News in Brief
Life Sciences - Oct 15
New system developed for rapid SARS-CoV-2 variant characterization and facilitated drug development
New system developed for rapid SARS-CoV-2 variant characterization and facilitated drug development
Health - Oct 15
Roche announces PathAI collaboration for artificial intelligence-based digital pathology applications for improved patient care
Roche announces PathAI collaboration for artificial intelligence-based digital pathology applications for improved patient care
Pharmacology - Oct 15
US FDA approves Roche's Tecentriq as adjuvant treatment for certain people with early non-small cell lung cancer
US FDA approves Roche's Tecentriq as adjuvant treatment for certain people with early non-small cell lung cancer
Pharmacology - Oct 14
Roche's Gazyvaro shorter 90-minute infusion time approved in Europe for people with previously treated or untreated follicular lymphoma
Roche's Gazyvaro shorter 90-minute infusion time approved in Europe for people with previously treated or untreated follicular lymphoma
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Results 21 - 40 of 279.
Researchers in the Friedrich group have contributed to create an atlas that links subcellular structures to gene expression in each cell of the sea worm Platynereis dumerilii , a key model organism for the study of development and evolution. The atlas will help researchers to shed light onto molecular and cellular mechanisms at play in our very ancient ancestors.
It is still elusive to what extent interactions between different cell types of the heart influence the normal heart rhythm and possibly trigger life-threatening arrhythmias. A new measurement method developed at the University of Bern combines for the first time optical and electrical recording of cardiac ventricular activation which, in conjunction with optogenetics, will permit finding comprehensive answers to these questions.
Scientists at EPFL and Dartmouth College in the US have developed a system that can, for the first time, both pinpoint the exact location of a tumor and measure its depth. Their technology employs a high-tech camera developed at EPFL's Advanced Quantum Architecture Laboratory. A few years ago, Edoardo Charbon, an EPFL professor and head of the Advanced Quantum Architecture Laboratory, unveiled a new, ultra-high-power camera called SwissSPAD2.
Evolution plays a crucial role in ecosystem tipping points, as shown in two recently published studies by researchers. If this influence is taken into account, ecosystem collapses can be better predicted in the future. At the same time, the studies reveal how the risk of ecosystem collapse can be reduced and the chances of recovery increased.
In the largest worldwide pricing experiment to date, researchers have demonstrated that road users change their behavior when they must pay for the social and environmental effects of their transportation. The study was led by researchers from the University of Basel, ETH Zurich and ZHAW. Transportation causes a variety of costs that individual road users do not have to pay themselves.
Scientists at EPFL have shown that the powerful transient absorption spectroscopy technique can unravel ultrafast motion of electrons and nuclei in a molecule in real time and with atomic spatial resolution. The last few decades have seen impressive progress in laser-based technologies, which have led to significant advancements in atomic and molecular physics.
A team from the University of Geneva has identified a gene that is essential for regulating the sleep-wake cycles of Drosophila. All living organisms are subject to an internal biological rhythm, which controls many physiological processes. In humans in particular, this internal clock follows a 24-hour cycle and occurs even in the absence of external triggers, such as changes in light or temperature.
Under an initiative by EPFL's Center for Imaging, a team of engineers from EPFL and Universidad Carlos III de Madrid have developed a plugin that makes it easier to incorporate artificial intelligence into image analysis for life-science research. The plugin, called deepImageJ, is described in a paper appearing today.
A tool to interrogate a new class of drugs
Reactive electrophilic drugs like Tecfidera, approved for the treatment of relapsing multiple sclerosis, show a lot of potential but are also mystery. Their effects are notoriously difficult to study, which hampers progress testing and approving them. scientists have now used an innovative chemical method to uncover the biological mechanisms of Tecfidera, providing a powerful tool for exploring other reactive electrophilic drugs.
Reactive electrophilic drugs like Tecfidera, approved for the treatment of relapsing multiple sclerosis, show a lot of potential but are also mystery. Their effects are notoriously difficult to study, which hampers progress testing and approving them. scientists have now used an innovative chemical method to uncover the biological mechanisms of Tecfidera, providing a powerful tool for exploring other reactive electrophilic drugs.
Researchers at the University of Geneva and the Clinique romande de réadaptation in Sion have mapped the biomarkers of different types of pain to categorise and better treat them in the future. Many people are confronted with chronic pain that can last for months or even years. How to best treat chronic pain? First, pain must be categorized for the right treatment to be prescribed.
Successfully introducing innovations
Although the consequences of climate change are becoming more and more visible and tangible, the transition to climate-friendly energy systems is only proceeding slowly. In a field experiment, Eawag and the University of Groningen (NL) investigated what kind of measures could be used to better promote innovations such as heat pumps.
Although the consequences of climate change are becoming more and more visible and tangible, the transition to climate-friendly energy systems is only proceeding slowly. In a field experiment, Eawag and the University of Groningen (NL) investigated what kind of measures could be used to better promote innovations such as heat pumps.
Commercially viable production of climate-neutral plastic is possible
By cleverly combining different technologies, manufacturers can produce plastic that is climate neutral over its entire life cycle. A new study by an international team of researchers has shown that this combination requires less energy than alternatives and costs the same - or even less. Since the early 1950s, plastics have found their way into almost every area of modern life.
By cleverly combining different technologies, manufacturers can produce plastic that is climate neutral over its entire life cycle. A new study by an international team of researchers has shown that this combination requires less energy than alternatives and costs the same - or even less. Since the early 1950s, plastics have found their way into almost every area of modern life.
A revolutionary implant developed at EPFL allows neuroscientists to activate or inhibit specific spinal-cord neurons by applying light at a specific wavelength. It will give researchers insight into how the nervous system works and the chance to develop new ways of treating neurological disorders. Grégoire Courtine doesn't hesitate to use the word "revolutionary" when describing the emerging field of optogenetics - a technology that uses pulses of light to control individual neural activity - and what it could mean for neuroscience.
Teams from the UNIGE and EPFL have used for the first time the method of longitudinal network analysis applied to children, in order to detect the symptoms that herald the development of psychotic illness in the future. One third of children with a microdeletion of chromosome 22 will later develop a psychotic illness such as schizophrenia.
Robust gene networks from the depths of our evolutionary history
A sophisticated system guides the development of our limbs. Researchers at University of Basel have shed new light on the genetic toolkit used during evolution to create a range of different extremities such as fins, wings, hooves, toes and fingers. Much can go wrong when a fertilized egg develops into an embryo and ultimately gives rise to a newborn as mutations in the genome that affect development are relatively common.
A sophisticated system guides the development of our limbs. Researchers at University of Basel have shed new light on the genetic toolkit used during evolution to create a range of different extremities such as fins, wings, hooves, toes and fingers. Much can go wrong when a fertilized egg develops into an embryo and ultimately gives rise to a newborn as mutations in the genome that affect development are relatively common.
Mercury released into the atmosphere by industry enters the sea and from there makes its way into the food chain. Now, an analysis by the University of Basel has revealed how the harmful substance enters seawater in the first place. This is not primarily via rainfall, as previously assumed, but rather also involves gas exchange.
Antidepressants Inhibit Cancer Growth in Mice
Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term. In some cases the tumors disappeared completely, researchers at UZH and USZ have found.
Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term. In some cases the tumors disappeared completely, researchers at UZH and USZ have found.
A new assay developed by EPFL spin-off Nanolive opens up promising avenues of research for immuno-oncology treatments. It allows scientists to directly see and quantify how T cells find, bind, stress and kill cancer cells. Immuno-oncology is a promising new field of research that involves boosting the capacity of a patient's own immune system to attack cancer cells.
Decrease in mortality from rare side effect
A large-scale international study co-led by Inselspital and the University of Bern investigated the very rare adverse cerebral venous occlusion (sinus venous thrombosis) after administration of the Oxford-AstraZeneca and Janssen/Johnson&Johnson vaccines. Neither vaccine has been used in Switzerland to date.
A large-scale international study co-led by Inselspital and the University of Bern investigated the very rare adverse cerebral venous occlusion (sinus venous thrombosis) after administration of the Oxford-AstraZeneca and Janssen/Johnson&Johnson vaccines. Neither vaccine has been used in Switzerland to date.
Researchers at the Paul Scherrer Institute PSI are the first to have joined two proteins together by means of a free-standing, rigid link. The structural element holds the two protein molecules together at a defined distance and angle, much the way a barbell handle connects two weights. This type of linkage could help, for example, to develop so-called virus-like particles for vaccines.
News in Brief
Life Sciences - Oct 15
New system developed for rapid SARS-CoV-2 variant characterization and facilitated drug development
New system developed for rapid SARS-CoV-2 variant characterization and facilitated drug development
Health - Oct 15
Roche announces PathAI collaboration for artificial intelligence-based digital pathology applications for improved patient care
Roche announces PathAI collaboration for artificial intelligence-based digital pathology applications for improved patient care
Pharmacology - Oct 15
US FDA approves Roche's Tecentriq as adjuvant treatment for certain people with early non-small cell lung cancer
US FDA approves Roche's Tecentriq as adjuvant treatment for certain people with early non-small cell lung cancer
Pharmacology - Oct 14
Roche's Gazyvaro shorter 90-minute infusion time approved in Europe for people with previously treated or untreated follicular lymphoma
Roche's Gazyvaro shorter 90-minute infusion time approved in Europe for people with previously treated or untreated follicular lymphoma