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Results 1451 - 1500 of 1666.

Health - Pharmacology - 19.04.2012
Novartis announces Aliskiren will continue to be available to appropriate patients, as FDA interim assessment is concluded; product information updated
Combination product Valturna to be voluntarily withdrawn from the US market as of July 20, 2012 Basel, Switzerland April 19, 2012 - Novartis announced today that the Tekturna labels have been updated

Pharmacology - Health - 19.04.2012
New extension study data with Novartis drug Gilenya shows patients successfully treated for up to 7 years in relapsing MS
Results from open label phase III extension and 7-year phase II extension studies show sustained low disease activity on clinical and MRI measures in patients continuing on Gilenya (fingolimod) treatment Extension study results demonstrate a safety profile for Gilenya consistent with pivotal trials Data from FIRST study in more than 2,400 patients show overall low incidence of first dose bradycardia and conduction abnormalities at treatment init

Chemistry - Pharmacology - 17.04.2012
EPFL de doctorate award 2012 - Oleg Vechorkin
EPFL de doctorate award 2012 - Oleg Vechorkin
A Well-Defined Ni Pincer Catalyst for Cross Coupling of Non-Activated Alkyl Halides and Direct C-H Alkylation.

Economics / Business - Pharmacology - 06.04.2012
Roche disappointed with ISS recommendation
Roche disappointed with ISS recommendation Urges Illumina shareholders to vote the GOLD proxy card Roche released the following statement in response to a report issued by Institutional Shareholder Services ("ISS") recommending that shareholders of Illumina, Inc.

Health - Pharmacology - 02.04.2012
Novartis QVA149 Phase III COPD studies meet primary endpoints
QVA149, a bronchodilator with dual mode of action, is Novartis' third innovation in its Breezhaler Single Dose Dry Powder Inhaler COPD is predicted to be the third leading cause of death in the world

Health - Pharmacology - 28.03.2012
Novartis launches the Cancer Cell Line Encyclopedia (CCLE) to catalogue world’s cancer cell lines
Collaboration with the Broad Institute yields comprehensive encyclopedia of genetic and molecular information for nearly 1,000 cancer cell lines Basel, March 28, 2012 - Novartis and the Broad Institute have developed a cancer cell line encyclopedia that catalogues the genetic and molecular profiles of almost 1,000 human cancer cell lines used in drug research and development.

Health - Pharmacology - 27.03.2012
Study in JAMA reports significant survival benefit in certain GIST patients taking Novartis drug Glivec for three years after surgery
First large Phase III study to demonstrate significant survival benefits of extending treatment with Glivec for three years compare d to one year following surgery Important finding for treatment of KIT+ GIST patients who are at risk of recurrence following complete resection of primary tumor Basel, March 27, 2012 - The Journal of the American Medical Association (JAMA) today published a Phase III study that showed significant survival benefits

Health - Pharmacology - 16.03.2012
Alcon gains exclusive ex-US rights for ocriplasmin, potential first pharmacological treatment for symptomatic vitreomacular adhesion
Symptomatic vitreomacular adhesion (VMA) is a progressive, debilitating eye disease, there is currently no pharmacological treatment available Phase III clinical data demonstrate resolution of sympto

Health - Pharmacology - 07.03.2012
Data in NEJM shows Novartis drug Signifor is first therapy to provide rapid, durable benefit for Cushing’s disease patients in Phase III study
Study met primary endpoint showing Signifor (pasireotide) normalized cortisol overproduction , a critical factor in controlling the debilitating endocrine disorder , , Cortisol levels decreased quickly in the majority of patients and levels were normalized in 26.3% of patients treated with pasireotide 900g twice daily Results showed pasireotide improved key clinical manifestations of the disease, including reductions in blood pressure, c

Health - Pharmacology - 02.03.2012
Reprogramming tumor-promoting macrophages for anti-cancer therapy
Reprogramming tumor-promoting macrophages for anti-cancer therapy
Researchers who have recently established their laboratory at the EPFL School of Life Sciences have identified a small RNA molecule that limits the pro-tumoral functions of macrophages.

Pharmacology - Health - 29.02.2012
Two Phase III studies of Novartis drug INC424 published in NEJM show significant clinical benefit for patients with myelofibrosis
Results of the COMFORT-I and COMFORT-II trials show INC424 significantly reduced disease burden in patients with myelofibrosis Myelofibrosis is a life-threatening blood cancer associated with progressive, debilitating symptoms that severely impact quality of life and reduce survival These data provided the basis for worldwide regulatory filings with first actions expected in the second half of 2012 Basel, February 29, 2012 - The New England Jour

Health - Pharmacology - 27.02.2012
European Commission approves new label for Novartis drug Glivec
Approval based on Phase III study showing significant recurrence-free and overall survival after three years of adjuvant Glivec in adults with KIT+ GIST Adults with KIT+ GIST are at risk of recurrence following surgical removal of the primary tumor; extended treatment may delay onset of recurrence Basel, February 27, 2012 - Novartis announced today that the European Commission (EC) has approved an update to the Glivec (imatinib)* label to includ

Health - Pharmacology - 24.02.2012
Breaking Down Cancer's Defense for Future Vaccines
Breaking Down Cancer's Defense for Future Vaccines
Researchers at the EPFL have identified an important mechanism that could lead to the design of more effective cancer vaccines. Their discovery of a new-found role of the lymphatic system in tumour growth shows how tumours evade detection. Tumour cells present antigens or protein markers on their surfaces which make them identifiable to the host immune system.

Pharmacology - Health - 17.02.2012
Novartis to revise product information in the European Union for high blood pressure drug Rasilez following assessment by CHMP
CHMP concluded the risk-benefit review of Rasilez* (aliskiren) and confirmed it remains positive for the treatment of essential hypertension CHMP has requested that the Rasilez (aliskiren) product in

Pharmacology - Health - 13.02.2012
New immunotherapeutic agent for the treatment of Alzheimer's disease
New immunotherapeutic agent for the treatment of Alzheimer's disease
Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides.

Pharmacology - Health - 13.02.2012
FDA requests additional data on Novartis
Basel, February 13, 2012 - Novartis has received a Complete Response letter from the US Food and Drug Administration (FDA) on its application for the expanded use of Menveo (Meningococcal [Groups A,

Health - Pharmacology - 07.02.2012
Pivotal study published in JAMA confirms potential of Novartis candidate vaccine Bexsero to help protect infants against devastating meningococcal serogroup B disease
Data previously presented at ESPID annual meeting add to the body of evidence showing that Bexsero can help protect all vulnerable age groups Study including more than 1,800 infants showed Bexsero induces robust immune response when given alone or with other routine vaccines in different vaccination schedules Current vaccines do not broadly protect against MenB which is easily misdiagnosed and can kill within 24 hours; infants are at highest ris

Health - Pharmacology - 01.02.2012
FDA approves Novartis drug Glivec label recommending extending treatment to three years for certain GIST patients after surgery
Phase III results showed 54% reduction in risk of recurrence and 55% reduction in risk of death after three years' adjuvant Glivec in adults with KIT+ GIST Approval builds on vast experience with Glivec, first approved 10 years ago for treatment of adults with metastatic and/or unresectable KIT+ GIST Basel, February 1, 2012 - Novartis announced today that following a priority review, the US Food and Drug Administration (FDA) has approved an upda

Health - Pharmacology - 30.01.2012
Novartis extends commitment to help achieve final elimination of leprosy
New five-year commitment includes donation of treatments worth an estimated USD 22.5 million and is expected to reach an estimated 850,000 patients Novartis will also intensify efforts to buil

Health - Pharmacology - 25.01.2012
Novartis delivers strong underlying financial performance in 2011, expects 2012 sales to be in line with 2011
Fourth quarter sales rose 5% while core operating income grew 17% in constant currencies (cc); full year sales up 12% cc and core operating income up 16% cc Core operating income grew 12% (+17% cc) t

Health - Pharmacology - 20.01.2012
CHMP recommends EU approval to update Novartis drug Glivec label to include three year treatment for GIST patients after surgery
Opinion based on Phase III study showing 66% recurrence-free and 92% overall survival at five years after three years' adjuvant Glivec in adults with KIT+ GIST Glivec has helped transform treatment and outcomes in patients with KIT+ GIST since its first approval in the metastatic setting almost 10 years ago Basel, January 20, 2012 - Novartis announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines

Health - Pharmacology - 20.01.2012
Novartis drug Signifor recommended by CHMP for EU approval to treat patients with Cushing’s disease
If approved, Signifor (SOM230, pasireotide) would be the first approved medication targeting Cushing's disease In clinical trials, pasireotide suppresses overproduction of cortisol caused by an under

Pharmacology - Health - 19.01.2012
Sandoz initiates two more Phase III biosimilar trials, reinforcing long-term global leadership commitment
Phase III clinical study for filgrastim biosimilar (Neupogen ) is expected to support expansion to the US market Phase III study for Sandoz pegfilgrastim (Neulasta ) represents next major step in San

Health - Pharmacology - 18.01.2012
Novartis receives approval for Lucentis and launches Galvus in China
Lucentis (ranibizumab) approved in China to treat wet age-related macular degeneration, a major cause of blindness and severe vision loss in people over 50 Oral type 2 diabetes treatment Galvus (vild

Pharmacology - Economics / Business - 13.01.2012
Novartis to restructure US business
Novartis to restructure US business to strengthen competitive position in light of loss of Diovan patent and announces charge for Rasilez /Tekturna.

Pharmacology - Economics / Business - 08.01.2012
Novartis recalls certain over-the-counter products in the US
The recall is precautionary following consumer complaints of chipped and broken pills and inconsistent bottle packaging line clearance practices possibly resulting in mixed tablets There have been no

Health - Pharmacology - 23.12.2011
Roche medicine Avastin receives EU approval for the treatment of women with newly diagnosed, advanced ovarian cancer
Roche medicine Avastin receives EU approval for the treatment of women with newly diagnosed, advanced ovarian cancer Avastin represents first major treatment advance for women with ovarian cancer in

Health - Pharmacology - 20.12.2011
Novartis announces termination of ALTITUDE study with Rasilez / Tekturna in high-risk patients with diabetes and renal impairment
ALTITUDE study involved patients with type 2 diabetes and renal impairment who are at high risk of cardiovascular and renal events Committee overseeing study identified higher adverse events when Ras

Pharmacology - Health - 15.12.2011
Novartis drug Gilenya showed positive clinical outcomes
Once-daily oral MS medicine showed a 48% relative reduction in annualized relapse rate, meeting primary endpoint in Phase III placebo-controlled study Significant reduction in brain volume loss demonstrated, reinforcing strong efficacy benefit in key secondary endpoint Basel, December 15, 2011 - Novartis announced today new data from the Phase III 2309 study showing patients with relapsing-remitting multiple sclerosis (RRMS) treated with Gilenya (fingolimod) had a statistically significant 48% reduction in annualized relapse rates (ARR) at 24 months compared to placebo.

Pharmacology - Health - 13.12.2011
Novartis pivotal study of Exjade shows significant reduction of iron overload in patients with non-transfusion-dependent thalassemia
Trial shows Exjade, an iron chelator, is significantly better than placebo at reducing liver iron concentration in patients with NTDT Non-transfusion-dependent thalassemia (NTDT) is a genetic blood disorder in which patients may accumulate excess iron in the body Data will serve as basis for first regulatory filings in US and Europe by year end Basel, December 13, 2011 - Results from THALASSA, the first pivotal placebo-controlled study examining

Pharmacology - Health - 13.12.2011
New Phase III data shows Novartis JAK inhibitor INC424 significantly reduced disease burden in patients with myelofibrosis
COMFORT-II data showed INC424 provided clinically relevant and statistically significant improvements in symptoms at all evaluations vs.

Pharmacology - Health - 12.12.2011
Two Novartis Phase III studies show twice as many Ph+ CML patients achieve deeper levels of response with Tasigna compared to Glivec
ENESTcmr data show 23% of patients switched to Tasigna achieved undetectable levels of Bcr-Abl within 12 months compared to 11% who continued on Glivec Three-year ENESTnd data show 32% of newly diagnosed patients on Tasigna reached deepest levels of molecular response measured versus 15% on Glivec ENESTnd study also shows significantly fewer patients progressed to advanced stages of CML with Tasigna after three years, compared to Glivec Basel, D

Health - Pharmacology - 08.12.2011
New data confirms Novartis drug Afinitor significantly extends time women with advanced breast cancer live without tumor growth
Longer-term BOLERO-2 data reveal treatment with everolimus combined with hormonal therapy improved time to disease progression to 7.4 versus 3.2 months with hormonal therapy alone These results presented at SABCS provide further evidence that everolimus may represent a major advance for women with ER+HER2- breast cancer Published in NEJM today are previously-reported positive results of BOLERO-2, which serve as the basis for first

Pharmacology - 07.12.2011
INT-777 - a new drug against obesity.
INT-777 - a new drug against obesity.
TGR5 activation inhibits Atherosclerosis by reducing macrophage inflammation and lipid loading.

Health - Pharmacology - 02.12.2011
Novartis highlights advances for patients with breast cancer and hematological diseases with over 160 SABCS and ASH abstracts
Tasigna Phase III trials in Ph+ CML including 36-month follow-up data in newly diagnosed patients Exjade pivotal study results investigating iron chelation in patients with non-transfusion-dependent

Pharmacology - Health - 28.11.2011
Novartis gains European Commission approval for Rasitrio , a Rasilez-based triple combination pill to treat high blood pressure
Pivotal phase III data showed significantly greater blood pressure reductions with Rasitrio compared to dual combinations of each of its individual components Up to 85 percent of patients may need mu

Pharmacology - Health - 18.11.2011
FDA Commissioner Announces Final Decision on Avastin for Metastatic Breast Cancer
FDA Commissioner Announces Final Decision on Avastin for Metastatic Breast Cancer U.S. Food and Drug Administration (FDA) Commissioner revokes approval of Avastin for treatment of metas

Life Sciences - Pharmacology - 11.11.2011
Better muscles thanks to a genetic knock-out
A team of researchers has improved the muscle structure and stamina of mice and nematodes by reducing the function of a natural inhibitor, suggesting treatments for age-related or genetically caused muscle degeneration are within reach. If they weren't held back by the effect of a natural inhibitor, our muscles would be stronger, more powerful and better formed than they are in reality.

Health - Pharmacology - 09.11.2011
FDA accepts Roche’s New Drug Application for vismodegib in advanced form of skin cancer
FDA accepts Roche's New Drug Application for vismodegib in advanced form of skin cancer The vismodegib application has been granted priority review Roche today announced that the U.S. F

Health - Pharmacology - 07.11.2011
Novartis Phase III study of ACZ885
Novartis Phase III study shows ACZ885 helped substantially reduce steroid use in 45% of patients with serious form of childhood arthritis Chronic steroid use to treat the symptoms of systemic juvenil

Health - Pharmacology - 05.11.2011
Novartis DEB025 data showed viral clearance as early as six weeks and potential for interferon-free therapy in hepatitis C patients
Phase II data showed oral once daily DEB025 plus ribavirin provided viral clearance in almost half of genotype 2 and 3 patients with hepatitis C DEB025 targets host proteins required for hepatitis C virus replication, showing activity across genotypes and high barrier to resistance More than 170 million people worldwide suffer from hepatitis C, a serious liver disease that can lead to cirrhosis, liver cancer and in some cases death Basel, Novemb

Health - Pharmacology - 24.10.2011
Relief of symptoms in up to 81% of patients with psoriasis
Novartis Phase II data show AIN457 provided rapid and significant relief of symptoms in up to 81% of patients with psoriasis In three Phase II trials, AIN457 provided a substantial increase in skin clearance in patients with moderate-to-severe plaque psoriasis[1-3] AIN457, a fully human anti-IL17A monoclonal antibody, offers a novel mechanism of action that suppresses the underlying inflammation in psoriasis[1-3] Approximately 2% of the world's

Pharmacology - Health - 17.10.2011
Novartis drug Gilenya
Novartis drug Gilenya (fingolimod) has more than 20,000 patient-years of exposure and shows up to 71% reduction in annualized relapse rates in MS patients with highly active disease Analyses presented at 5 th Joint Triennial Congress of ECTRIMS and ACTRIMS showed relapse rate reductions were consistent among subgroups of fingolimod-treated patients that had highly active disease in pivotal clinical trials Fingolimod demonstrated reductions in ra

Pharmacology - Health - 27.09.2011
New Novartis data show potential of respiratory portfolio to help COPD patients maintain active and productive lives
Studies show investigational once-daily NVA237 provides superior 24-hour bronchodilation and increases exercise endurance relative to placebo , Additional data show NVA237 significantly prolonged time to first moderate/ severe COPD exacerbation and reduced associated hospitalizations NVA237 submitted for EU approval under brand-name Seebri Breezhaler for treatment of chronic obstructive pulmonary disease (COPD) Basel , September 27, 2011 - Novar

Pharmacology - Health - 27.09.2011
Novartis receives approval in Japan for two innovative therapies, Gilenya in MS and Ilaris in CAPS
Gilenya first high efficacy oral therapy approved in Japan for the prevention of relapse and delay of progression of physical disability in adults with multiple sclerosis (MS) Ilaris the first drug a

Health - Pharmacology - 26.09.2011
Novartis drug Afinitor helps women with advanced breast cancer live significantly longer without their disease progressing
Everolimus combined with hormonal therapy more than doubled time without tumor growth and reduced risk of progression by 57% vs hormonal therapy alone Study shows everolimus significantly enhances benefit from hormonal therapy, representing important advance for women with postmenopausal ER+ breast cancer , Worldwide regulatory filings planned by the end of 2011 based on these data, marking the first submission for everolimus in breast cancer Ba

Health - Pharmacology - 25.09.2011
QTI571 significantly improved walking distance in patients with life-threatening pulmonary arterial hypertension
Phase III IMPRES study demonstrates potential benefits of QTI571 in patients who remain symptomatic despite treatment with two or more PAH therapies Evidence indicates that QTI571 targets an underlying cause of PAH by counteracting uncontrolled growth of arterial smooth muscle cells PAH is a debilitating disease of the heart and lungs affecting up to 260,000 people worldwide leading to heart failure and death , Basel, September 25, 2011 - Novart

Health - Pharmacology - 23.09.2011
Novartis drug Afinitor effective in patients with non-cancerous kidney tumors associated with TSC in Phase III trial
Study met primary endpoint of kidney tumor response rate with 42% of patients on everolimus experiencing a response versus 0% on placebo Kidney tumors are present in up to 80% of patients with tubero

Pharmacology - Health - 23.09.2011
Novartis gains positive CHMP opinion for Rasitrio
Rasitrio combines the only approved direct renin inhibitor, Rasilez, with the calcium channel blocker amlodipine, and the diuretic hydrochlorothiazide (HCT) In Phase III data, Rasitrio demonstrated s