frontiers in Public Health, Clinical Diabetes.

Life Sciences - Health - 29.07.2021
Molecular atlas reveals how brain cells develop
Using a combination of powerful sequencing techniques and mathematical methods, researchers have traced the genetic programs that direct the development of each cell in the brain. This molecular map could help researchers to understand how the brain develops and provide insights into a range of conditions, including brain tumors and neurodevelopmental disorders.
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