"Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures"

The contributions of neuronal and non neuronal populations in cerebral functions are increasingly studied, but a robust and stress-limited method for cell type-specific isolation is lacking.

Merienne et al. optimize a laser-capture microdissection approach and characterize transcriptomic and epigenetic mechanisms in normal or pathological mouse and human Huntington’s disease (HD) brains