Novartis strengthens Oncology pipeline with successful closing of tislelizumab in-licensing

  • Adds tislelizumab, a uniquely designed anti-PD-1 monoclonal antibody for monotherapy and proprietary combination cancer therapies with Novartis portfolio and pipeline therapies
  • Novartis will co-develop tislelizumab with BeiGene and expand access to patients in North America, Europe and Japan

  • Specifically designed to minimize binding to Fc’R on macrophages, tislelizumab will be key asset in Novartis immuno-oncology combination strategy

Basel, February 26, 2021 - Novartis today announced that it has closed the in-licensing of tislelizumab from BeiGene, Ltd. in North America, Europe and Japan. Tislelizumab is a uniquely designed anti-PD-1 antibody, specifically engineered to minimize binding to FcyR on macrophages, that is approved in China for certain patients with non-small cell lung cancer, classical Hodgkin’s lymphoma and metastatic urothelial carcinoma.

"We are very excited about the recent positive results from BeiGene’s global trials of tislelizumab in non-small cell lung cancer and esophageal squamous cell carcinoma and the opportunity to discuss these data with health authorities," said Susanne Schaffert, PhD, President, Novartis Oncology. "We look forward to collaborating with BeiGene to initiate additional global clinical trials of tislelizumab in combination with Novartis Oncology therapies to fully tap the potential of this uniquely designed anti PD-1, and ultimately enable access to tislelizumab to people living with cancer."

Novartis has identified multiple opportunities to combine tislelizumab with other therapies in the Novartis portfolio and pipeline. Tislelizumab is currently being studied in non-small cell lung cancer, gastric cancer, hepatocellular carcinoma and nasopharyngeal carcinoma, with broad potential in several other solid tumors.