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Life Sciences - Pharmacology - 14.10.2019
Tissue damage caused by a heart attack to be reduced by 30%?
Tissue damage caused by a heart attack to be reduced by 30%?
Scientists from the Universities of Geneva and Lyon have discovered which molecule is held responsible for tissue necrosis due to an infarctus, and how to reduce the tissue damage by 30% in mice. Each year, heart attacks kill almost 10 million people in the world, and more than 6 million die from stroke.

Pharmacology - Health - 24.09.2019
WHO modifies its recommendations on HIV
WHO modifies its recommendations on HIV
The first results of the NAMSAL study, conducted by Swiss, French and Cameroonian teams, have enabled WHO to revise its AIDS treatment recommendations to better adapt them to the most diverse contexts. Until very recently, the World Health Organization (WHO) recommended two drugs  - dolutegravir and efavirenz  - for the treatment of HIV infection.

Health - Pharmacology - 19.09.2019
Advanced AI boosts clinical analysis of eye images
Advanced AI boosts clinical analysis of eye images
A fast and reliable machine learning tool, developed by the ARTORG Center, University of Bern and the Department of Ophthalmology, Inselspital brings Artificial Intelligence (AI) closer to clinical use in Ophthalmology. The novel method published in Nature Scientific Reports on September 19, 2019 presents a tool that reliably extracts meaning from extensive image data.

Pharmacology - Health - 18.09.2019
Positive results from Novartis five-year VERIFY study in type 2 diabetes demonstrate long-term clinical benefits of early combination treatment with Galvus and metformin
Early combination treatment strategy with vildagliptin (Galvus ) and metformin was superior to standard of care in newly diagnosed type 2 diabetes patients ,   The landmark VERIFY study is the first to investigate the long-term clinical benefits of this early combination strategy in type 2 diabetes (T2DM)   Novartis is committed to optimizing patient management of T2DM to achieve better glycemic control and favorable long-term clinical outcomes 

Health - Pharmacology - 18.09.2019
AI-based prognosis in intensive care: decision-relevant patterns identified in EEG of coma patients
AI-based prognosis in intensive care: decision-relevant patterns identified in EEG of coma patients
A reliable prognosis for coma patients in the intensive care unit is crucial. Improved transparency will boost the use of Artificial Intelligence (AI) to support end-of-life decisions. For the first time, a research team has succeeded in identifying specific patterns in Electro-Encephalogram (EEG) analyses that the deep-learning network uses for making prognosis decisions.

Pharmacology - Health - 10.09.2019
Multiple sclerosis therapy: scientists identify the Achilles' heel of a therapeutic antibody and find a solution to avoid the problem
Multiple sclerosis therapy: scientists identify the Achilles’ heel of a therapeutic antibody and find a solution to avoid the problem
An international research team led by the Institute for Research in Biomedicine, affiliated to the Università della Svizzera italiana, has discovered why some patients with multiple sclerosis make an immune reaction that curtails the effectiveness of natalizumab, a therapeutic antibody used for the treatment of the disease and used this information to engineer a new version of the antibody that avoids this problem.

Pharmacology - Health - 22.08.2019
Preventing tumour metastasis
Preventing tumour metastasis
Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an agent against the metastasis of certain cancers. Using the Swiss Light Source, they deciphered the structure of a receptor that plays a crucial role in the migration of cancer cells.

Health - Pharmacology - 07.08.2019
Tiny biodegradable circuits for releasing painkillers inside the body
Tiny biodegradable circuits for releasing painkillers inside the body
EPFL researchers have developed biodegradable microresonators that can be heated locally with a wireless system. Doctors could soon be using them in implants to control the release of painkillers within tissue. Patients fitted with an orthopedic prosthetic commonly experience a period of intense pain after surgery.

Pharmacology - Health - 05.08.2019
Future clinical studies in lymphoma patients
At the Institute of Oncology Research (IOR, affiliated to USI), researchers have discovered two molecules, so far known in the field of treatments against Ewing's sarcoma, which have strong antilymphoma activity, thus proposing clinical studies on patients. The study has been published in the scientific journal Clinical Cancer Research .

Life Sciences - Pharmacology - 11.07.2019
A novel perception mechanism regulating important plant processes
A novel perception mechanism regulating important plant processes
Similar to insulin in humans, plants also produce peptide hormones that orchestrate internal processes and responses, including growth, development, and immunity. One of them is RALF23, which belongs to the large family of RALF plant peptides. Notably, the study revealed a novel recognition mechanism for the RALF23 peptide signals by plant receptors.

Health - Pharmacology - 08.07.2019
Best treatment for herniated disc
A herniated disc is painful - and the most frequent cause of spinal surgery. But is the selected treatment always the right one? New research results show that the clinical criteria - the comparison of two static images - are often not sufficient to make the best decision for the patient. Sudden back pain is often caused by a herniated disc.

Health - Pharmacology - 28.06.2019
Medicines made of solid gold to help the immune system
Medicines made of solid gold to help the immune system
By studying the effects of gold nanoparticles on the immune cells related to antibody production,  researchers at UNIGE, at Swansea University and at the NCCR "Bio-inspired Materials" are paving the way for more effective vaccines and therapies. Over the past twenty years, the use of nanoparticles in medicine has steadily increased.

Health - Pharmacology - 27.06.2019
Interventions for Schistosomiasis Elimination in Zanzibar
Interventions for Schistosomiasis Elimination in Zanzibar
Schistosomiasis is a neglected tropical disease with a huge impact on global health. More than 200 million people are infected, mainly in sub-Saharan Africa. Researchers from Swiss TPH, the Natural History Museum London and partner institutions in Zanzibar have published a study on interventions for schistosomiasis elimination in Zanzibar, which found that while schistosomiasis was eliminated as a public health problem in over 90% of the study regions, transmission is not yet interrupted and reinfection occurs.

Health - Pharmacology - 27.06.2019
Hydrogel developed at EPFL offers real promise in treating diabetes
Hydrogel developed at EPFL offers real promise in treating diabetes
Researchers at EPFL have developed a hydrogel that offers unrivaled protection against transplanted cell rejection. The School's Technology Transfer Office has licensed the new product to Cell-Caps, a Geneva-based startup specialized in cell encapsulation for treating diabetes. Transplanted tissue often comes under attack from the body's immune system and struggles to survive in the hostile host environment.

Pharmacology - Life Sciences - 24.06.2019
New Therapy Promotes Vascular Repair Following Stroke
New Therapy Promotes Vascular Repair Following Stroke
Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions. This also promotes the regaining of motor functions, researchers at the University of Zurich have shown in a mouse model. The study opens up new avenues for treatment.

Pharmacology - Life Sciences - 17.06.2019
Preventing drugs from being transported
Certain membrane proteins specialise in transporting molecules out of cells - a problem for the efficacy of cancer medication and antibiotics. An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment. The transport proteins, called ABC exporters, are present, for instance, in the cell membranes of bacteria and in large quantities in cancer cells and are responsible for transporting small molecules out of the cells.

Pharmacology - Health - 14.06.2019
Compound with anti-aging effects passes human trial
Compound with anti-aging effects passes human trial
Urolithin A, a metabolite of biomolecules found in pomegranates and other fruits, could help slow certain aging processes. EPFL spin-off Amazentis, in conjunction with EPFL and the Swiss Institute of Bioinformatics, has published a paper Metabolism outlining the results of their clinical trial. It is a fact of life that skeletal muscles begin to lose strength and mass once a person reaches the age of 50.

Pharmacology - Chemistry - 11.06.2019
Learning from Nature's Bounty: New Libraries for Drug discovery
Learning from Nature’s Bounty: New Libraries for Drug discovery
Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult to emulate and build on Nature's success in the laboratory.

Pharmacology - Health - 21.05.2019
Using 3D to test personalised treatments in five days
Using 3D to test personalised treatments in five days
UNIGE researchers have developed a cell co-culture platform that can reproduce a patient's tumour in 3D and test the best treatment combinations for its specific case in just five days. Why doesn't the same treatment work in the same way for every patient? How can a drug's performance be optimised without causing side effects due to an excessive dosage? In an attempt to answer these questions, researchers at the University of Geneva (UNIGE), Switzerland, have devised a cell co-culture platform that reproduces a patient's tumour structure in 3D.

Health - Pharmacology - 26.04.2019
Individual nutrition shows benefits in hospital patients
Individual nutrition shows benefits in hospital patients
Individualized nutrition not only causes hospital patients to consume more protein and calories, but also improves clinical treatment outcomes. This has been demonstrated in a study by researchers from the University of Basel and Aarau Cantonal Hospital in the journal The Lancet. People who struggle to eat and drink properly following an illness are at risk of consuming too little protein and energy.
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