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Health - Pharmacology - 05.07.2022
How Omicron dodges the immune system
How Omicron dodges the immune system
By comparing the neutralisation capacity induced by the different variants of SARS-CoV-2, a team from the UNIGE and the HUG reveals the exceptional capacity of Omicron to evade our immunity. The current wave of COVID-19 highlights a particularly high risk of reinfection by the Omicron variant of SARS-CoV-2.

Health - Pharmacology - 27.06.2022
Nitric Oxide Does Not Improve Babies' Recovery after Heart Surgery
Nitric Oxide Does Not Improve Babies’ Recovery after Heart Surgery
Infants undergoing heart surgery are connected to a heart-lung machine and given nitric oxide as an anti-inflammatory. Researchers from the Universities of Zurich and Queensland have now conducted the world's largest study of its kind, showing that using nitric oxide does not improve children's recovery after surgery.

Health - Pharmacology - 16.06.2022
Breakthrough study of hormone 'crosstalk' in breast cancer
Breakthrough study of hormone ’crosstalk’ in breast cancer
Scientists led by EPFL have successfully engrafted breast cancer cells on mice, allowing them to study in vivo the cross-talk between the estrogen and progesterone receptors that hampers hormone therapies. Their findings suggest that endocrine therapy may need to be personalized, and that abrogating progesterone receptor expression can be a therapeutic option.

Pharmacology - Life Sciences - 13.06.2022
An anti-cancer drug acts as an epigenetic memory aid, scientists find
An anti-cancer drug acts as an epigenetic memory aid, scientists find
Scientists have discovered how an anti-cancer drug could be repurposed to improve memory. It does so by supporting the cell's ability to read the very genes that are important for learning. The epigenetic mechanism of the drug is shown in mice. If you are scared of spiders, you may soon benefit from a drug to enhance your ability to unlearn your arachnophobia, without any undesirable side-effects.

Health - Pharmacology - 31.05.2022
A World Premiere: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
A World Premiere: For the First Time, a Human Liver Was Treated in a Machine and Then Successfully Transplanted
The multidisciplinary Zurich research team Liver4Life has succeeded in doing something during a treatment attempt that had never been achieved in the history of medicine until now: it treated an originally damaged human liver in a machine for three days outside of a body and then implanted the recovered organ into a cancer patient.

Health - Pharmacology - 11.05.2022
The combination makes the difference: New therapeutic approach against breast cancer
The combination makes the difference: New therapeutic approach against breast cancer
Some breast tumors with certain genetic alterations are difficult to treat using existing therapies. Researchers at the University of Basel have now discovered an approach that involves a toxic combination with a second target gene in order to kill the abnormal cells. The first clinical trials could be starting soon.

Pharmacology - Health - 09.05.2022
Lymphomas: new model developed at the IOR against drug resistance
Lymphomas: new model developed at the IOR against drug resistance
The Lymphoma Genomics group, directed by Prof. Francesco Bertoni at the Institute of Oncology Research (IOR, affiliated to USI and member of Bios+), identified a new mechanism behind the resistance to the drug idelalisib, used in the treatment of patients with follicular lymphoma and marginal zone lymphoma.

Environment - Pharmacology - 02.05.2022
Bioassays evaluate ozonation and post-treatment of wastewater
Bioassays evaluate ozonation and post-treatment of wastewater
Through wastewater, rivers and lakes are polluted with numerous micropollutants which originate from care products and pharmaceuticals, among other things. The Waters Protection Act therefore aims to expand Swiss wastewater treatment plants (WWTP) with the addition of a further treatment step. In pilot tests, two processes have proven particularly successful in the removal of trace substances: ozonation and treatment with activated carbon.

Health - Pharmacology - 25.04.2022
Retina is not sparged by SARS-CoV-2
Retina is not sparged by SARS-CoV-2
The list of diseases caused by SARS-CoV-2 infection is growing and now includes the retina. This is what suggest a prospective study by the Geneva University Hospitals (HUG) and the University of Geneva. The list of diseases caused by SARS-CoV-2 infection is growing and now includes the retina. This is what suggest a prospective study by the Geneva University Hospitals (HUG) and the University of Geneva , in collaboration with the Adolphe de Rothschild Memorial Clinical Research Center for Ophthalmology.

Health - Pharmacology - 21.04.2022
Targeting ’anti-tumor’ genes to provide better treatment for leukemia
Scientists discuss the possibility of offering personalized treatment for chronic lymphocytic leukemia by regulating the expression of a gene known for its "anti-tumorous" properties. Chronic lymphocytic leukemia (CLL) is one of the most common blood cancers in adults. The disease originates in B cells - the part of the immune system that produces antibodies - and then evolves slowly, typically affecting older people.

Health - Pharmacology - 12.04.2022
COVID-19: Vaccination greatly reduces infectious viral load
By comparing the infectious viral load caused by ancestral SARS-CoV-2 as well as by the Delta and Omicron variants, scientists from the University of Geneva and HUG highlight the benefits of vaccination. To conduct the research, the UNIGE and HUG team was able to reanalyze samples from previous waves of the disease.

Pharmacology - Health - 29.03.2022
An approach to treating a severe congenital myopathy
An approach to treating a severe congenital myopathy
The diagnosis is rare, but devastating - children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital Basel are now presenting a possible therapeutic approach for the first time. Professor Susan Treves remembers seeing one child affected by the condition at the age of six months.

Health - Pharmacology - 08.03.2022
Origins of metastasis
Origins of metastasis
Researchers at the University of Geneva show that the experience of impending cell death within a primary  tumour can lead to the development of «pro-metastatic» cells. Metastatic cells form in a primary tumour and then break away from it, migrate to other organs, attach to them and form new tumours.

Health - Pharmacology - 25.02.2022
Gut Microbiota Influences Treatment against Parasitic Worms
Gut Microbiota Influences Treatment against Parasitic Worms
Almost a quarter of the world's population is at risk of helminth infections and available treatment options are limited. Therefore, a better understanding of why anti-parasitic drugs fail in certain cases is crucial. A new study by Swiss TPH sheds light on how gut bacteria affect treatment outcomes against parasitic worms.

Pharmacology - Health - 17.02.2022
Defeating leukaemia cells by depriving them of energy
Defeating leukaemia cells by depriving them of energy
A Swiss-French team that includes scientists has discovered how to trigger apoptosis in leukaemia cells by disrupting their energy maintenance mechanism. Acute myeloid leukaemia, which affects blood and bone marrow cells, is a particularly dangerous form of cancer. More than half of patients under the age of 60 die.

Life Sciences - Pharmacology - 10.02.2022
Illuminating Real-Time Brain Dynamics of Neuropeptides with a Fluorescent Biosensor
Illuminating Real-Time Brain Dynamics of Neuropeptides with a Fluorescent Biosensor
Neuropeptides play fundamental roles in modulating cellular and circuit functions within the brain. One such signaling molecule - orexin - regulates arousal and wakefulness, and its failure can lead to constant daytime sleepiness (narcolepsy). University of Zurich researchers have now developed a fluorescent orexin biosensor to observe this molecule "live" in the living mouse brain.

Health - Pharmacology - 02.02.2022
Immunological Memory Provides Long-Term Protection against Coronavirus
Immunological Memory Provides Long-Term Protection against Coronavirus
Exposure to SARS-CoV-2 by infection or vaccination generates immune cells that provide long-term immunity. These long-lived memory T cells play a key role in preventing severe cases of Covid-19. Researchers at the University of Zurich have now discovered how these memory T cells form. Many questions about how exposure to SARS-CoV-2 by infection or immunization might result in long-term protective immunity remain unanswered.

Life Sciences - Pharmacology - 01.02.2022
Localis-rex: a new tool for studying electrophile signaling
A team of researchers led by Professor Yimon Aye at EPFL's School of Basic Sciences has developed a new screening method to explore an important biological process known as electrophile signaling. In general, an electrophile is a highly reactive compound that -seeks- to bond with atoms or other molecules that have an available electron pair.

Health - Pharmacology - 27.01.2022
Omicron unlikely to push health system to limits
Omicron unlikely to push health system to limits
Seemingly less hazardous than Delta, but significantly more infectious: The spread of the omicron variant of the SARS-CoV-2 coronavirus raises the question of whether it can push the healthcare system to its breaking point. researchers have worked with partners to model scenarios for both Switzerland and Germany - and conclude that this is an unlikely course of events.

Health - Pharmacology - 13.01.2022
'It may be possible to prevent MS by means of vaccination.'
’It may be possible to prevent MS by means of vaccination.’
A large-scale study in the scientific journal Science reveals that the Epstein-Barr virus responsible for causing glandular fever is involved in the development of multiple sclerosis. Professor Jens Kuhle, who participated in the project, summarizes the results in an interview. Professor Kuhle, almost everyone is infected with the Epstein-Barr virus (EBV), usually without symptoms.
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