A) Representative model showing the spreading of melanoma cells from the skin to the sentinel lymph node. B) Microscopy image showing the metastasis of melanoma tumor cells (red color) in a lymph node.
A) Representative model showing the spreading of melanoma cells from the skin to the sentinel lymph node. B) Microscopy image showing the metastasis of melanoma tumor cells ( red color ) in a lymph node. The study "Subcapsular sinus macrophages promote melanoma metastasis to the sentinel lymph nodes via an IL-1?-STAT3 axis" has been published in the scientific journal Cancer Immunology Research. It was led by Dr Santiago González, head of the Infection and Immunity Laboratory at the Institute for Research in Biomedicine (IRB, affiliated with USI) and focused on melanoma metastasis. The study is the result of an international collaboration involving the Molecular Immunology (IRB), Lymphoma Genomics (IOR) laboratories, and researchers from the University of Bern , Ben-Gurion University (Israel) and Universitŕ degli studi dell'Insubria (Italy). Melanoma is the most lethal skin cancer, and its incidence, though low, has steadily increased over the last few years. During melanoma progression, tumor cells spread across the body via the lymphatic system, a network of vessels and organs, called lymph nodes, which are part of the immune system.
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