A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity


Marlen Knobloch, Gregor-Alexan der Pilz, Bart Ghesquière, Werner J. Kovacs, Thomas Wegleiter, Darcie L. Moore, Martina Hruzova, Nicola Zamboni, Peter Carmeliet and Sebastian Jessberger


Controlled balance between proliferation and quiescence of neural stem/ progenitor cells (NSPCs) is required for lifelong neurogenesis. Knobloch et al. identify a metabolic shift in fatty acid oxidation (FAO) that governs the proliferation of NSPCs. Further, their data suggest an instructive role for FAO in regulating NSPC activity. Thus, Knobloch et al. identify FAO as a key metabolic pathway to regulate NSPC activity.

Highlights :
- A metabolic shift defines NSPC quiescence versus proliferation
- Quiescent NSPCs require high levels of FAO
- Changing levels of a single mtabolite is sufficient to induce NSPC proliferation

Correspondence: marlen.knobloch [at] unil (p) ch (M.K.), jessberger [at] hifo.uzh (p) ch (S.J.) http://dx.doi.org/10.1016/ j.celrep.2017.08.029