wire - news in brief

This research explores a new opensource method for high dimensional spatial proteomic imaging of complex tissue samples, revealing disparate spatial reorganization in glioblastoma and brain metastasis following radiotherapy.

A study by BEAM researchers, published in "Science of Learning", offers new insights into brain mechanisms linked to differences in associative learning. This research explores how attentional processes influence learning performance, shedding light on our understanding of how the brain works to create relationships between information .

New article on jigsaw learning published in Sage Journals The jigsaw classroom is a cooperative learning method designed in the late 1970s to improve the academic performance of minority children by reducing intergroup conflict and increasing self-evaluations.

The inflammasome plays a pivotal role in our immune system, essentially serving as an intricate alarm mechanism within our cells that combats infections and diseases.

New article on immigrant political participation in Europe and Swiss cantons published online Comparative Migration Studies Immigrants are increasingly participating in politics, publicizing their political concerns and contributions.

This new research discovered that patients with metastatic melanoma who respond to adoptive T cell therapy exhibit a coordinated crosstalk between intratumoral myeloid cells and tumor-reactive CD8+ T cells. The study *, published in Science Immunology , was conducted by Dr David Barras, Dr Eleonora Ghisoni, Dr Johanna Chiffelle and colleagues and directed by Dr Denarda Dangaj and Pr George Coukos , members of the Lausanne Branch of the Ludwig Institute for Cancer Research.

Researchers from the Department of Oncology UNIL-CHUV published a new study in Immunity, showing that machine learning improves the prioritization of cancer specific mutations for cancer immunotherapy. The study *, published in Immunity , was conducted by Markus Müller, a senior scientist in the Immunopeptidomics group headed by Michal Bassani-Sternberg, within the Human Integrated Tumor Immunology Discovery Engine (Hi-TIDe), part of the Ludwig Lausanne branch, which is directed by Pr George Coukos.

For the first time, researchers at CHUV's Department of Gastroenterology and Hepatology and EPFL have shed light on the role of host genetics in the response to hepatitis E virus infection.

Swelling of one or more limbs due to lymphedema affects one in five women undergoing breast cancer surgery following the operation.

Researchers from the UNIL-CHUV Department of Oncology and the Lausanne branch of the Ludwig Institute publish a new study in "Immunity", demonstrating that machine learning improves the prioritization of specific mutations in certain cancer candidates for immunotherapy treatment. Some forms of cancer contain numerous mutations, but only a restricted sub-population, usually a few dozen, can be incorporated into the immunotherapy strategy.

Playing Tetris for fifteen minutes can prevent psychological trauma in mothers after a difficult birth: so suggests a large-scale study conducted at CHUV and HUG and published in Molecular Psychiatry.

Researchers at the Department of Oncology (UNIL-CHUV) have published an in-depth analysis in the prestigious journal "Cell", shedding light on the hitherto unknown functions of neutrophils in brain tumor environments. Brain tumors remain one of the most complex medical challenges of our time, affecting thousands of lives every year.

In line with federal figures, animal experimentation at UNIL-CHUV has risen by 4% in 2022. This slight increase is due to the increased use of zebrafish, the boom in cancer research and, above all, the post-Covid catch-up.

New study in Science Immunology shows that individuals with Parkinson's disease exhibit decreased levels of CD8+ memory T cells and fail to generate memory T cells in response to COVID-19 vaccination.

Scientists at CHUV and the University of Lausanne have shown that in people living with HIV and taking antiretroviral treatment, cells functioning as "reservoirs" continue to produce parts of the virus that continually stimulate the immune system. This discovery opens the way to new therapeutic approaches.

An analysis conducted by Cleo Bertelsmeier and Aymeric Bonnamour at the University of Lausanne's Department of Ecology and Evolution and published in "PNAS" reveals that the spread of plants precedes and favors the establishment of insects outside their region of origin. Based on the time lag observed, the scientists estimate that in the near future, discoveries of non-native insects could increase by 35% worldwide .

Inclusive social norms and nationals' positive intergroup orientations toward refugees: The moderating role of initial prejudice and intergroup contact Research on the interplay between inclusive norms and intergroup contact on improving intergroup orientations has yielded conflicting results, suggesting either that an experience of personal contact is necessary to have a positive effect of inclusive norms or that such personal experience is not always necessary.

Novel chimeric antigen receptors (CARs) with different configurations of the natural ligand APRIL for BCMA and TACI antigens delivered fast anti-tumor responses but did not protect from tumor recurrence, similar to CAR T cell therapies using antibody fragments for BCMA binding. The Arber Lab identifies potential mechanisms of resistance shared by different CAR T cell types targeting BCMA.

Assessing the impact of Quaternary glaciation at the Earth's surface implies understanding of the long-term evolution of alpine landscapes.

A new treatment modality for colorectal cancers that do not respond to standard chemotherapy has been identified by Tatiana Petrova of the Lausanne Branch of the Ludwig Institute for Cancer Research and Michele De Palma of the EPFL. Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality.

Rebekka Schairer from Prof. Thome's lab just published an article in PNAS, which provides new molecular insights into the mechanisms of lymphocyte activation and lymphoma development.

The Universities of Lausanne, Fribourg and Zurich launch in September 2019 a new 'Sinergia' research consortium entitled 'Local power structures and transnational connections.

A new method shows that the relationships between living species, from bacteria to plants and animals, are different from previous estimates.

Johanna Joyce, Ludwig member, co-signs a position paper on the challenges the scientific community faces in the fight against primary brain tumours On the initiative of Cancer Research UK, an international panel of brain cancer researchers and clinicians assessed the most important challenges ahead in the development of effective treatmens for patients.

Although it is widely accepted that governance rules play a major role in the smooth running of businesses and contribute to market equilibrium, how can we measure businesses' degree of responsibility in this area?