T cells in patients with narcolepsy target self-antigens of hypocretin neurons

Latorre D., Kallweit U., Armentani E., Foglierini M., Mele F., Cassotta A., Jovic S., Jarrossay D., Mathis J., Zellini F., Becher B., Lanzavecchia A., Khatami R., Manconi M., Tafti M., Bassetti CL., Sallusto F.

Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce hypocretin. The close association with HLA-DQB1*06:02, evidence for immune dysregulation and increased incidence upon influenza vaccination together suggest that this disorder has an autoimmune origin. However, there is little evidence of autoreactive lymphocytes in patients with narcolepsy.