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Friedrich Miescher Institute for Biomedical Research


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Life Sciences - Event - 26.09.2022
FMI science prizes - winners 2022
The three FMI internal science prizes are awarded yearly and recognize respectively the best thesis, the best postdoc study and an ingenious new method or tool.

Life Sciences - Chemistry - 29.06.2022
Watching how cells deal with stress
Watching how cells deal with stress
FMI researchers developed an imaging approach that allowed them to visualize individual molecules involved in the cell's response to stress. When a cell is exposed to stressors such as toxins, it switches on pathways aimed at repairing damage. One of these pathways is called the 'unfolded protein response', which senses unfolded or misfolded proteins in the endoplasmic reticulum — a cell organelle designated for folding proteins destined to other organelles or to be secreted by the cell.

Chemistry - Event - 24.06.2022

Research Management - Life Sciences - 20.06.2022

Life Sciences - Health - 13.06.2022
Spotlight on FMIers: Iskra Katic
At first glance, Caenorhabditis elegans , or C. elegans for short, isn't exactly awe-inspiring.

Life Sciences - 15.05.2022

Life Sciences - Health - 26.04.2022

Life Sciences - Health - 03.03.2022

Health - Life Sciences - 04.02.2022
Spotlight on FMIers: Gisèle Ferrand
To discover the molecular mechanisms of health and disease, some FMI researchers use animals such as mice and fish.

Life Sciences - Health - 27.01.2022

Life Sciences - 23.12.2021
How neurons that wire together fire together
For amplifying sensory stimuli quickly and accurately, neuronal circuits require specific wiring. Some 70 years ago, the compelling idea that "neurons that fire together wire together" emerged. Yet, in computational models, neurons that wire together tend to succumb to an explosion of activity and instability not observed in neurobiology.

Life Sciences - Career - 19.11.2021

Life Sciences - Health - 01.11.2021

Health - Life Sciences - 27.10.2021
Research grant for Silvia Arber to investigate Parkinson's
Research grant for Silvia Arber to investigate Parkinson’s
Silvia Arber - group leader at the FMI and at the Biozentrum, University of Basel - and a team of international experts receive 8 million Swiss Francs from the Aligning Science Across Parkinson's (ASAP) initiative to investigate Parkinson's.

Event - Computer Science - 29.08.2021

Life Sciences - Psychology - 26.05.2021
'Tug of war' between neurons tells the brain when to fear — and when not to be afraid
’Tug of war’ between neurons tells the brain when to fear — and when not to be afraid
Fear protects us by making us alert to danger, but the persistence of fearful memories can lead to serious mental conditions. Now, an international team of researchers co-led by Andreas Lüthi has found that the activity of different cells in the brain's threat-detector hub regulates the switch between high and low fear states.

Life Sciences - Campus - 05.05.2021

Life Sciences - 28.04.2021

Life Sciences - Research Management - 22.04.2021

Life Sciences - Career - 06.04.2021
FMI: Congratulations to our fellowship winners
April 6, 2021 We are pleased to announce the latest FMI winners of prestigious research fellowships, including EMBO, Maria Sklodowska-Curie Actions (MSCA), Human Frontier Science Program (HFSP) and Boehringer Ingelheim Funds (BIF).

Life Sciences - 17.03.2021

Life Sciences - 16.02.2021
Extensive remodeling of chromatin after DNA damage
In eukaryotes, histones are often modified and evicted at site of DNA double-strand breaks in order to facilitate end-resection and break repair. Together with the protein analysis facility of the FMI, the Gasser group has quantified massive changes in the chromatin associated proteome in response to DNA damage.

Health - Life Sciences - 01.02.2021
A key regulator for humoral immunity and B lymphoma
A key regulator for humoral immunity and B lymphoma
The generation of antibodies in B-cells takes place in a dynamic structure that forms during infections, the germinal center (GC).

Career - Life Sciences - 07.12.2020

Life Sciences - Computer Science - 02.11.2020
Building artificial neural networks inspired by the brain
Building artificial neural networks inspired by the brain
The requirements of real biological neural networks are modest compared to the complex deep neural networks used in machine learning, which come with substantial memory and energy demands. The Zenke group have developed a new method in machine learning called Neural Tangent Transfer to make a sparse neural network which performs almost as well as densely connected deep neural network on various learning tasks, but at a heavily reduced computing cost.

Life Sciences - 21.10.2020
How the visual cortex combines movement and vision
How the visual cortex combines movement and vision
The Keller group had previously shown that the coupling of sensory and motor experience was critical for normal sensorimotor processing. The researchers have now identified the particular subset of cortical neurons responsible for computing mismatches between what we expect to see based on movement and what we actually see, and are likely essential for helping us distinguish between self-generated and externally generated sensations.

Life Sciences - Chemistry - 21.09.2020
How to make a replication origin in multicellular eukaryotes
How to make a replication origin in multicellular eukaryotes
Loading of replicative helicases onto DNA is a key event during the initiation of chromosomal DNA replication.

Health - Life Sciences - 08.09.2020
LifeTime - Researchers partner to improve European healthcare
LifeTime - Researchers partner to improve European healthcare
The FMI is a partner of the pan-European LifeTime initiative. In two publications, researchers involved with the initiative - including FMI group leader Susan Gasser - present a detailed roadmap of how to leverage the latest scientific breakthroughs and technologies over the next decade, to track, understand and treat human cells throughout an individual's lifetime.

Life Sciences - Health - 07.09.2020
How to identify new molecular glue degraders
How to identify new molecular glue degraders
Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, tagging the target protein for degradation.

Research Management - Career - 03.09.2020

Life Sciences - Chemistry - 31.08.2020
FMI is a partner in the new EU
FMI is a partner in the new EU “HCA|Organoid” project
Organoid" was launched today. It aims at validating organoids as faithful models of human biology, combining single-cell profiling and organoid technology.

Life Sciences - 11.06.2020
How transcription factors recognize binding motifs on chromatin
How transcription factors recognize binding motifs on chromatin
In a video (5'35'') combining interviews and figures, the team behind the latest collaboration from the Thomä and Schübeler labs - Alicia Michael, Ralph Grand and Luke Isbel - explain how they developed an assay identifying where the preferable sites for the transcription factor-DNA binding motif on the nucleosome were, so that they could build transcription factor-nucleosome complexes.

Life Sciences - Health - 08.04.2020
The Friedrich Miescher Institute for Biomedical Research turns 50
The Friedrich Miescher Institute for Biomedical Research turns 50
April 8, 2020 On April 8, 1970, the founding charter of the FMI was signed. For 50 years, the FMI has stayed true to its initial mission: To promote basic research in the fields of biochemistry and medicine, and to train young scientists.

Life Sciences - 05.04.2020
The circuitous path to adulthood
The circuitous path to adulthood
Genes that time the transition to adulthood are well-studied in the roundworm C. elegans, and at least partially conserved in mammals, where they regulate the onset of puberty.
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