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Pharmacology



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Health - Pharmacology - 15.04.2019
Precise Decoding of Breast Cancer Cells Creates New Option for Treatment
Researchers at the University of Zurich and from IBM Research have investigated the varying composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of tumor cell. If certain immune cells are present as well, an immune therapy could be successful for a specific group of breast cancer patients.

Health - Pharmacology - 11.04.2019
The way people walk says a lot about how healthy they are
The way people walk says a lot about how healthy they are
Gait characteristics are sometimes regarded as the sixth vital sign in humans. They serve as a valuable indicator of a person's health, particularly in older adults - so why not measure them? A team of EPFL researchers is taking part in a major European project to design a device that can assess a person's gait more accurately.

Health - Pharmacology - 28.03.2019
Breast cancer: the promises of old recipes
Breast cancer: the promises of old recipes
Researchers from UNIGE and UNIL demonstrate the efficacy of a well-known antibiotic in treating a particularly fatal form of breast cancer, offering hope for targeted therapy. Of the three major subtypes of breast cancer, the «triple negative» is the most lethal: half of all breast cancer deaths are attributed to it, whereas it accounts for only about 15% of incidences of breast cancer.

Health - Pharmacology - 13.03.2019
Stress hormones promote breast cancer metastasis
It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones. In addition, they found that synthetic derivatives of stress hormones, which are frequently used as anti-inflammatory in cancer therapy, decrease the efficacy of chemotherapy.

Pharmacology - Health - 04.03.2019
Novartis data confirm rapid response and high efficacy of Cosentyx in psoriasis patients for first time in China
Phase III study shows close to 9/10 patients who received Cosentyx 300mg achieved clear or almost clear skin during the first 16 weeks of treatment (87%), with rapid onset of relief seen as early as week 3   Results strengthen unique position of Cosentyx as a rapid and long-lasting complete treatment of psoriatic disease, with over 200,000 patients treated worldwide   Data is being presented at the 2019 American Academy of Dermatology (AAD) Annu

Health - Pharmacology - 08.02.2019
Drug-resistant tuberculosis: high mortality rate due to inaccurate tests
Drug-resistant tuberculosis: high mortality rate due to inaccurate tests
Inaccurate tests carried out on tuberculosis patients in developing countries often fail to reliably detect resistance to drugs, leading to incorrect treatment and a higher mortality rate. These are the results of study by an international group of researchers led by a team at the University of Bern published today.

Health - Pharmacology - 05.02.2019
Even psychological placebos have an effect
Even psychological placebos have an effect
Placebo effects do not only occur in medical treatment - placebos can also work when psychological effects are attributed to them. Psychologists from the University of Basel reported these findings in the journal Scientific Reports, based on three studies with over 400 participants. Psychotherapy and placebos are both psychological interventions that not only have comparable effects, but that are also based on very similar mechanisms.

Chemistry - Pharmacology - 01.02.2019
Intuition and failure are valuable ingredients in chemistry
Intuition and failure are valuable ingredients in chemistry
When researchers make a new discovery, they tend to only publish the results of their successful experiments. But just as informative are all the experiments that didn't work - the failed trials and incorrect hypotheses, which can offer important information. A team of EPFL chemists has developed a methodology for collecting those lessons and, crucially, sharing them with other researchers.

Health - Pharmacology - 14.01.2019
Conversion of breast cancer cells into fat cells impedes the formation of metastases
Conversion of breast cancer cells into fat cells impedes the formation of metastases
An innovative combination therapy can force malignant breast cancer cells to turn into fat cells. This can be used to prevent the formation of metastases in mice, as researchers at the University of Basel's Department of Biomedicine recently reported in the journal Cancer Cell. Tumor cells can adapt dynamically to changing conditions thanks to their ability to reactivate a cellular process that is central to embryonic development.

Health - Pharmacology - 10.01.2019
New drug against the formation of metastasis
New drug against the formation of metastasis
The most deadly aspect of breast cancer is metastasis. It spreads cancer cells throughout the body. Researchers at the University and the University Hospital of Basel have now discovered a substance that suppresses the formation of metastases. The development of metastasis is responsible for more than 90% of cancer-related deaths, and patients with a metastatic disease are considered incurable.

Pharmacology - Life Sciences - 10.01.2019
How Drugs Can Minimize the Side Effects of Chemotherapy
Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects. The results also provide important insights into how to develop compounds to effectively tackle other disorders.

Health - Pharmacology - 02.01.2019
Tumors backfire on chemotherapy
Chemotherapy is an effective treatment for breast cancer, yet some patients develop metastasis in spite of it. Researchers at EPFL have discovered that chemotherapy-treated mammary tumors produce small vesicles that may help them spread to other organs. The study is published. Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery.

Pharmacology - Health - 18.12.2018
Buruli Ulcer: Promising New Drug Candidate Against a Forgotten Disease
Buruli Ulcer: Promising New Drug Candidate Against a Forgotten Disease
Buruli ulcer is a neglected tropical disease (NTD) resulting in debilitating skin lesions, disabilities and stigmatisation. The current antibiotic treatment is long and has severe adverse side effects. Researchers from the Swiss Tropical and Public Health Institute (Swiss TPH) together with colleagues from Singapore have discovered a highly effective compound against Buruli ulcer which has the potential to become a powerful alternative to the existing treatment options.

Pharmacology - Health - 18.12.2018
Buruli ulcer: New drug against a forgotten disease
Buruli ulcer: New drug against a forgotten disease
Buruli ulcer is a neglected tropical disease (NTD) resulting in debilitating skin lesions and disabilities. The current antibiotic treatment is long and has severe adverse side effects. Researchers from the Swiss Tropical and Public Health Institute (Swiss TPH), which is associated with the University of Basel, together with colleagues from Singapore have discovered a highly effective compound against Buruli ulcer.

Health - Pharmacology - 14.12.2018
Modelling for New Schistosomiasis Treatment Thresholds
Modelling for New Schistosomiasis Treatment Thresholds
Schistosomiasis is a parasitic worm infection affecting 250 million people globally. The current prevalence thresholds for preventive chemotherapy of schistosomiasis are based on the Kato-Katz method using stool samples. A new more sensitive point-of-care urine test is now available in particular for settings with low prevalence.

Pharmacology - Health - 11.12.2018
Lethal combination: Drug cocktail turns off the juice to cancer cells
Lethal combination: Drug cocktail turns off the juice to cancer cells
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth - this was discovered by researchers from the University of Basel's Biozentrum two years ago. In a follow-up study, recently published in "Cell Reports", the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

Health - Pharmacology - 06.12.2018
Statins Overprescribed for Primary Prevention
Taking cholesterol-lowering drugs, or statins, as a preventive measure can reduce the risk of cardiovascular disease. A study by the University of Zurich now shows that this measure is recommended too often, as current guidelines fail to take into account the risks of side effects. Even healthy people who don't suffer from a cardiovascular disease are prescribed cholesterol-lowering drugs, known as statins, if they meet certain risk criteria.

Health - Pharmacology - 28.11.2018
New Stem-Cell Therapy to Improve Fight against Leukemia
Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue ' often with fatal consequences. Researchers at the University of Zurich have now identified a molecule that plays a key role in this process.

Pharmacology - Health - 19.11.2018
From Receptor Structure to New Osteoporosis Drugs
From Receptor Structure to New Osteoporosis Drugs
Researchers have determined the three-dimensional structure of a receptor that controls the release of calcium from bones. The receptor is now one of the main candidates for developing new drugs to treat osteoporosis. Knowing the receptor's blueprint will be instrumental for designing drugs that could even help to rebuild bones.

Health - Pharmacology - 22.10.2018
Roche’s Alecensa (alectinib) significantly reduced the risk of disease worsening or death as a first-line treatment in Asian patients with ALK-positive advanced or metastatic non-small cell lung cancer
Roche's Alecensa (alectinib) significantly reduced the risk of disease worsening or death as a first-line treatment in Asian patients with ALK-positive advanced or metastatic non-small cell lung cancer Head-to-head phase III study of Alecensa versus crizotinib in Asian patient population showed a reduction in the risk of disease worsening or death by 78% Alecensa lowered the risk of tumour spread or growth in the brain or central nervous system