A global group of researchers is calling for better integration of viral genetics, bioinformatics, and public health to enable better pandemic response now and better pandemic preparedness in the future. In a comment piece , an international collaboration of specialists in viral and genetic analysis lay out the 'bioinformatics bottlenecks' that are hindering response to the SARS-CoV-2 pandemic, and propose ways to 'clear the road' for better tools and approaches.

Cancer research has discovered a further mechanism to combat leukemia: a research team has succeeded in identifying an important signaling pathway for regulating leukemic stem cells. With this discovery, the researchers are expanding the arsenal of potentially highly effective drugs against leukemias ("blood cancers").

In the canton of Bern, Switzerland, only 14% of the adult population were infected with the coronavirus and developed antibodies against SARS-Cov-2. These are the preliminary results of a seroprevalence study coordinated by the Swiss School of Public Health and carried out in Bern by the University of Bern in cooperation with the Inselspital, University Hospital of Bern.

Unlike their simple counterparts in artificial intelligence (AI) applications, neurons in the brain use dendrites - their intricate tree-like branches - to find relevant chunks of information. Now, neuroscientists from the University of Bern have discovered a new computational method to make complex dendrite models much simpler. These faithful reductions may lead AI applications to process information much like the brain does.

How dangerous are new mutations of the SARS-CoV-2 virus? An international team involving researchers from the Institute of Virology and Immunology (IVI) of the Federal Food Safety and Veterinary Office BLV and the University of Bern (Switzerland), the Centers for Disease Control and Prevention (USA), and the Friedrich-Loeffler Institute (Germany), has developed an approach that can accurately assess the transmissibility of new virus mutants.

In collaboration with clinical partners from the Inselspital, researchers from the ARTORG Center for Biomedical Research of the University of Bern have developed a second-generation lung-on-chip model with life-size dimension alveoli in a stretchable membrane, made of purely biological material. The new model reproduces key aspects of the lung tissue architecture not found in previous lungs-on-chip. This opens up new possibilities for basic pneumological research, understanding lung pathologies, drug screening and precision medicine.

This year, four of a total of fifteen Pfizer Research Prizes have been awarded to physicians from the University of Bern and the Inselspital, University Hospital Bern. The award-winning work deals with leukemia, cardiac arrhythmias and the fever threshold in children and adolescents with cancer.

The University of Bern is establishing a multidisciplinary center to study the origin and course of infectious diseases and their impact on health, society and economics. The new research center is to receive some 30 million Swiss Francs financial support from the Vinetum Foundation over a period of 10 years.