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Health - Pharmacology - 23.10.2020
School children benefit from preventive malaria treatment
A large study shows that preventive treatment of children with antimalarial drugs reduces clinical malaria and anaemia in sub-Saharan Africa. In several regions affected by the tropical disease malaria there are programmes in schools to preventively treat children with antimalarial drugs. An international consortium of researchers, including Michael Zimmermann, Professor of Human Nutrition at ETH Zurich, has now for the first time analysed the effectiveness of such programmes in a meta-analysis using individual data.

Pharmacology - Health - 06.10.2020
Colorectal cancer treatment: the winning combinations
Colorectal cancer treatment: the winning combinations
A technique developed by scientists from the University of Geneva and HUG has made it possible to identify in vitro and validate in vivo, an optimised combination of anticancer drugs that are more effective than chemotherapy and that do not have side effects. A schematic drawing of colon and colorectal carcinoma.

Life Sciences - Pharmacology - 05.10.2020
Millimetre-precision drug delivery to the brain
Millimetre-precision drug delivery to the brain
Focused ultrasound waves help ETH researchers to deliver drugs to the brain with pinpoint accuracy, in other words only to where their effect is desired. This method is set to enable treatment of psychiatric and neurological disorders and tumours with fewer side effects in the future. Researchers at ETH Zurich have developed a method for concentrating and releasing drugs in the brain with pinpoint accuracy.

Health - Pharmacology - 30.09.2020
New research from Ticino on the antibody response to SARS-CoV-2
New research from Ticino on the antibody response to SARS-CoV-2
After the announcement, in May, of the first results of serological tests carried out on healthcare personnel in Ticino [ www.usi.ch/en/feeds/13622 ], significant data on the antibody response to SARS-CoV-2 is now available, thanks to the analysis carried out - among others - by the Institute for Research in Biomedicine (IRB, affiliated to USI) and Humabs BioMed (subsidiary of Vir Biotechnology), in close collaboration with hospitals and COVID-19 centers in Ticino (Ente Ospedaliero Cantonale EOC and Clinica Luganese Moncucco).

Health - Pharmacology - 28.09.2020
New technique for ultrafast tumour therapy
New technique for ultrafast tumour therapy
For the first time, researchers at the Centre for Proton Therapy at the Paul Scherrer Institute PSI in Switzerland have tested ultrafast, high-dose irradiation with protons. This new, experimental FLASH technique could revolutionise radiation therapy for cancer and save patients many weeks of treatment.

Pharmacology - 21.09.2020
An acoustically actuated microscopic device
An acoustically actuated microscopic device
Researchers at EPFL have developed remote-controlled, mechanical microdevices that, when inserted into human tissue, can manipulate the fluid that surrounds them, collect cells or release drugs. This breakthrough offers numerous potential applications in the biomedical field, from diagnostics to therapy.

Health - Pharmacology - 18.09.2020
Increasing the effectiveness of immunotherapy against skin cancer
Researchers at the University of Bern have discovered a mechanism in the body's own immune system which is responsible for the maturing and activation of immune cells. In the fight against skin cancer, the results have the potential to help immunotherapy succeed, even for patients on whom it previously had no effect.

Pharmacology - Chemistry - 17.09.2020
Computational pharmacology ’made in USI’ scores again
Another important result for research in computational pharmacology "made in USI": Prof. Vittorio Limongelli of the Faculty of Biomedical Sciences and his PhD candidate Stefano Raniolo have developed a protocol that allows to simulate accurately the interaction between a drug and its molecular "target".

Health - Pharmacology - 15.09.2020
Only One Third of Children Receive Appropriate Malaria Care
Only One Third of Children Receive Appropriate Malaria Care
Despite lots of progress made in the past decade, more than 270,000 children die from Malaria each year. Most of these deaths could be avoided through timely diagnosis and treatment. Despite better availability of tests and medication, a new study shows that large gaps remain in the quality of malaria care for children.

Pharmacology - Life Sciences - 04.08.2020
Blood-thinner with no bleeding side-effects is here
Blood-thinner with no bleeding side-effects is here
In a study led by EPFL, scientists have developed a synthetic blood-thinner that, unlike all others, doesn't cause bleeding side-effects. The highly potent, highly selective, and highly stable molecule can suppress thrombosis while letting blood clot normally following injury. Patients who suffer from thrombosis, pulmonary embolism or stroke are usually put on drugs that help their blood flow more smoothly through their body.

Pharmacology - Chemistry - 31.07.2020
Towards faster drug design
Towards faster drug design
A powerful new computational tool to identify the most promising pharmacological compounds and thus allow a much faster "screening". That is what has been developed thanks to the research carried out by Prof. Vittorio Limongelli's group of USI Faculty of Biomedical Sciences in collaboration with Prof. Siewert Marrink's group of University of Groningen (Netherlands).

Health - Pharmacology - 30.07.2020
New approach for targeted cancer immunotherapy
New approach for targeted cancer immunotherapy
A new study from researchers at the University of Basel demonstrates that a novel cancer immunotherapy, based on a locally focused activation of immune cells, could help to more efficiently eradicate tumor cells and reduce side effects. Cancer immunotherapies make use of the ability of the immune system to attack cancer cells: they unleash the killer function of T cells, which then attack and eradicate the cancer cells.

Health - Pharmacology - 23.07.2020
Iron deficiency during infancy reduces vaccine efficacy
About 40 percent of children around the globe suffer from anaemia because they do not consume enough iron. Now, studies by ETH researchers show that iron deficiency also reduces the protection provided by vaccinations. Despite the fact that global immunisation programmes are now reaching more people than ever, about 1.5 million children still die every year from diseases that vaccination could have prevented.

Health - Pharmacology - 22.07.2020
Primary care physicians during the COVID Epidemic-19
With a study covering 1,500 ambulatory patients, a team from the University of Geneva is highlighting the crucial role that general practitioners could play in the control of COVID-19. The global crisis triggered by COVID-19 has led governments to rely on the expertise of specialists in defining health emergency policies.

Pharmacology - Health - 15.07.2020
Blueprint of Oxytocin Receptor Facilitates Development of New Autism Drugs
Blueprint of Oxytocin Receptor Facilitates Development of New Autism Drugs
Oxytocin plays a role in various mental health and sexual reproduction disorders. Researchers at the University of Zurich have now determined the three-dimensional structure of the oxytocin receptor to which the hormone binds. This knowledge could promote the development of novel drugs to treat a variety of diseases.

Health - Pharmacology - 10.07.2020
Basel study: Why lopinavir and lopinavir and hydroxychloroquine do not work on Covid-19
Basel study: Why lopinavir and lopinavir and hydroxychloroquine do not work on Covid-19
Lopinavir is a drug against HIV, hydroxychloroquine is used to treat malaria and rheumatism. Until recently, both drugs were regarded as potential agents in the fight against the coronavirus SARS-CoV-2. A research group from the University of Basel and the University Hospital has now discovered that the concentration of the two drugs in the lungs of Covid-19 patients is not sufficient to fight the virus.

Pharmacology - Life Sciences - 11.06.2020
Solving a Parkinson's disease puzzle through protein design
EPFL researchers, in collaboration with UTSW and UCSD scientists, have developed a computational protein design approach, and used it to obtain the first ever high-resolution structure of an activated dopamine receptor in its natural cell membrane environment. The breakthrough will open up a new dimension in drug discovery for Parkinson's disease and perhaps other disorders.

Health - Pharmacology - 05.06.2020
Gene therapy to reverse vision loss in macular degeneration
Gene therapy to reverse vision loss in macular degeneration
Researchers have developed a strategy that has the potential to improve vision in patients with macular degeneration in the future. Using a gene therapy, they sensitized blind retinas of mice and human organ donors to near-infrared light. The team based at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) has published its results .

Health - Pharmacology - 28.05.2020
Geneva study against SARS-CoV-2 gets underway
Geneva study against SARS-CoV-2 gets underway
Geneva University Hospitals (HUG), the University of Geneva , the Infectious Disease Research Centre at Laval University in Quebec (Canada) and MaxiVAX - a Geneva-based company specialising in biotechnology - are working together to develop a SARS-CoV-2 vaccine. This joint research programme aims to create a vaccine combining an immunostimulator and a specific coronavirus target, namely the spike surface protein.

Health - Pharmacology - 21.05.2020
Mastocytosis drug improves symptoms and quality of life
Mastocytosis drug improves symptoms and quality of life
From itching, abdominal pain and exhaustion to unconsciousness: the drug midostaurin can help alleviate these symptoms and improve quality of life in patients with mastocytosis. This has been proven by a research group at the University of Basel. Their findings have been published in the Journal of Allergy and Clinical Immunology.
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