Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research
Friedrich Miescher Institute for Biomedical Research  
Location: Basel
Discipline: Health
Affiliation: Novartis

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - Apr 17
Life Sciences
Chromatin remodelers have the ability to move nucleosomes, which represent a physical barrier for access to DNA. Work by the group of Dirk Schübeler helps to better understand how remodelers orchestrate the global organization of nucleosomes in mammals. In a study published in Nature, the researchers uncovered how two classes of remodelers selectively mediate the binding of distinct transcription factors.
Life Sciences - Apr 8

Guillaume Diss joined the FMI as a new Quantitative Biology group leader on March 1. His research focuses on understanding the mechanisms whereby genetic variation translates into phenotypic variation - for example, in diseases.

Life Sciences - Mar 19
Life Sciences

Epigenetic memory of transcriptional gene silencing has been observed in several organisms. However, it was not known whether mechanisms exist that convey transgenerational memory of a silencing “experience”, without silencing the gene permanently.

Life Sciences - Feb 26
Life Sciences

The heterochromatin of eukaryotes contains repetitive DNA, which can lead to genome instability when transcribed.

Life Sciences - Mar 25
Life Sciences

Puberty is a period of extensive changes of body morphology and function. As much as we are familiar with these life-altering changes, relatively little is known about what sets the whole process in motion.

Life Sciences - Mar 13

Five of our postdocs were recently awarded the prestigious EMBO and Maria Sklodowska-Curie Actions (MSCA) Fellowships. These grants are highly competitive and known worldwide for promoting innovative and interdisciplinary research.

Life Sciences - Feb 5
Life Sciences

Transcription of our genes mostly begins in regions of the genome called CpG islands. These are rich in the dinucleotide CpG (thus the name), critical for gene activity and devoid of DNA methylation.

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Medicine and Life Sciences