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Life Sciences - Health - 07:02 
How a highly unstable protein may lead to neurodegeneration
Scientists reproduce key features of pathological protein aggregates found in the brain of patients with Lou Gehrig's disease and other neurological diseases, providing insight into the underlying mechanism and offering promising avenues for new therapies. Several neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Lou Gehrig's Disease aka Amyotrophic lateral sclerosis (ALS), are caused by proteins that go stray and start to aggregate into fibrils that accumulate in specific brain regions.
Pharmacology - Health - 01.06.2023 
New Class of Antibiotics to Fight Resistant Bacteria
Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.
Health - Pharmacology - 01.06.2023 
Rapid test for sepsis
In the case of blood poisoning, the bacteria in the blood must be identified as fast as possible so that a life-saving therapy can be started. researchers have now developed "sepsis sensors" with magnetic nanoparticles that detect bacterial pathogens within a short period of time and identify suitable candidates for antibiotic therapies.
Health - Life Sciences - 31.05.2023 
How the flu virus hacks our cells
A team from the University of Geneva has discovered how the influenza A virus hijacks the mechanism for importing iron into cells to invade its host. Influenza epidemics, caused by influenza A or B viruses, result in acute respiratory infection. They kill half a million people worldwide every year. These viruses can also wreak havoc on animals, as in the case of avian flu.
Life Sciences - Health - 26.05.2023 
4 new genetic variants associated with weight gain
A research group at the University of Lausanne has carried out the largest genome-wide study of weight gain induced by psychotropic drugs. This work has identified 4 new genetic variants associated with this metabolic disorder. Interindividual variability in psychotropic drug-induced weight gain The prevalence of metabolic disorders in the psychiatric population is a cause for concern, and particularly high among patients taking psychotropic drugs that induce weight gain.
Life Sciences - Health - 24.05.2023 
Thought-controlled walking again after spinal cord injury
Neuroscientists and neurosurgeons from EPFL/CHUV/UNIL and CEA/CHUGA/UGA report in the journal Nature that they have re-established the communication between the brain and spinal cord with a wireless digital bridge, allowing a paralyzed person to walk again naturally "We have created a wireless interface between the brain and the spinal cord using brain-computer interface (BCI) technology that transforms thought into action.", summarizes Grégoire Courtine, Professor of Neuroscience at EPFL, CHUV and UNIL.
Health - Physics - 24.05.2023 
New production process for therapeutic nanovesicles
Researchers at the University of Basel have developed an efficient method for the preparation of therapeutic nanovesicles, thereby fulfilling a key prerequisite for industrial production. The method also paves the way for research into areas such as immunotherapy treatments for cancer. Particles known as extracellular vesicles play a vital role in communication between cells and in many cell functions.
Health - 24.05.2023 
Designing synthetic receptors for precise cell control
Scientists at EPFL have developed a groundbreaking new technique for engineering biosensors that respond sensitively to specific biomolecules, enhancing cell migration and targeting in cancer treatment. The findings could lead to more precise control over cellular processes for a wide range of therapeutic applications.
Life Sciences - Health - 23.05.2023
Health - Life Sciences - 23.05.2023 
Supposedly rare diseases aren’t as rare as previously thought
Rare diseases are often caused by defects in genetic material. If children inherit only a defective gene from one parent, they often are asymptomatic -carriers or at least that was the previous assumption. However, a research team from the University of Basel and the University Hospital Basel is now reporting that such carriers can also suffer from life-threatening diseases - and that rare hereditary diseases are therefore probably more common than previously thought.
Health - Life Sciences - 22.05.2023 
Under control to the very end - how our cells kill themselves
Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. Researchers at the University of Basel have now been able to elucidate the exact mechanism at the atomic level.
Health - Pharmacology - 22.05.2023 
New vaccine concept against SARS-CoV-2 successfully tested
Researchers at the University of Basel have developed a new approach for a vaccine against COVID-19. This vaccine is based on a modified coronavirus that can enter body cells and trigger an effective immune response but cannot multiply in the body. In animal studies, the vaccine effectively protected against the disease and even prevented virus transmission.
Health - Pharmacology - 17.05.2023 
Mystery of important blood pressure drugs solved
Diuretic drugs from the thiazide group have been used for 60 years to treat high blood pressure. But they also increase the risk of developing diabetes. Researchers at the University of Bern and Inselspital have now pinpointed the cause of this side effect and in the process also gained new insights into the development of diabetes.
Pharmacology - Health - 17.05.2023 
New Treatment for Human Parasitic Worm Infections Shows High Efficacy
A new drug candidate shows promising results in treating parasitic worm infections. Re-searchers at Swiss TPH tested efficacy and safety of emodepside against the three most important soil-transmitted helminths on Pemba Island in Tanzania. Emodepside is the first new promising drug against parasitic worm infections since several decades.
Health - Pharmacology - 15.05.2023 
Clinically relevant deficiency of the ’bonding hormone’ oxytocin demonstrated
The hormone oxytocin is important for social interaction and to control emotions. A deficiency of this hormone has previously been assumed in various diseases such as autism, but has never been proven. Now, for the first time, researchers from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in patients with a deficiency of vasopressin caused by a disease of the pituitary gland.
Health - Life Sciences - 09.05.2023 
Ultra-long protein fibrils give clues on dementia risk
During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.
Life Sciences - Health - 08.05.2023 
Detailed image of the human retina
Researchers from Basel and Zurich are creating a high-resolution atlas that depicts the development of the human retina. One technique they use is a new method that allows them to visualise more than 50 proteins simultaneously. What cell types are found in which human tissue, and where? Which genes are active in the individual cells, and which proteins are found there? Answers to these questions and more are to be provided by a specialised atlas - in particular how the different tissues form during embryonic development and what causes diseases.
Health - Life Sciences - 04.05.2023 
Gene responsible for severe facial defects identified
A team from the University of Geneva and Beihang University reveals that the FOXI3 gene, responsible for ear development, is involved in Goldenhar syndrome. Goldenhar syndrome is a rare congenital disease, affecting early foetal development. This syndrome includes malformations of varying severity, affecting different parts of the face.
Life Sciences - Health - 03.05.2023 
A key mechanism of narcolepsy deciphered
A recent study is shaking up what is known about this condition, which is considered incurable, and could lead to a treatment. Orexin (also called hypocretin, or HCRT) is one of the most versatile neurotransmitters in the brain. It plays a role in motivation, energy metabolism and sleep/wake rhythms.
Health - Life Sciences - 03.05.2023 
How cells are influenced by their environment as tissues grow
The cells of our body interact with their immediate environment. Researchers have now studied this interaction in detail. In time, they hope to use these findings for improved diagnosis and treatment of wound-healing disorders and cancer. by Fabio Bergamin How does an embryo develop? How do children grow, wounds heal or cancer spread? All of this has to do with the growth of body tissue.
Health
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Scientists reproduce key features of pathological protein aggregates found in the brain of patients with Lou Gehrig's disease and other neurological diseases, providing insight into the underlying mechanism and offering promising avenues for new therapies. Several neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Lou Gehrig's Disease aka Amyotrophic lateral sclerosis (ALS), are caused by proteins that go stray and start to aggregate into fibrils that accumulate in specific brain regions.
Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.
In the case of blood poisoning, the bacteria in the blood must be identified as fast as possible so that a life-saving therapy can be started. researchers have now developed "sepsis sensors" with magnetic nanoparticles that detect bacterial pathogens within a short period of time and identify suitable candidates for antibiotic therapies.
A team from the University of Geneva has discovered how the influenza A virus hijacks the mechanism for importing iron into cells to invade its host. Influenza epidemics, caused by influenza A or B viruses, result in acute respiratory infection. They kill half a million people worldwide every year. These viruses can also wreak havoc on animals, as in the case of avian flu.
A research group at the University of Lausanne has carried out the largest genome-wide study of weight gain induced by psychotropic drugs. This work has identified 4 new genetic variants associated with this metabolic disorder. Interindividual variability in psychotropic drug-induced weight gain The prevalence of metabolic disorders in the psychiatric population is a cause for concern, and particularly high among patients taking psychotropic drugs that induce weight gain.
Neuroscientists and neurosurgeons from EPFL/CHUV/UNIL and CEA/CHUGA/UGA report in the journal Nature that they have re-established the communication between the brain and spinal cord with a wireless digital bridge, allowing a paralyzed person to walk again naturally "We have created a wireless interface between the brain and the spinal cord using brain-computer interface (BCI) technology that transforms thought into action.", summarizes Grégoire Courtine, Professor of Neuroscience at EPFL, CHUV and UNIL.
Researchers at the University of Basel have developed an efficient method for the preparation of therapeutic nanovesicles, thereby fulfilling a key prerequisite for industrial production. The method also paves the way for research into areas such as immunotherapy treatments for cancer. Particles known as extracellular vesicles play a vital role in communication between cells and in many cell functions.
Scientists at EPFL have developed a groundbreaking new technique for engineering biosensors that respond sensitively to specific biomolecules, enhancing cell migration and targeting in cancer treatment. The findings could lead to more precise control over cellular processes for a wide range of therapeutic applications.
How cells feed on RNA
Scientists have discovered that cells can use RNA and its constituent uridine as alternative energy sources to sugar. For better or for worse, as shown by their publication in "Nature Metabolism ". Each cell contains the genetic material necessary for the activity of the organism. RNA, or ribonucleic acid, is an important molecule for making proteins from the instructions contained in the genes.
Scientists have discovered that cells can use RNA and its constituent uridine as alternative energy sources to sugar. For better or for worse, as shown by their publication in "Nature Metabolism ". Each cell contains the genetic material necessary for the activity of the organism. RNA, or ribonucleic acid, is an important molecule for making proteins from the instructions contained in the genes.
Rare diseases are often caused by defects in genetic material. If children inherit only a defective gene from one parent, they often are asymptomatic -carriers or at least that was the previous assumption. However, a research team from the University of Basel and the University Hospital Basel is now reporting that such carriers can also suffer from life-threatening diseases - and that rare hereditary diseases are therefore probably more common than previously thought.
Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. Researchers at the University of Basel have now been able to elucidate the exact mechanism at the atomic level.
Researchers at the University of Basel have developed a new approach for a vaccine against COVID-19. This vaccine is based on a modified coronavirus that can enter body cells and trigger an effective immune response but cannot multiply in the body. In animal studies, the vaccine effectively protected against the disease and even prevented virus transmission.
Diuretic drugs from the thiazide group have been used for 60 years to treat high blood pressure. But they also increase the risk of developing diabetes. Researchers at the University of Bern and Inselspital have now pinpointed the cause of this side effect and in the process also gained new insights into the development of diabetes.
A new drug candidate shows promising results in treating parasitic worm infections. Re-searchers at Swiss TPH tested efficacy and safety of emodepside against the three most important soil-transmitted helminths on Pemba Island in Tanzania. Emodepside is the first new promising drug against parasitic worm infections since several decades.
The hormone oxytocin is important for social interaction and to control emotions. A deficiency of this hormone has previously been assumed in various diseases such as autism, but has never been proven. Now, for the first time, researchers from the University of Basel and the University Hospital of Basel have succeeded in demonstrating a deficiency of oxytocin in patients with a deficiency of vasopressin caused by a disease of the pituitary gland.
During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.
Researchers from Basel and Zurich are creating a high-resolution atlas that depicts the development of the human retina. One technique they use is a new method that allows them to visualise more than 50 proteins simultaneously. What cell types are found in which human tissue, and where? Which genes are active in the individual cells, and which proteins are found there? Answers to these questions and more are to be provided by a specialised atlas - in particular how the different tissues form during embryonic development and what causes diseases.
A team from the University of Geneva and Beihang University reveals that the FOXI3 gene, responsible for ear development, is involved in Goldenhar syndrome. Goldenhar syndrome is a rare congenital disease, affecting early foetal development. This syndrome includes malformations of varying severity, affecting different parts of the face.
A recent study is shaking up what is known about this condition, which is considered incurable, and could lead to a treatment. Orexin (also called hypocretin, or HCRT) is one of the most versatile neurotransmitters in the brain. It plays a role in motivation, energy metabolism and sleep/wake rhythms.
The cells of our body interact with their immediate environment. Researchers have now studied this interaction in detail. In time, they hope to use these findings for improved diagnosis and treatment of wound-healing disorders and cancer. by Fabio Bergamin How does an embryo develop? How do children grow, wounds heal or cancer spread? All of this has to do with the growth of body tissue.
