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Health - Pharmacology - 28.05.2020
Geneva study against SARS-CoV-2 gets underway
Geneva study against SARS-CoV-2 gets underway
Geneva University Hospitals (HUG), the University of Geneva , the Infectious Disease Research Centre at Laval University in Quebec (Canada) and MaxiVAX - a Geneva-based company specialising in biotechnology - are working together to develop a SARS-CoV-2 vaccine. This joint research programme aims to create a vaccine combining an immunostimulator and a specific coronavirus target, namely the spike surface protein.

Health - Pharmacology - 21.05.2020
Mastocytosis drug improves symptoms and quality of life
Mastocytosis drug improves symptoms and quality of life
From itching, abdominal pain and exhaustion to unconsciousness: the drug midostaurin can help alleviate these symptoms and improve quality of life in patients with mastocytosis. This has been proven by a research group at the University of Basel. Their findings have been published in the Journal of Allergy and Clinical Immunology.

Health - Pharmacology - 14.05.2020
Molecular Signatures can Predict the Efficacy of Malaria Vaccines
Molecular Signatures can Predict the Efficacy of Malaria Vaccines
A new study reveals that it is possible to identify those individuals that will be protected by the malaria vaccine before its administration. The researchers also found that boosting the immune system before vaccination could potentially improve vaccine efficacy. The study was published yesterday in Science Translational Medicine by ISGlobal in partnership with the Swiss Tropical and Public Health Institute and other partners.

Life Sciences - Pharmacology - 11.05.2020
Peptides that can be taken as a pill
Peptides that can be taken as a pill
Peptides represent a billion-dollar market in the pharmaceutical industry, but they can generally only be taken as injections to avoid degradation by stomach enzymes. Scientists at EPFL have now developed a method to generate peptides that resist enzymatic degradation and can be taken orally. Peptides are short chains of amino acids that occur in our body, in plants or bacteria to control diverse functions.

Health - Pharmacology - 11.05.2020
IOR researchers suggest that androgen-deprivation treatments for prostate cancer could protect men from COVID-19
The so-called "androgen-deprivation" treatments used in prostate cancer therapy may have a protective effect against COVID-19. A study conducted by the Istitute of Oncology Research (IOR, affiliated to USI) based on health data obtained from the Veneto region in Italy has observed a lower risk of developing the coronavirus disease for men subject to this type of therapy.

Health - Pharmacology - 07.05.2020
Prostate cancer treatment may protect from COVID-19
Androgen-deprivation therapy could protect against infection with SARS-CoV-2 and against severe disease progression. This is suggested by a study led by a professor from the Universitą della Svizzera Italiana and ETH Zurich. Male cancer patients have a 1.8-fold increased risk of COVID-19 infection compared to the whole male population and develop a more severe disease.

Health - Pharmacology - 30.04.2020
High Cost of Cancer Drugs Not Always Justified
High Cost of Cancer Drugs Not Always Justified
Do high prices of some cancer medicines have a higher benefit than those drugs with lower prices' An international UZH study has concluded that, in general, there is no correlation between costs of a cancer drugs and their clinical benefit. The researchers are therefore calling for the clinical benefit of drugs to be better reflected in pricing.

Health - Pharmacology - 23.04.2020
A new therapeutic target turns the immune system against lymphoma
A new therapeutic target turns the immune system against lymphoma
EPFL scientists have identified a key mechanism that tumor cells use to take advantage of and avoid detection from the immune system. Targeting this mechanism offers a new therapeutic strategy for cancers like Non-Hodgkin lymphoma. Non-Hodgkin lymphoma (NHL) is a group of cancers that originate in the lymph nodes and affect white blood cells of the immune system called B cells.

Pharmacology - Health - 21.04.2020
Into drugs and vaccines to combat Covid-19
Into drugs and vaccines to combat Covid-19
As the world anxiously awaits a remedy for the novel coronavirus, ETH Zurich is also involved in the search for active substances and vaccines. This overview sets out the therapeutic approaches pursued by ETH researchers. As yet, there is still no reliable treatment for Sars-CoV-2. However, scientists across Switzerland and worldwide are engaged in an intensive search for an effective agent against the pathogen responsible for the Covid-19 pandemic.

Health - Pharmacology - 20.04.2020
Towards a therapy against prostate cancer metastasis
Towards a therapy against prostate cancer metastasis
An international group of researchers, led by the Institute of Oncology Research (IOR, affiliated to USI), has discovered a mechanism to recognise the cancer cells responsible for prostate cancer and selectively eliminate them. The study was published on April 6 by the Journal of Clinical Investigation (JCI).

Pharmacology - Health - 20.04.2020
Novartis to sponsor clinical trial of hydroxychloroquine in COVID-19 patients
Novartis to sponsor clinical trial of hydroxychloroquine in COVID-19 patients
Novartis has reached an agreement with the US Food and Drug Administration (FDA) to proceed with a Phase III clinical trial of hydroxychloroquine in hospitalized patients with COVID-19 disease.

Health - Pharmacology - 17.04.2020
Sleeping Sickness Elimination at a Crossroads
Sleeping Sickness Elimination at a Crossroads
Human African trypanosomiasis, also known as HAT or sleeping sickness, is a vector-borne parasitic disease. Since the number of new cases reported between 2000 and 2018 dropped by 95%, the World Health Organization (WHO) targeted its elimination as a public health problem by 2020 and interruption of transmission (zero cases) for 2030; but there is still much work to be done.

Pharmacology - Health - 23.03.2020
IOR lays the foundation for a new clinical trial against lymphomas
IOR lays the foundation for a new clinical trial against lymphomas
A study conducted by med.  Francesco Bertoni at the Institute of Oncology Research ( IOR , affiliated to USI) has shown that a specific combination of drugs is a potentially winning strategy in the fight against lymphomas. The results obtained in the laboratory have enabled the researchers at the Istituto Oncologico della Svizzera italiana ( IOSI ) to develop a clinical study together with the Swiss Group for Clinical Cancer Research ( SAKK ).

Health - Pharmacology - 09.03.2020
Circulatory failure is predictable
Circulatory failure is predictable
Researchers at ETH Zurich and Bern University Hospital have developed a method for predicting circulatory failure in patients in intensive care units - enabling clinicians to intervene at an early stage. Their approach uses machine learning methods to evaluate an extensive body of patient data. Patients in a hospital's intensive care unit are kept under close observation: clinicians continuously monitor their vital signs such as their pulse, blood pressure and blood oxygen saturation.

Health - Pharmacology - 21.02.2020
A better diagnosis of rare diabetes to adapt treatment
A better diagnosis of rare diabetes to adapt treatment
Scientists highlight the importance of monogenic diabetes and the consequences in terms of care of a precise diagnosis. Diabetes affects more than 400 million people worldwide and is a major public health problem. Although commonly referred to as a single disease, it actually constitutes a group of metabolic disorders with hyperglycaemia as a common feature.

Health - Pharmacology - 20.02.2020
Decision time predicts the risk of depression relapse
Decision time predicts the risk of depression relapse
In a study, researchers have shown that it is possible to predict the risk of relapsing into depression after stopping antidepressant medication. People who relapse take longer to decide how much effort to invest for a reward. Depressive disorder is a major public health problem with an unpredictable course.

Pharmacology - Health - 10.02.2020
Personalized cancer vaccines
Personalized cancer vaccines
The only therapeutic cancer vaccine available on the market has so far showed very limited efficacy in clinical trials. EPFL researchers are currently working on an alternative. They have developed a platform that allows a cancer vaccine to be delivered to a precise location and stimulate the immune system in a safe way - thereby overcoming one of the two obstacles to creating an effective vaccine.

Pharmacology - Health - 06.02.2020
New Understanding of Childhood Immune Systems May Improve Vaccine Efficacy
New Understanding of Childhood Immune Systems May Improve Vaccine Efficacy
In lowand middle-income countries, children have the greatest need for protection afforded by vaccination due to a higher incidence of infectious diseases. However, the vaccines for these children often show a lower efficacy when compared to similar populations in high-income settings. A new study by the Swiss Tropical and Public Health Institute (Swiss TPH) and partners from the Babraham Institute, ISGlobal and others published yesterday in Science Translational Medicine reveals that the immune system of children varies according to age, location and anaemia status.

Pharmacology - Health - 03.02.2020
Designing an emergency stop switch for immunotherapies
Designing an emergency stop switch for immunotherapies
CAR T-cell therapy is a highly promising treatment strategy for tumors, but is associated with life-threatening side effects. Researchers at EPFL, UNIL and CHUV have developed a new way to "switch off" the therapy when a cancer patient's life is in danger, paving the way for safer immunotherapy approaches to target solid tumors.

Health - Pharmacology - 20.01.2020
Refining Breast Cancer Classification by Multiplexed Imaging
Refining Breast Cancer Classification by Multiplexed Imaging
An imaging approach developed at UZH enables the study of breast cancer tissue in greater detail. It uses 35 biomarkers to identify the different cell types in breast tumors and its surrounding area compared to the current standard of testing single markers. This increases the precision of tumor analysis and classification - and improves personalized diagnostics for breast cancer patients.
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