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Health - Pharmacology - 20.06.2024
Antibiotic resistance: concerning situation in sub-Saharan African children
Antibiotic resistance: concerning situation in sub-Saharan African children
Focusing on enterobacteria, two studies by the University of Geneva and the HUG highlight the alarming situation in this region of the world in terms of antibiotic resistance. Enterobacteriaceae are commensal bacteria of the digestive flora that can be responsible for serious infections. HUG Two meta-analysis undertaken by the Geneva University Hospital (HUG) and the University of Geneva have revealed very worrying numbers of children in Sub-Saharan Africa who are carriers of multi-resistant bacterial strains.

Health - Pharmacology - 03.06.2024
Antibody-peptide inhibitor conjugates: a new path for cancer therapy
Antibody-peptide inhibitor conjugates: a new path for cancer therapy
Cancer treatments often struggle with balancing efficacy and side effects. A new study by scientists offers a promising solution using antibody-peptide inhibitor conjugates to target specific cell types and block the activity of cancer-promoting enzymes called cathepsins. Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions.

Health - Pharmacology - 23.05.2024
New approach to Epstein-Barr virus and resulting diseases
New approach to Epstein-Barr virus and resulting diseases
The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers. Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease, as reported by researchers from the University of Basel and the University Hospital Basel in the journal Science.

Health - Pharmacology - 22.05.2024
Gentler cell therapies for blood cancer
Researchers have developed an approach to -deleting- a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in the journal Nature, the team reports on the promising results obtained in animal experiments and with human cells in the laboratory.

Health - Pharmacology - 16.05.2024
At the right time for tumours
By examining the immune modulations of tumours during the day, scientists from the University of Geneva and the LMU Munich are demonstrating their impact on the diagnosis and management of patients. The currently most promising anti-tumour treatments are immunotherapies, which aim to boost the action of the patients' immune system to fight cancer.

Pharmacology - Chemistry - 24.04.2024
AI designs new drugs based on protein structures
AI designs new drugs based on protein structures
A new computer process developed by chemists at ETH Zurich makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process could revolutionise drug research. "It's a real breakthrough for drug discovery," says Gisbert Schneider, Professor at ETH Zurich's Department of Chemistry and Applied Biosciences.

Pharmacology - Health - 03.04.2024
New Discovery Unravels Malaria Invasion Mechanism
New Discovery Unravels Malaria Invasion Mechanism
A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study, led by the Swiss Tropical and Public Health Institute (Swiss TPH) and Griffith University's Institute for Glycomics, reveals the role of a sugar called sialic acid in this invasion process.

Health - Pharmacology - 21.03.2024
An Immunotherapy to Overcome Resistant Leukemia
An Immunotherapy to Overcome Resistant Leukemia
Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working. Their study also explains why the cancer cells are resistant and how this resistance can be overcome: through concomitant pharmacotherapy or genetically improved CAR T-cells.

Health - Pharmacology - 19.03.2024
Fighting heart attack down to the smallest vessels
Fighting heart attack down to the smallest vessels
Researchers in Bern have co-developed and tested a new method to combat the blockage of tiny coronary arteries after a heart attack. The new approach, born from a cooperation of engineers, clinicians, and industry, offers a treatment option to prevent the death of heart tissue after a heart attack, responsible for poor long-term patient health.

Environment - Pharmacology - 05.03.2024
More targeted treatment of industrial wastewater thanks to aquatic research
More targeted treatment of industrial wastewater thanks to aquatic research
In Switzerland, wastewater treatment has traditionally focused on domestic wastewater - in particular, removal of the nutrients nitrogen and phosphorus. Only more recently has attention also been focused on problematic residues of medicines, pesticides and other chemicals. A new Eawag study, commissioned by the federal authorities, now shows that there is also potential for improvement in the case of emissions from chemical and pharmaceutical plants - both at wastewater treatment plants and within the industrial facilities.

Physics - Pharmacology - 29.02.2024
Cause of clogged hypodermic needles discovered
Cause of clogged hypodermic needles discovered
Researchers at the Paul Scherrer Institute PSI and the ANAXAM technology transfer center have used neutron and synchrotron imaging to determine the conditions under which pre-filled syringes become blocked. In very rare cases, the needles of prefilled syringes may become blocked. This can have potentially detrimental consequences for patients if their medication does not enter the body or the dosage is too low.

Life Sciences - Pharmacology - 02.02.2024
Scientists successfully simulate protein complex that initiates fertilisation
Scientists successfully simulate protein complex that initiates fertilisation
Researchers at ETH Zurich recently developed highly realistic simulations of the proteins on sperm and egg cells coupling together before they fuse. These findings enabled the research team to solve several mysteries of fertilisation at once, which could help to accelerate development of more targeted infertility treatments.

Pharmacology - Health - 24.01.2024
Innovative dengue vaccine successfully tested
Innovative dengue vaccine successfully tested
Unisanté (University of Lausanne) has conducted a clinical study on a new type of vaccine that induces cellular immunity to combat dengue fever. The results have just been published in The Lancet eBioMedicine. They are positive and encourage further investigation. This approach is also promising for other diseases.

Pharmacology - Chemistry - 22.01.2024
New agent blocks stress response
New agent blocks stress response
If the body's natural stress response gets knocked off balance, it can result in physical and mental health disorders. Researchers at ETH Zurich have developed an agent capable of selectively inhibiting this response. Stress isn't merely an oppressive feeling we experience when we're overwhelmed; it's the body's natural reaction to acute or persistent strain.

Pharmacology - Economics - 18.01.2024
A navigation system to combat bottlenecks in medication supply
A navigation system to combat bottlenecks in medication supply
A new model designed by researchers measures how flexible medication distribution systems are in real time. It shows that supply shortages can be eased if pharmaceutical wholesalers coordinate their inventories and reroute scarce products as flexibly as possible along existing supply chains. Supply bottlenecks for medications present major challenges to healthcare systems the world over.

Health - Pharmacology - 18.01.2024
Complement System Causes Cell Damage in Long Covid
Medicine Long Covid patients suffer from chronic symptoms such as fatigue or shortness of breath. As researchers at the University of Zurich and University Hospital Zurich have discovered, this is to some extent due to a part of our immune system called the complement system. The study identified a pattern in the blood proteins that will improve the diagnosis and perhaps also the targeted treatment of Long Covid.

Pharmacology - Health - 09.01.2024
Oral peptides: A new era in drug development
Oral peptides: A new era in drug development
Scientists at EPFL have developed stable orally available cyclic peptides with a much higher bioavailability than current ones, virtually creating a generation of drugs that can target previously untreatable diseases like certain types of cancer. For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

Health - Pharmacology - 08.01.2024
Cultivating lung tumours to personalise treatments
A team from the University of Geneva and HUG has described, for the first time, a precise methodology for developing lung tumor spheroids. A team from the Geneva University Hospitals (HUG) and the University of Geneva has described, for the first time, a precise methodology for developing lung tumor spheroids.

Health - Pharmacology - 04.01.2024
Supercharging CAR-T Cells for Cancer Treatment
Supercharging CAR-T Cells for Cancer Treatment
Transformative research at EPFL introduces CAR-T cells that flourish in tumor environments, paving the way for unparalleled advancements in cancer immunotherapy. At EPFL's School of Engineering, Professor Li Tang's Laboratory of Biomaterials for Immunoengineering has made significant strides in cancer treatment research.

Pharmacology - Health - 18.12.2023
Antibiotic consumption rose massively in the first year of the pandemic
Antibiotic consumption rose massively in the first year of the pandemic
Antibiotics are useless against viruses, including the coronavirus. Nevertheless, doctors in Switzerland prescribed antibacterial drugs about twice as often in the first year of the pandemic as before, report researchers from the University of Basel. A risky practice, warns the research team . It was a time of great uncertainty: when the first coronavirus wave rolled across Switzerland in spring 2020, there were neither diagnostic tests nor a vaccine nor effective medication.
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