Roche to present new data at AAN reinforcing efficacy and safety of newly FDA-approved OCREVUS? (ocrelizumab) in two types of multiple sclerosis

19 April 2017   »   English      

Roche to present new data at AAN reinforcing efficacy and safety of newly FDA-approved OCREVUS? (ocrelizumab) in two types of multiple sclerosis

  • Data presentations will include platform sessions and posters across relapsing multiple sclerosis and primary progressive multiple sclerosis

Roche announced today that new data on OCREVUS (ocrelizumab) in people with relapsing forms of multiple sclerosis (RMS) and primary progressive MS (PPMS) will be presented during the 69th American Academy of Neurology (AAN) Annual Meeting from 22 to 28 April in Boston, Massachusetts.

Data presented across three platform sessions will describe the rapid benefit of OCREVUS in RMS patients in the first eight weeks of treatment and its effect on fatigue in PPMS patients. Efficacy and safety data from the open-label extension study will also be presented, as well as the effect of OCREVUS on active disease and progression in PPMS.

“OCREVUS is the only disease-modifying therapy approved by the FDA for people with primary progressive MS and offers people with relapsing MS a new treatment option with a favourable benefit-risk profile”, said Sandra Horning, MD, Roche’s Chief Medical Officer and Head of Global Product Development. “The data being presented at AAN will demonstrate how rapidly OCREVUS controls disease activity and reduces brain MRI lesions in people with early RMS, both of which are important goals of treatment.’’

Leading investigators will present the following oral and poster presentations:

Full session details and data presentation listings for the 2017 AAN Annual Meeting can be found at the meeting website: www.aan.com/conferen­ces/2017-annual-meeting/

OCREVUS received approval from the U.S. Food and Drug Administration (FDA) on 28 March 2017 for the treatment of adult patients with relapsing or primary progressive forms of MS.

Follow Roche on Twitter via @Roche and keep up to date with AAN 2017 Annual Meeting news and updates by using the hashtag #AANAM.

About OCREVUS (ocrelizumab)

OCREVUS is a humanised monoclonal antibody designed to target CD20-positive B cells, a specific type of immune cell thought to be a key contributor to myelin (nerve cell insulation and support) and axonal (nerve cell) damage. This nerve cell damage can lead to disability in people with MS. Based on preclinical studies, OCREVUS binds to CD20 cell surface proteins expressed on certain B cells, but not on stem cells or plasma cells, and therefore important functions of the immune system may be preserved.

OCREVUS is administered by intravenous infusion every six months. The initial dose is given as two 300 mg infusions given two weeks apart. Subsequent doses are given as single 600 mg infusions.

About Roche in neuroscience

Neuroscience is a major focus of research and development at Roche. The company’s goal is to develop treatment options based on the biology of the nervous system to help improve the lives of people with chronic and potentially devastating diseases. Roche has more than a dozen investigational medicines in clinical development for diseases that include multiple sclerosis, Alzheimer’s disease, spinal muscular atrophy, Parkinson’s disease and autism.