Research management - Sep 28
State Secretary Hirayama in Japan for a working visit and the inauguration of a new Swissnex location
State Secretary Hirayama in Japan for a working visit and the inauguration of a new Swissnex location
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Life Sciences - Event - 28.09.2023
Economics - Life Sciences - 20.09.2023
Life Sciences - 04.07.2023
Life Sciences - Health - 30.06.2023
Life Sciences - Health - 27.06.2023 
Molecular ’hub’ regulates gene-silencing proteins
To keep their vital functions in balance, many organisms use small snippets of RNA to 'silence' messenger RNAs that code for certain proteins. New research from FMI scientists revealed a molecular hub that integrates the activities of different protein complexes involved in such RNA silencing. The findings provide insights into a key mechanism that helps to coordinate cellular functions.
Event - Health - 13.06.2023
Life Sciences - Health - 25.04.2023 
The double-helix 70 years on: five FMI studies that helped decipher the DNA
On April 25, 1953 an iconic research paper was published in the journal Nature: the description of the double-helix structure of the DNA, by James Watson and Francis Crick. Their study revolutionized the field of molecular biology and laid the foundation for modern genetics and genomics. Seventy years later, there remains a lot to discover about the "molecule of life" and scientists at the FMI are at the forefront of such research.
Life Sciences - Career - 13.02.2023
Research Management - Career - 08.02.2023
Event - 30.01.2023
Life Sciences - Campus - 18.01.2023
Life Sciences - 13.12.2022 
Time to part: how to produce sex cells with the right number of chromosomes
FMI researchers have honed in on a key process that happens when yeast cells divide to form gametes, which are the equivalents of human sperm and egg.
Life Sciences - Physics - 05.12.2022 
Mighty proteins keep DNA regions close for longer
New work by FMI researchers shows that key proteins help to stabilize the interaction between otherwise highly dynamic DNA structures.
Career - 25.10.2022
Life Sciences - Event - 26.09.2022
Life Sciences - 08.08.2022
Career - 21.07.2022
Life Sciences - Chemistry - 29.06.2022 
Watching how cells deal with stress
FMI researchers developed an imaging approach that allowed them to visualize individual molecules involved in the cell's response to stress. When a cell is exposed to stressors such as toxins, it switches on pathways aimed at repairing damage. One of these pathways is called the 'unfolded protein response', which senses unfolded or misfolded proteins in the endoplasmic reticulum — a cell organelle designated for folding proteins destined to other organelles or to be secreted by the cell.
Chemistry - Event - 24.06.2022
Research Management - Life Sciences - 20.06.2022
Life Sciences - Health - 13.06.2022
Life Sciences - 15.05.2022
Life Sciences - Health - 26.04.2022
Life Sciences - Health - 03.03.2022
Pharmacology - Health - 16.02.2022
Health - Life Sciences - 04.02.2022
Life Sciences - Health - 27.01.2022
Life Sciences - 23.12.2021
Life Sciences - Chemistry - 24.11.2021
Life Sciences - Career - 19.11.2021
Career - Event - 16.11.2021
Life Sciences - Event - 05.11.2021
Life Sciences - Health - 01.11.2021
Health - Life Sciences - 27.10.2021 
Research grant for Silvia Arber to investigate Parkinson’s
Silvia Arber - group leader at the FMI and at the Biozentrum, University of Basel - and a team of international experts receive 8 million Swiss Francs from the Aligning Science Across Parkinson's (ASAP) initiative to investigate Parkinson's.
Event - Computer Science - 29.08.2021
Health - 16.08.2021
Life Sciences - 06.07.2021
Campus - 07.06.2021
Life Sciences - Psychology - 26.05.2021 
’Tug of war’ between neurons tells the brain when to fear — and when not to be afraid
Fear protects us by making us alert to danger, but the persistence of fearful memories can lead to serious mental conditions. Now, an international team of researchers co-led by Andreas Lüthi has found that the activity of different cells in the brain's threat-detector hub regulates the switch between high and low fear states.
Life Sciences - Campus - 05.05.2021
Life Sciences - 28.04.2021
Life Sciences - Research Management - 22.04.2021
Life Sciences - Career - 06.04.2021
Life Sciences - 17.03.2021
Life Sciences - 16.02.2021
Health - Life Sciences - 01.02.2021 
A key regulator for humoral immunity and B lymphoma
The generation of antibodies in B-cells takes place in a dynamic structure that forms during infections, the germinal center (GC).
Career - 28.01.2021
Event - Life Sciences - 25.01.2021
Career - Life Sciences - 07.12.2020
Life Sciences - Computer Science - 02.11.2020 
Building artificial neural networks inspired by the brain
The requirements of real biological neural networks are modest compared to the complex deep neural networks used in machine learning, which come with substantial memory and energy demands. The Zenke group have developed a new method in machine learning called Neural Tangent Transfer to make a sparse neural network which performs almost as well as densely connected deep neural network on various learning tasks, but at a heavily reduced computing cost.
Friedrich Miescher Institute for Biomedical Research
Results 1 - 50 of 144.
From postdoc to entrepreneur
After a 1.5-year postdoc in the Liberali lab — where he co-developed and tested a new microscope to track the development of organoids in real time — Andrea Boni co-founded a company that provides live-imaging systems based on a revolutionary microscopy technology.
After a 1.5-year postdoc in the Liberali lab — where he co-developed and tested a new microscope to track the development of organoids in real time — Andrea Boni co-founded a company that provides live-imaging systems based on a revolutionary microscopy technology.
Zeroing in on how the ’guardian of the genome’ works
The tumor suppressor protein p53 has been dubbed the 'guardian of the genome' because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI researchers have homed in on some of the mechanisms that regulate the activation of p53 target genes.
The tumor suppressor protein p53 has been dubbed the 'guardian of the genome' because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI researchers have homed in on some of the mechanisms that regulate the activation of p53 target genes.
To keep their vital functions in balance, many organisms use small snippets of RNA to 'silence' messenger RNAs that code for certain proteins. New research from FMI scientists revealed a molecular hub that integrates the activities of different protein complexes involved in such RNA silencing. The findings provide insights into a key mechanism that helps to coordinate cellular functions.
On April 25, 1953 an iconic research paper was published in the journal Nature: the description of the double-helix structure of the DNA, by James Watson and Francis Crick. Their study revolutionized the field of molecular biology and laid the foundation for modern genetics and genomics. Seventy years later, there remains a lot to discover about the "molecule of life" and scientists at the FMI are at the forefront of such research.
Congratulations to our 2022 fellows
FMI researchers are awarded competitive grants and fellowship throughout the year, which speaks for the quality and potential of their work.
FMI researchers are awarded competitive grants and fellowship throughout the year, which speaks for the quality and potential of their work.
Becoming a lab head
In this new series, we feature FMI alumni and the diverse careers they have chosen after leaving our institute.
In this new series, we feature FMI alumni and the diverse careers they have chosen after leaving our institute.
FMI researchers have honed in on a key process that happens when yeast cells divide to form gametes, which are the equivalents of human sperm and egg.
New work by FMI researchers shows that key proteins help to stabilize the interaction between otherwise highly dynamic DNA structures.
FMI science prizes - winners 2022
The three FMI internal science prizes are awarded yearly and recognize respectively the best thesis, the best postdoc study and an ingenious new method or tool.
The three FMI internal science prizes are awarded yearly and recognize respectively the best thesis, the best postdoc study and an ingenious new method or tool.
FMI researchers developed an imaging approach that allowed them to visualize individual molecules involved in the cell's response to stress. When a cell is exposed to stressors such as toxins, it switches on pathways aimed at repairing damage. One of these pathways is called the 'unfolded protein response', which senses unfolded or misfolded proteins in the endoplasmic reticulum — a cell organelle designated for folding proteins destined to other organelles or to be secreted by the cell.
Spotlight on FMIers: Iskra Katic
At first glance, Caenorhabditis elegans , or C. elegans for short, isn't exactly awe-inspiring.
At first glance, Caenorhabditis elegans , or C. elegans for short, isn't exactly awe-inspiring.
Spotlight on FMIers: Gisèle Ferrand
To discover the molecular mechanisms of health and disease, some FMI researchers use animals such as mice and fish.
To discover the molecular mechanisms of health and disease, some FMI researchers use animals such as mice and fish.
How neurons that wire together fire together
For amplifying sensory stimuli quickly and accurately, neuronal circuits require specific wiring. Some 70 years ago, the compelling idea that "neurons that fire together wire together" emerged. Yet, in computational models, neurons that wire together tend to succumb to an explosion of activity and instability not observed in neurobiology.
For amplifying sensory stimuli quickly and accurately, neuronal circuits require specific wiring. Some 70 years ago, the compelling idea that "neurons that fire together wire together" emerged. Yet, in computational models, neurons that wire together tend to succumb to an explosion of activity and instability not observed in neurobiology.
Silvia Arber - group leader at the FMI and at the Biozentrum, University of Basel - and a team of international experts receive 8 million Swiss Francs from the Aligning Science Across Parkinson's (ASAP) initiative to investigate Parkinson's.
Fear protects us by making us alert to danger, but the persistence of fearful memories can lead to serious mental conditions. Now, an international team of researchers co-led by Andreas Lüthi has found that the activity of different cells in the brain's threat-detector hub regulates the switch between high and low fear states.
FMI: Congratulations to our fellowship winners
April 6, 2021 We are pleased to announce the latest FMI winners of prestigious research fellowships, including EMBO, Maria Sklodowska-Curie Actions (MSCA), Human Frontier Science Program (HFSP) and Boehringer Ingelheim Funds (BIF).
April 6, 2021 We are pleased to announce the latest FMI winners of prestigious research fellowships, including EMBO, Maria Sklodowska-Curie Actions (MSCA), Human Frontier Science Program (HFSP) and Boehringer Ingelheim Funds (BIF).
Extensive remodeling of chromatin after DNA damage
In eukaryotes, histones are often modified and evicted at site of DNA double-strand breaks in order to facilitate end-resection and break repair. Together with the protein analysis facility of the FMI, the Gasser group has quantified massive changes in the chromatin associated proteome in response to DNA damage.
In eukaryotes, histones are often modified and evicted at site of DNA double-strand breaks in order to facilitate end-resection and break repair. Together with the protein analysis facility of the FMI, the Gasser group has quantified massive changes in the chromatin associated proteome in response to DNA damage.
The generation of antibodies in B-cells takes place in a dynamic structure that forms during infections, the germinal center (GC).
The requirements of real biological neural networks are modest compared to the complex deep neural networks used in machine learning, which come with substantial memory and energy demands. The Zenke group have developed a new method in machine learning called Neural Tangent Transfer to make a sparse neural network which performs almost as well as densely connected deep neural network on various learning tasks, but at a heavily reduced computing cost.
Research management - Sep 28
State Secretary Hirayama in Japan for a working visit and the inauguration of a new Swissnex location
State Secretary Hirayama in Japan for a working visit and the inauguration of a new Swissnex location