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Pharmacology - Health - 23.03.2020
IOR lays the foundation for a new clinical trial against lymphomas
IOR lays the foundation for a new clinical trial against lymphomas
A study conducted by med.  Francesco Bertoni at the Institute of Oncology Research ( IOR , affiliated to USI) has shown that a specific combination of drugs is a potentially winning strategy in the fight against lymphomas. The results obtained in the laboratory have enabled the researchers at the Istituto Oncologico della Svizzera italiana ( IOSI ) to develop a clinical study together with the Swiss Group for Clinical Cancer Research ( SAKK ).

Health - Pharmacology - 09.03.2020
Circulatory failure is predictable
Circulatory failure is predictable
Researchers at ETH Zurich and Bern University Hospital have developed a method for predicting circulatory failure in patients in intensive care units - enabling clinicians to intervene at an early stage. Their approach uses machine learning methods to evaluate an extensive body of patient data. Patients in a hospital's intensive care unit are kept under close observation: clinicians continuously monitor their vital signs such as their pulse, blood pressure and blood oxygen saturation.

Health - Pharmacology - 21.02.2020
A better diagnosis of rare diabetes to adapt treatment
A better diagnosis of rare diabetes to adapt treatment
Scientists highlight the importance of monogenic diabetes and the consequences in terms of care of a precise diagnosis. Diabetes affects more than 400 million people worldwide and is a major public health problem. Although commonly referred to as a single disease, it actually constitutes a group of metabolic disorders with hyperglycaemia as a common feature.

Health - Pharmacology - 20.02.2020
Decision time predicts the risk of depression relapse
Decision time predicts the risk of depression relapse
In a study, researchers have shown that it is possible to predict the risk of relapsing into depression after stopping antidepressant medication. People who relapse take longer to decide how much effort to invest for a reward. Depressive disorder is a major public health problem with an unpredictable course.

Pharmacology - Health - 10.02.2020
Personalized cancer vaccines
Personalized cancer vaccines
The only therapeutic cancer vaccine available on the market has so far showed very limited efficacy in clinical trials. EPFL researchers are currently working on an alternative. They have developed a platform that allows a cancer vaccine to be delivered to a precise location and stimulate the immune system in a safe way - thereby overcoming one of the two obstacles to creating an effective vaccine.

Pharmacology - Health - 06.02.2020
New Understanding of Childhood Immune Systems May Improve Vaccine Efficacy
New Understanding of Childhood Immune Systems May Improve Vaccine Efficacy
In lowand middle-income countries, children have the greatest need for protection afforded by vaccination due to a higher incidence of infectious diseases. However, the vaccines for these children often show a lower efficacy when compared to similar populations in high-income settings. A new study by the Swiss Tropical and Public Health Institute (Swiss TPH) and partners from the Babraham Institute, ISGlobal and others published yesterday in Science Translational Medicine reveals that the immune system of children varies according to age, location and anaemia status.

Pharmacology - Health - 03.02.2020
Designing an emergency stop switch for immunotherapies
Designing an emergency stop switch for immunotherapies
CAR T-cell therapy is a highly promising treatment strategy for tumors, but is associated with life-threatening side effects. Researchers at EPFL, UNIL and CHUV have developed a new way to "switch off" the therapy when a cancer patient's life is in danger, paving the way for safer immunotherapy approaches to target solid tumors.

Health - Pharmacology - 20.01.2020
Refining Breast Cancer Classification by Multiplexed Imaging
Refining Breast Cancer Classification by Multiplexed Imaging
An imaging approach developed at UZH enables the study of breast cancer tissue in greater detail. It uses 35 biomarkers to identify the different cell types in breast tumors and its surrounding area compared to the current standard of testing single markers. This increases the precision of tumor analysis and classification - and improves personalized diagnostics for breast cancer patients.

Health - Pharmacology - 13.01.2020
Reducing the risk of blood clots in artificial heart valves
Reducing the risk of blood clots in artificial heart valves
People with mechanical heart valves need blood thinners on a daily basis, because they have a higher risk of blood clots and stroke. Researchers at the ARTORG Center of the University of Bern, Switzerland, now identified the root cause of blood turbulence leading to clotting. Design optimization could greatly reduce the risk of clotting and enable these patients to live without life-long medication.

Life Sciences - Pharmacology - 16.12.2019
A new druggable step in the gene expression pathway
A new druggable step in the gene expression pathway
Thanks to their expertise in single-molecule imaging of RNAs, researchers from the group of Jeff Chao at the FMI helped to reveal the biological mechanism of a small molecule that restricts Ewing's sarcoma cell growth. The study - published - is further evidence that each step of the gene expression pathway may be druggable, and a great example of a Novartis-FMI collaboration.

Pharmacology - Health - 14.12.2019
Excessive Rates of Antibiotic Prescriptions for Children in Low- and Middle-Income Countries
Excessive Rates of Antibiotic Prescriptions for Children in Low- and Middle-Income Countries
Between 2007 and 2017, children in eight lowand middle-income countries received, on average, 25 antibiotic prescriptions from birth through age five - up to five times higher than the already high levels observed in high-income settings. Many of the prescriptions are unnecessary and might exacerbate resistance.

Life Sciences - Pharmacology - 02.12.2019
Designing and re-purposing cell receptors
Designing and re-purposing cell receptors
EPFL scientists have developed a computational method modeling and designing protein allostery that allows the accurate and rational engineering and even re-purposing of cell receptors. The method can be a significant tool for drug development. Called the "second secret of life", allostery is one of the most fundamental processes of biology and has been a central focus among scientists across the life sciences spectrum, from fundamental biology to drug development.

Health - Pharmacology - 02.12.2019
Big Data makes intensive care better
Big Data makes intensive care better
Patient safety in intensive care units could be significantly improved if false alarms could be greatly reduced and critical complications such as epileptic seizures could be predicted. This is where the "ICU Cockpit" project of the National Research Programme "Big Data" (NRP 75) comes in: The large amounts of data from intensive care medicine will be used to develop procedures for early warning systems and therapeutic recommendations.

Pharmacology - Life Sciences - 26.11.2019
New Migraine Medications Could Endanger Patients with High Blood Pressure
New migraine medications block αCGRP, a neuropeptide which causes vasodilation, for example in the meninges. The very same peptide, which is formed in the muscles during physical activity, protects the heart ' which is vital for people with chronic high blood pressure. The innovative migraine prophylaxis could endanger these people, as researchers at the University of Zurich have demonstrated in mice.

Health - Pharmacology - 06.11.2019
"Super-grafts" that could treat diabetes
By successfully strengthening pancreatic islets before transplantation, researchers at UNIGE and HUG are hoping for a significant improvement in the success of cell transplants in patients with severe diabetes. To save patients with a severe form of type 1 diabetes (characterized by the absence of functional insulin-producing cells), pancreatic cell transplantation is sometimes the last resort.

Health - Pharmacology - 31.10.2019
Removing liver tumors safely, noninvasively and efficiently
Removing liver tumors safely, noninvasively and efficiently
Many liver tumors have long been difficult or impossible to remove. Since 2015, however, it has been possible to treat these tumors by combining noninvasive surgical techniques, radiological imaging and a navigation system. For the first time, a new study by University of Bern and Inselspital, Berne University Hospital has impressively demonstrated the success of this technique.

Pharmacology - Psychology - 24.10.2019
Mindfulness Meditation Enhances Positive Effects of Psilocybin
Mindfulness Meditation Enhances Positive Effects of Psilocybin
Recent years have seen a renewed interest in the clinical application of classic psychedelics in the treatment of depression and anxiety disorders. Researchers of the University of Zurich have now shown that mindfulness meditation can enhance the positive long-term effects of a single dose of psilocybin, which is found in certain mushrooms.

Pharmacology - Life Sciences - 23.10.2019
Antibiotics with Novel Mechanism of Action Discovered
Many life-threatening bacteria are becoming increasingly resistant to existing antibiotics. Swiss researchers co-headed by the University of Zurich have now discovered a new class of antibiotics with a unique spectrum of activity and mechanism of action - a major step in the fight against antimicrobial resistance.

Pharmacology - 23.10.2019
Drugs are consumed everywhere, but not always the same ones
Drugs are consumed everywhere, but not always the same ones
This spring, as they have now done for the past eight years, the international research team SCORE (Sewage analysis CORe group Europe), co-founded by Christoph Ort from Eawag, once again examined the wastewater from European metropolises for four illegal drugs - amphetamine, cocaine, MDMA (Ecstasy) and methamphetamine.

Health - Pharmacology - 16.10.2019
Diabetes: a next-generation therapy soon available?
Diabetes: a next-generation therapy soon available?
By identifying a protein that helps regulate blood glucose and lipids, researchers at UNIGE hope for the rapid development of treatments more effective than current insulin therapy. Insulin, a hormone essential for regulating blood sugar and lipids, is normally produced by pancreatic - cells. In many people with diabetes, however, pancreatic cells are not (or no longer) functional, causing a chronic and potentially fatal insulin deficiency that can only be controlled through daily insulin injections.
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