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Health - Pharmacology - 11.05.2022
The combination makes the difference: New therapeutic approach against breast cancer
The combination makes the difference: New therapeutic approach against breast cancer
Some breast tumors with certain genetic alterations are difficult to treat using existing therapies. Researchers at the University of Basel have now discovered an approach that involves a toxic combination with a second target gene in order to kill the abnormal cells. The first clinical trials could be starting soon.

Pharmacology - Health - 09.05.2022
Lymphomas: new model developed at the IOR against drug resistance
Lymphomas: new model developed at the IOR against drug resistance
The Lymphoma Genomics group, directed by Prof. Francesco Bertoni at the Institute of Oncology Research (IOR, affiliated to USI and member of Bios+), identified a new mechanism behind the resistance to the drug idelalisib, used in the treatment of patients with follicular lymphoma and marginal zone lymphoma.

Environment - Pharmacology - 02.05.2022
Bioassays evaluate ozonation and post-treatment of wastewater
Bioassays evaluate ozonation and post-treatment of wastewater
Through wastewater, rivers and lakes are polluted with numerous micropollutants which originate from care products and pharmaceuticals, among other things. The Waters Protection Act therefore aims to expand Swiss wastewater treatment plants (WWTP) with the addition of a further treatment step. In pilot tests, two processes have proven particularly successful in the removal of trace substances: ozonation and treatment with activated carbon.

Health - Pharmacology - 25.04.2022
Retina is not sparged by SARS-CoV-2
Retina is not sparged by SARS-CoV-2
The list of diseases caused by SARS-CoV-2 infection is growing and now includes the retina. This is what suggest a prospective study by the Geneva University Hospitals (HUG) and the University of Geneva. The list of diseases caused by SARS-CoV-2 infection is growing and now includes the retina. This is what suggest a prospective study by the Geneva University Hospitals (HUG) and the University of Geneva , in collaboration with the Adolphe de Rothschild Memorial Clinical Research Center for Ophthalmology.

Health - Pharmacology - 21.04.2022
Targeting ’anti-tumor’ genes to provide better treatment for leukemia
Scientists discuss the possibility of offering personalized treatment for chronic lymphocytic leukemia by regulating the expression of a gene known for its "anti-tumorous" properties. Chronic lymphocytic leukemia (CLL) is one of the most common blood cancers in adults. The disease originates in B cells - the part of the immune system that produces antibodies - and then evolves slowly, typically affecting older people.

Health - Pharmacology - 12.04.2022
COVID-19: Vaccination greatly reduces infectious viral load
By comparing the infectious viral load caused by ancestral SARS-CoV-2 as well as by the Delta and Omicron variants, scientists from the University of Geneva and HUG highlight the benefits of vaccination. To conduct the research, the UNIGE and HUG team was able to reanalyze samples from previous waves of the disease.

Pharmacology - Health - 29.03.2022
An approach to treating a severe congenital myopathy
An approach to treating a severe congenital myopathy
The diagnosis is rare, but devastating - children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital Basel are now presenting a possible therapeutic approach for the first time. Professor Susan Treves remembers seeing one child affected by the condition at the age of six months.

Health - Pharmacology - 08.03.2022
Origins of metastasis
Origins of metastasis
Researchers at the University of Geneva show that the experience of impending cell death within a primary  tumour can lead to the development of «pro-metastatic» cells. Metastatic cells form in a primary tumour and then break away from it, migrate to other organs, attach to them and form new tumours.

Health - Pharmacology - 25.02.2022
Gut Microbiota Influences Treatment against Parasitic Worms
Gut Microbiota Influences Treatment against Parasitic Worms
Almost a quarter of the world's population is at risk of helminth infections and available treatment options are limited. Therefore, a better understanding of why anti-parasitic drugs fail in certain cases is crucial. A new study by Swiss TPH sheds light on how gut bacteria affect treatment outcomes against parasitic worms.

Pharmacology - Health - 17.02.2022
Defeating leukaemia cells by depriving them of energy
Defeating leukaemia cells by depriving them of energy
A Swiss-French team that includes scientists has discovered how to trigger apoptosis in leukaemia cells by disrupting their energy maintenance mechanism. Acute myeloid leukaemia, which affects blood and bone marrow cells, is a particularly dangerous form of cancer. More than half of patients under the age of 60 die.

Life Sciences - Pharmacology - 10.02.2022
Illuminating Real-Time Brain Dynamics of Neuropeptides with a Fluorescent Biosensor
Illuminating Real-Time Brain Dynamics of Neuropeptides with a Fluorescent Biosensor
Neuropeptides play fundamental roles in modulating cellular and circuit functions within the brain. One such signaling molecule - orexin - regulates arousal and wakefulness, and its failure can lead to constant daytime sleepiness (narcolepsy). University of Zurich researchers have now developed a fluorescent orexin biosensor to observe this molecule "live" in the living mouse brain.

Health - Pharmacology - 02.02.2022
Immunological Memory Provides Long-Term Protection against Coronavirus
Immunological Memory Provides Long-Term Protection against Coronavirus
Exposure to SARS-CoV-2 by infection or vaccination generates immune cells that provide long-term immunity. These long-lived memory T cells play a key role in preventing severe cases of Covid-19. Researchers at the University of Zurich have now discovered how these memory T cells form. Many questions about how exposure to SARS-CoV-2 by infection or immunization might result in long-term protective immunity remain unanswered.

Life Sciences - Pharmacology - 01.02.2022
Localis-rex: a new tool for studying electrophile signaling
A team of researchers led by Professor Yimon Aye at EPFL's School of Basic Sciences has developed a new screening method to explore an important biological process known as electrophile signaling. In general, an electrophile is a highly reactive compound that -seeks- to bond with atoms or other molecules that have an available electron pair.

Health - Pharmacology - 13.01.2022
'It may be possible to prevent MS by means of vaccination.'
’It may be possible to prevent MS by means of vaccination.’
A large-scale study in the scientific journal Science reveals that the Epstein-Barr virus responsible for causing glandular fever is involved in the development of multiple sclerosis. Professor Jens Kuhle, who participated in the project, summarizes the results in an interview. Professor Kuhle, almost everyone is infected with the Epstein-Barr virus (EBV), usually without symptoms.

Life Sciences - Pharmacology - 10.01.2022
Improved motor, sensory, and cognitive recovery after stroke
Improved motor, sensory, and cognitive recovery after stroke
Stroke survivors have improved recovery of hand and arm function with the help a new rehabilitation protocol thanks to finely tuned electrostimulation of target muscles in the arm. After lying for a while in a way that puts pressure on a nerve in your arm, it may happen that you no longer feel your arm anymore.

Health - Pharmacology - 10.01.2022
Reasons for rejecting the initiative to ban animal and human experimentation in Switzerland
On 13 February 2022, Swiss citizens will be asked to vote on a popular initiative calling for a complete ban on all animal and human experimentation in Switzerland. The initiative also calls for a ban, from 2024, on all new drugs and medical treatments that have been tested on animals or humans, anywhere in the world.

Health - Pharmacology - 10.01.2022
AI offers a faster way to predict antibiotic resistance
AI offers a faster way to predict antibiotic resistance
Computer algorithms can determine antimicrobial resistance of pathogens faster than previous methods. This is the result of a study by researchers at the University of Basel, the University Hospital Basel and ETH Zurich. This could help treat serious infections more efficiently in the future - a major step forward in the battle against antibiotic-resistant bacteria.

Pharmacology - Life Sciences - 29.12.2021
Omicron's secrets revealed under a microscope
Omicron’s secrets revealed under a microscope
Thanks to the high-power electron microscopes at the Dubochet Center for Imaging (DCI), scientists were able to observe the configuration of the Omicron variant's spike protein at a near-atomic scale. This should provide fresh insight into the mechanisms the variant uses to evade vaccines and antibodies.

Health - Pharmacology - 15.12.2021
Effective combination cancer treatment
Effective combination cancer treatment
Researchers at the Paul Scherrer Institute PSI have tested various methods to check how effective they are in combatting certain types of cancer. They found a combination of two preparations to be much more effective than treatment with just one of the two active substances. They have published their findings today in the medical journal Pharmaceutics .

Health - Pharmacology - 07.12.2021
Rigidifying cancer cells for better immunotherapy
Rigidifying cancer cells for better immunotherapy
Scientists have found that stiffening the membranes of cancer cells can lead to improved immunotherapy outcomes. Preclinical tests show that it can increase long-term survival rates to nearly 50%. Immunotherapy is a promising form of cancer treatment that boosts patients' own T cells so that they can proliferate and destroy cancer cells.
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