Friedrich Miescher Institute for Biomedical Research

Friedrich Miescher Institute for Biomedical Research
Basel
Friedrich Miescher Institute for Biomedical Research  
Location: Basel
Discipline: Health
Affiliation: Novartis

Understanding the mechanisms of disease

The Friedrich Miescher Institute is devoted to fundamental biomedical research aimed at understanding the basic molecular mechanisms of health and disease. We communicate and patent our findings to enable their translation into medical application. The FMI focuses on the fields of
  • Epigenetics
  • Growth control
  • Neurobiology
In these fields, the FMI has gained international recognition as a center of excellence in innovative biomedical research.

Training young scientists

Life Sciences - Health - Aug 17
Life Sciences - Health
Deubiquitinases (DUBs) play a general role removing protein-degrading ubiquitins throughout the cell and are not typically known for specificity. Analyzing the two protein complexes BRISC and BRCA1-A, which have the same DUB core but play different roles in human biology, the Thomä group - in a collaboration with the Novartis Institutes for BioMedical Research (NIBR) - showed that DUBs can have diversified targeting and regulatory functions.
Life Sciences - Health - Aug 5
Life Sciences - Health

The protein TRIM71 is an important regulator of animal development and plays a role in various diseases.

Life Sciences - Physics - Jun 10
Life Sciences - Physics

Characterizing chromosome structure is fundamental to a better understanding of gene expression. Current experimental methods helped to build mechanistic models of chromosome folding, however they could not be formally validated so far by independent techniques.

Life Sciences - May 22
Life Sciences

From yeast to man, the genome is partitioned into subnuclear compartments, with active euchromatin spatially separated from silent heterochromatin, which is often found at the nuclear periphery.

Life Sciences - Health - Apr 23
Life Sciences - Health

Our actions are driven by “internal states” such as anxiety, stress or thirst - which will strongly affect and motivate our behaviors.

Life Sciences - Health - Jul 21
Life Sciences - Health

DNA has become the icon of modern bioscience but few people realize that it was Friedrich Miescher, who - almost a century before Watson and Crick - laid the chemical groundwork for the molecular breakthroughs that followed.

Life Sciences - Physics - May 30
Life Sciences - Physics

UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by the DNA repair machinery, acting as a molecular sunscreen.

Health - Life Sciences - Apr 25
Health - Life Sciences

Intestinal organoids are three-dimensional structures derived from a single intestinal stem cell. They are great tools for applications ranging from fundamental biology to personalized and regenerative medicine.

Life Sciences - Apr 17
Life Sciences

Chromatin remodelers have the ability to move nucleosomes, which represent a physical barrier for access to DNA.




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Medicine and Life Sciences