Illustration of the mTORC2 architecture: The mTOR protein is highlighted in red. mTORC2 specific accessory proteins are colored cyan. (Image: Christopher H.S. Aylett)
The protein complex mTORC2 controls cellular lipid and carbohydrate metabolism. Researchers from the Biozentrum of the University of Basel and the ETH Zurich have now succeeded in deciphering the 3D structure of this important protein complex. The results have recently been published in "eLife". The protein complex mTORC2 plays a crucial role in the regulation of cellular metabolism. It stimulates, for example, the production of lipids and fatty acids, but it also controls carbohydrate metabolism. In the past, studies have shown that mTORC2 promotes tumor growth due to increased lipid production and that it is involved in the development of diabetes. The term mTORC2 derives from the fact that two such complexes exist in the cell.
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