Schematic illustration of the bio-catalytic nanocompartment with encapsulated enzyme phosphoglucomutase for the conversion of glucose-1-phosphate (blue circles) into the desired product glucose-6-phosphate (orange circles).
Researchers at the University of Basel succeeded in developing capsules capable of producing the bio-molecule glucose-6-phosphate that plays an important role in metabolic processes. The researchers were able to produce the metabolite in conditions very similar to the biochemical reaction inside natural cells. Metabolic processes inside living organisms involve a large variety of bio-molecules. These molecules are produced by specific enzymatic reactions. One example of such a bio-molecule is glucose-6-phosphate, a metabolite that is involved in important metabolic processes. It is central in the degradation of carbohydrates and can also be converted further into specific molecules responsible for storing energy within an organism. If such bio-molecules can be produced directly inside living cells, new perspectives in the treatment of disease would open up.
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