Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research   link
Location: Basel

Discipline: Health
Affiliation: Novartis

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - Oct 21
Life Sciences
The Keller group had previously shown that the coupling of sensory and motor experience was critical for normal sensorimotor processing. The researchers have now identified the particular subset of cortical neurons responsible for computing mismatches between what we expect to see based on movement and what we actually see, and are likely essential for helping us distinguish between self-generated and externally generated sensations.
Chemistry - Life Sciences - Oct 8
Chemistry - Life Sciences

Intestinal organoids recapitulate not only the structure of intestinal epithelium but also its ability to regenerate following damage. Using this research tool, the group of Prisca Liberali unraveled mechanisms orchestrating organoid formation and intestinal regeneration with a unique image-based screening approach. The researchers identified a compound that improves the regeneration of the intestine in vivo .

Life Sciences - Chemistry - Sep 21
Life Sciences - Chemistry

Loading of replicative helicases onto DNA is a key event during the initiation of chromosomal DNA replication. It takes place at specific chromosomal regions termed origins and is facilitated by the ORC protein complex. By resolving the cryo-EM structures of DNA-bound ORC, researchers from the Bleichert group (now at Yale) broaden our understanding of how DNA replication is initiated in animals.

Health - Life Sciences - Sep 8
Health - Life Sciences

The FMI is a partner of the pan-European LifeTime initiative. In two publications, researchers involved with the initiative - including FMI group leader Susan Gasser - present a detailed roadmap of how to leverage the latest scientific breakthroughs and technologies over the next decade, to track, understand and treat human cells throughout an individual's lifetime.

Research Management - Career - Sep 3

FMI group leader Johannes Felsenberg is among this year's recipients of a prestigious Starting Grant from the European Research Council (ERC). He will use the grant to study the neural processes that allow memories to be changed, using the fruit fly Drosophila as a model organism.

Life Sciences - Jul 21
Life Sciences

The group of Helge Grosshans characterized the " C. elegans oscillator", over 3,700 genes that are rhythmically expressed during the larval development of C. elegans .

Life Sciences - Sep 24
Life Sciences

DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, which increases the accessibility and flexibility of the DNA fiber and enhances the rate of homology search during repair by homologous recombination.

Life Sciences - Event - Sep 14
Life Sciences - Event

Due the covid-19 situation, we could not hold our FMI 50th Anniversary Symposium as planned. Instead, we organized a short video conference - for FMI members and our Scientific Advisory Board - to celebrate science virtually. The Award ceremonies for our three annual internal science prizes were at the heart of the meeting.

Life Sciences - Health - Sep 7
Life Sciences - Health

Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, tagging the target protein for degradation. In this new video, members of the Thomä group, in collaboration with the Broad Institute, explain how they identified and characterized a new molecular glue degrader compound called CR8, showing that it is unlike any of the previously identified molecular glue degraders.

Life Sciences - Chemistry - Aug 31
Life Sciences - Chemistry

Organoid? was launched today. It aims at validating organoids as faithful models of human biology, combining single-cell profiling and organoid technology.

Life Sciences - Chemistry - Jul 6
Life Sciences - Chemistry

The cytosolic iron sulfur assembly (CIA) pathway is required for the insertion of Fe-S clusters into proteins, including many DNA replication and repair factors. Despite its essential cellular function, this pathway remains enigmatic. A new integrative structural and biochemical study from the Thomä group now provides detailed insights into the mechanisms of Fe-S protein biogenesis.